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The protein encoded by RNF135 contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Additionally we are shipping Ring Finger Protein 135 Antibodies (44) and Ring Finger Protein 135 Proteins (6) and many more products for this protein.
Data showed that the presence of the RNF135 K115 variant in the genotype of patients with autism was statistically significant.
Riplet-mediated K63-linked polyubiquitination released RIG-I (show DDX58 ELISA Kits) RD autorepression, which allowed the access of positive factors to the RIG-I (show DDX58 ELISA Kits) protein.
REUL is an E3 ubiquitin ligase of RIG-I (show DDX58 ELISA Kits) and specifically stimulates RIG-I (show DDX58 ELISA Kits)-mediated innate antiviral activity
These data identify RNF135 as causative of a new overgrowth syndrome and demonstrate that RNF135 haploinsufficiency contributes to the phenotype of NF1 (show NF1 ELISA Kits) microdeletion cases.
identify an alternative factor, Riplet/RNF135, that promotes RIG-I (show DDX58 ELISA Kits) activation independent of TRIM25 (show TRIM25 ELISA Kits)
RNF135 mutations are not present in patients with Sotos (show NSD1 ELISA Kits) syndrome-like features.
Riplet is essential for regulating RIG-I (show DDX58 ELISA Kits)-mediated innate immune response against RNA virus infection in vivo.
The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
E3 ubiquitin-protein ligase RNF135
, RIG-I E3 ubiquitin ligase
, U 2-3-0