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Ring Finger Protein 20 Proteins (RNF20)

The protein encoded by RNF20 shares similarity with BRE1 of S. Additionally we are shipping RNF20 Antibodies (66) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RNF20 109331 Q5DTM8
RNF20 56254 Q5VTR2
Rat RNF20 RNF20 313216  
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Top RNF20 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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RNF20 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Ring Finger Protein 20 (RNF20) Interaction Partners

Mouse (Murine) Ring Finger Protein 20 (RNF20) interaction partners

  1. RNF20 plays a critical role in the regulation of hepatic lipid metabolism by modulating the protein stability and transcriptional activity of SREBP1c (show SREBF1 Proteins) during hormonal changes.

  2. results suggested that RNF20 may play roles in adipocyte differentiation by stimulating ubiquitin-proteasome-dependent degradation of AP-2alpha (show TFAP2A Proteins).

  3. Bre1a-negative cells in the ventricular zone of early embryonic brains remain undifferentiated and are selected as self-renewing neural stem cells

  4. model whereby cotranscriptional recruitment of Rnf20 at MLL (show MLL Proteins)-fusion target genes leads to amplification of Dot1l (show DOT1L Proteins)-mediated H3K79 methylation, thereby rendering leukemia cells dependent on Rnf20 to maintain their oncogenic transcriptional program

  5. Loss of Bre1 (RNF20) disrupts gene silencing at telomeric chromatin. Most of the genomic instability in the Bre1-deficient cells is attributed to the formation of R-loops.

  6. We show that Bre1 (human BRE1A/B (RNF20/40) and mouse Bre1a/b (Rnf20/40)) acts as an important suppressor of chromosomal instability

  7. the observed defects in the radiation response of Bre1a/b-deficient cells

Human Ring Finger Protein 20 (RNF20) interaction partners

  1. It was observed that RE-IIBP induces MEIS1 (show MEIS1 Proteins)-mediated apoptosis, which was dependent on H2BK120 ubiquitination by RNF20.

  2. A primary role for FACT in RNF20 recruitment chromatin remodeling for initiation of homologous recombination repair.

  3. Together, these results indicate that human adenovirus E1A (show BCKDHA Proteins) uses hBre1 to recruit the hPaf1 (show PAF1 Proteins) complex in order to optimally activate viral early transcription by enhancing transcriptional elongation.

  4. The ability of E1A (show BCKDHA Proteins) to target hBre1 to simultaneously repress cellular IFN dependent transcription while activating viral transcription

  5. model whereby cotranscriptional recruitment of Rnf20 at MLL (show MLL Proteins)-fusion target genes leads to amplification of Dot1l (show DOT1L Proteins)-mediated H3K79 methylation, thereby rendering leukemia cells dependent on Rnf20 to maintain their oncogenic transcriptional program

  6. We show that Bre1 (human BRE1A/B (RNF20/40) and mouse Bre1a/b (Rnf20/40)) acts as an important suppressor of chromosomal instability

  7. our results suggest that RNF20 and RNF40, either via ubiquitylation of H2B or other targets, are coupled to the proliferation of prostate cancer cells.

  8. Studies indicate that H2B monoubiquitylation is driven primarily by an E3 ubiquitin ligase (show MUL1 Proteins) composed of the two RING finger (show PCGF1 Proteins) proteins RNF20 and RNF40 (show RNF40 Proteins).

  9. RNF20, presumably via H2Bub, selectively represses oncogenic genes by interfering with chromatin recruitment of TFIIS (show TCEA1 Proteins), a factor capable of relieving stalled RNA polymerase II. RNF20 inhibits the interaction between TFIIS (show TCEA1 Proteins) and the PAF1 (show PEX2 Proteins) complex.

  10. RNF20-mediated H2B ubiquitination at DSBs plays a critical role in HRR through chromatin remodeling

RNF20 Protein Profile

Protein Summary

The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS).

Gene names and symbols associated with Ring Finger Protein 20 Proteins (RNF20)

  • ring finger protein 20 (RNF20)
  • ring finger protein 20 (Rnf20)
  • ring finger protein 20, E3 ubiquitin protein ligase (RNF20)
  • ring finger protein 20, E3 ubiquitin protein ligase (Rnf20)
  • 4833430L21Rik protein
  • AW540162 protein
  • BRE1 protein
  • BRE1A protein
  • C79397 protein
  • hBRE1 protein
  • mKIAA4116 protein

Protein level used designations for Ring Finger Protein 20 Proteins (RNF20)

BRE1-A , E3 ubiquitin-protein ligase BRE1A , BRE1 E3 ubiquitin ligase homolog , homolog of S. cerevisiae BRE1

GENE ID SPECIES
513326 Bos taurus
109331 Mus musculus
56254 Homo sapiens
427310 Gallus gallus
474788 Canis lupus familiaris
313216 Rattus norvegicus
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