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The protein encoded by RNF139 is a multi-membrane spanning protein containing a RING-H2 finger. Additionally we are shipping Ring Finger Protein 139 Antibodies (57) and Ring Finger Protein 139 Proteins (4) and many more products for this protein.
interaction with Bag1 (show BAG1 ELISA Kits) then shifts hERG (show KCNH2 ELISA Kits) degradation to the membrane-anchored E3 ligase TRC8 and its E2-conjugating enzyme Ube2g2 (show UBE2G2 ELISA Kits), as determined by siRNA screening
TRC8 and TMEM129 are endoplasmic reticulum-associated degradation ubiquitin E3 ligases for viral and cellular targeting of MHC class I. (Review)
TRC8 suppresses tumorigenesis through targeting heme oxygenase-1 (show HMOX1 ELISA Kits) for ubiquitination and degradation.
TRC8 function may provide a regulatory link between the lipid and protein biosynthetic pathways.
TRC8 modulation of sterol response element binding protein activity comprises a novel regulatory link between growth control and the cholesterol/lipid homeostasis pathway.
The presence of diploid and tetraploid tumor cells with and without TRC8 deletions on the nontranslocated chromosome suggest that loss of the remaining normal allele of TRC8 may contribute to tumor development at later stages.
TRC8 is a novel sterol-sensing endoplasmic reticulum membrane protein that hinders SREBP-2 processing through interaction with SREBP-2 and SCAP, regulating its own turnover rate by means of its E3 ubiquitin ligase activity
Data show that the TRC8 E3 ligase is required for MHC I dislocation from the ER and identify a new complex associated with mammalian ERAD.
The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.
E3 ubiquitin-protein ligase RNF139
, multiple membrane spanning receptor TRC8
, patched related protein translocated in renal cancer
, translocation in renal carcinoma on chromosome 8 protein
, RING finger protein 139
, ring finger protein 139 S homeolog