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Mitochondrial E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1 (By similarity).. Additionally we are shipping RNF185 Antibodies (35) and many more products for this protein.
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RING finger protein (show TRIM31 Proteins) XRNF185, which physically binds to paxillin (show PXN Proteins) and the proteasome. XRNF185 destabilizes paxillin (show PXN Proteins) at focal adhesions and promotes mesodermal cell migration during convergent extension.
this study uncovers RNF185 as the first E3 ubiquitin ligase (show MUL1 Proteins) of cyclic GMP (show NT5C2 Proteins)-AMP (show APRT Proteins) synthase (cGAS), shedding light on the regulation of cGAS activity in innate immune responses
these results indicate that RNF185 negatively regulates osteogenesis through the degradation of Dvl2 (show DVL2 Proteins) and down-regulation of canonical Wnt (show WNT2 Proteins) signaling pathway and suggest a possible therapeutic target in osteoporosis.
data thus identify RNF185 and RNF5 as a novel E3 ligase module that is central to the control of CFTR (show CFTR Proteins) degradation.
Human BNIP1 colocalizes with RNF185 at mitochondria and is polyubiquitinated by RNF185 through K63-based ubiquitin linkage in vivo.
Mitochondrial E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1 (By similarity).
E3 ubiquitin-protein ligase RNF185
, RING finger protein 185