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Mitochondrial E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1 (By similarity).. Additionally we are shipping RNF185 Kits (7) and RNF185 Proteins (6) and many more products for this protein.
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Chicken Polyclonal RNF185 Primary Antibody for WB - ABIN2781255
Collins, Wright, Edwards, Davis, Grinham, Cole, Goward, Aguado, Mallya, Mokrab, Huckle, Beare, Dunham: A genome annotation-driven approach to cloning the human ORFeome. in Genome biology 2004
RING finger protein (show TRIM31 Antibodies) XRNF185, which physically binds to paxillin (show PXN Antibodies) and the proteasome. XRNF185 destabilizes paxillin (show PXN Antibodies) at focal adhesions and promotes mesodermal cell migration during convergent extension.
these results indicate that RNF185 negatively regulates osteogenesis through the degradation of Dvl2 (show DVL2 Antibodies) and down-regulation of canonical Wnt (show WNT2 Antibodies) signaling pathway and suggest a possible therapeutic target in osteoporosis.
data thus identify RNF185 and RNF5 as a novel E3 ligase module that is central to the control of CFTR (show CFTR Antibodies) degradation.
Human BNIP1 colocalizes with RNF185 at mitochondria and is polyubiquitinated by RNF185 through K63-based ubiquitin linkage in vivo.
Mitochondrial E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1 (By similarity).
E3 ubiquitin-protein ligase RNF185
, RING finger protein 185