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E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Additionally we are shipping Ring Finger Protein 144B Proteins (4) and many more products for this protein.
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Human Monoclonal RNF144B Primary Antibody for IF, WB - ABIN396360
Rose, Behm, Drgon, Johnson, Uhl: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. in Molecular medicine (Cambridge, Mass.) 2010
Show all 5 references for ABIN396360
findings substantiate PIR2/Rnf144b as a potentially critical component of epithelial homeostasis, acting downstream of DeltaNp63alpha to regulate cellular levels of p21(WAF1/CIP1 (show CDKN1A Antibodies)) and DeltaNp63alpha
PIR2/RNF144B/IBRDC2 regulates the stability of TAp73 and DNp73.
IBRDC2, an IBR-type RING-finger (show PCGF1 Antibodies) E3 ubiquitin ligase (show MUL1 Antibodies), regulates the levels of Bax (show BAX Antibodies) and protects cells from unprompted Bax (show BAX Antibodies). activation and cell death.
p53RFP, a p53-inducible RING-finger protein, regulates the stability of p21WAF1.
PIR2, by being induced by TAp73 and degrading DeltaNp73, differentially regulates TAp73/DeltaNp73 stability.[PIR2]
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death\; But, it is not an anti-apoptotic protein per se (By similarity).
E3 ubiquitin-protein ligase RNF144B
, IBR domain containing 2
, IBR domain-containing protein 2
, p53-inducible RING finger protein
, ring finger 144B