You are viewing an incomplete version of our website. Please click to reload the website as full version.

Ring Finger Protein 168 Proteins (RNF168)

RNF168 encodes an E3 ubiquitin ligase protein that contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. Additionally we are shipping RNF168 Antibodies (57) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RNF168 70238 Q80XJ2
RNF168 165918 Q8IYW5
RNF168 690043 B2RYR0
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top RNF168 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,617.17
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

RNF168 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,
Rat (Rattus)

More Proteins for Ring Finger Protein 168 (RNF168) Interaction Partners

Mouse (Murine) Ring Finger Protein 168 (RNF168) interaction partners

  1. RNF168, in complex with RAD6A (show ube2a Proteins) or RAD6B (show UBE2B Proteins), is activated in the DNA-damage-induced protein ubiquitination cascade.

  2. Rnf168 is important for maintaining genomic integrity, and it cooperates with p53 (show TP53 Proteins) in suppressing tumorigenesis.

Human Ring Finger Protein 168 (RNF168) interaction partners

  1. The association of RNF168 with PML (show PML Proteins) NBs (show NBN Proteins) resulted in increased ubiquitylation.

  2. Results reveal an important role of USP7 (show USP7 Proteins) in regulating ubiquitin-dependent signaling via stabilization of RNF168.

  3. CK2 (show CSNK2A1 Proteins)/WIP1 (show PPM1D Proteins)-mediated modulation of LSD1 (show KDM1A Proteins) phosphorylation facilitates RNF168-dependent ubiquitination and recruitment of 53BP1 (show TP53BP1 Proteins) to the DNA damage sites.

  4. The ubiquitin ligase RNF168 is strictly dependent on the activity that UbK27 is required to promote chromatin ubiquitination following DNA damage.

  5. Finding that RNF8 (show RNF8 Proteins) is less abundant than RNF168 identifies RNF8 (show RNF8 Proteins) as a rate-limiting determinant of focal repair complex assembly

  6. Depletion of RNF8 (show RNF8 Proteins) or RNF168 blocks the degradation of diffusely localized nuclear 53BP1 (show TP53BP1 Proteins).

  7. The E3 ligase RNF168 promotes both H2A ubiquitylation and neddylation. RNF168 is itself a substrate for NEDD8, and neddylation of RNF168 is necessary for its E3 ubiquitin activity.

  8. The acidic patch functions within the nucleosome as nucleosomes containing a mutated acidic patch exhibit defective H2A/H2AXub by RNF168 and RING1B (show RNF2 Proteins)/BMI1 (show BMI1 Proteins) in vitro

  9. Taken together, the results suggested that USP3 (show USP3 Proteins) is a negative regulator of ubiquitination signaling, counteracting RNF168- and RNF8 (show RNF8 Proteins)-mediated ubiquitination

  10. Before their localization to DNA double strand breaks, RNF168 interacts with 53BP1 and modifies it through the addition of a chain of ubiquitin-polypeptides.

RNF168 Protein Profile

Protein Summary

This gene encodes an E3 ubiquitin ligase protein that contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The protein is involved in DNA double-strand break (DSB) repair. Mutations in this gene result in Riddle syndrome.

Gene names and symbols associated with RNF168

  • ring finger protein 168 (Rnf168)
  • ring finger protein 168, E3 ubiquitin protein ligase (rnf168)
  • ring finger protein 168, E3 ubiquitin protein ligase (RNF168)
  • ring finger protein 168, E3 ubiquitin protein ligase (Rnf168)
  • 3110001H15Rik protein
  • hRNF168 protein

Protein level used designations for RNF168

E3 ubiquitin-protein ligase RNF168 , ring fnger protein 168

GENE ID SPECIES
70238 Mus musculus
432198 Xenopus laevis
770166 Gallus gallus
165918 Homo sapiens
488029 Canis lupus familiaris
613812 Bos taurus
690043 Rattus norvegicus
Selected quality suppliers for RNF168 Proteins (RNF168)
Did you look for something else?