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Ring Finger Protein 168 (RNF168) ELISA Kits

RNF168 encodes an E3 ubiquitin ligase protein that contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. Additionally we are shipping RNF168 Antibodies (57) and RNF168 Proteins (6) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse RNF168 RNF168 70238 Q80XJ2
Anti-Human RNF168 RNF168 165918 Q8IYW5
Anti-Rat RNF168 RNF168 690043 B2RYR0
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More ELISA Kits for RNF168 Interaction Partners

Mouse (Murine) Ring Finger Protein 168 (RNF168) interaction partners

  1. RNF168, in complex with RAD6A (show ube2a ELISA Kits) or RAD6B (show UBE2B ELISA Kits), is activated in the DNA-damage-induced protein ubiquitination cascade.

  2. Rnf168 is important for maintaining genomic integrity, and it cooperates with p53 (show TP53 ELISA Kits) in suppressing tumorigenesis.

Human Ring Finger Protein 168 (RNF168) interaction partners

  1. The association of RNF168 with PML NBs resulted in increased ubiquitylation.

  2. Results reveal an important role of USP7 (show USP7 ELISA Kits) in regulating ubiquitin-dependent signaling via stabilization of RNF168.

  3. CK2 (show CSNK2A1 ELISA Kits)/WIP1 (show PPM1D ELISA Kits)-mediated modulation of LSD1 (show KDM1A ELISA Kits) phosphorylation facilitates RNF168-dependent ubiquitination and recruitment of 53BP1 (show TP53BP1 ELISA Kits) to the DNA damage sites.

  4. The ubiquitin ligase RNF168 is strictly dependent on the activity that UbK27 is required to promote chromatin ubiquitination following DNA damage.

  5. Finding that RNF8 (show RNF8 ELISA Kits) is less abundant than RNF168 identifies RNF8 (show RNF8 ELISA Kits) as a rate-limiting determinant of focal repair complex assembly

  6. Depletion of RNF8 (show RNF8 ELISA Kits) or RNF168 blocks the degradation of diffusely localized nuclear 53BP1 (show TP53BP1 ELISA Kits).

  7. The E3 ligase RNF168 promotes both H2A ubiquitylation and neddylation. RNF168 is itself a substrate for NEDD8, and neddylation of RNF168 is necessary for its E3 ubiquitin activity.

  8. The acidic patch functions within the nucleosome as nucleosomes containing a mutated acidic patch exhibit defective H2A/H2AXub by RNF168 and RING1B (show RNF2 ELISA Kits)/BMI1 (show BMI1 ELISA Kits) in vitro

  9. Taken together, the results suggested that USP3 is a negative regulator of ubiquitination signaling, counteracting RNF168- and RNF8 (show RNF8 ELISA Kits)-mediated ubiquitination

  10. Before their localization to DNA double strand breaks, RNF168 interacts with 53BP1 and modifies it through the addition of a chain of ubiquitin-polypeptides.

RNF168 Antigen Profile

Antigen Summary

This gene encodes an E3 ubiquitin ligase protein that contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The protein is involved in DNA double-strand break (DSB) repair. Mutations in this gene result in Riddle syndrome.

Gene names and symbols associated with RNF168

  • ring finger protein 168 (Rnf168) antibody
  • ring finger protein 168, E3 ubiquitin protein ligase (rnf168) antibody
  • ring finger protein 168, E3 ubiquitin protein ligase (RNF168) antibody
  • ring finger protein 168, E3 ubiquitin protein ligase (Rnf168) antibody
  • 3110001H15Rik antibody
  • hRNF168 antibody

Protein level used designations for RNF168

E3 ubiquitin-protein ligase RNF168 , ring fnger protein 168

GENE ID SPECIES
70238 Mus musculus
432198 Xenopus laevis
770166 Gallus gallus
165918 Homo sapiens
488029 Canis lupus familiaris
613812 Bos taurus
690043 Rattus norvegicus
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