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RNF216 encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Additionally we are shipping RNF216 Antibodies (73) and and many more products for this protein.
Low RNF216 expression is associated with obesity-induced inflammation.
missense mutations in TRIAD3 abolished the interaction of TRIAD3A with Arc (show NOL3 ELISA Kits), disrupting Arc (show NOL3 ELISA Kits) ubiquitination, and consequently Arc (show NOL3 ELISA Kits) degradation.
identifies a novel negative regulator of autophagy and suggests that RNF216 may be a target for treatment of inflammatory diseases
Novel RNF216 mutations causing an Huntington (show HTT ELISA Kits)-like phenotype with pure monogenic recessive inheritance. .
Loss of Triad3A mimics and occludes Arc (show NOL3 ELISA Kits)-dependent forms of synaptic plasticity.
The syndrome of hypogonadotropic hypogonadism, ataxia, and dementia can be caused by inactivating mutations in RNF216 or by the combination of mutations in RNF216 and OTUD4 (show OTUD4 ELISA Kits).
By promoting polyubiquitylation and degradation, E3 ubiquitin ligase Triad3A is identified as an interaction partner for the killer cell Ig-like receptor KIR2DL4 (show KIR2DL4 ELISA Kits) cytoplasmic domain.
Triad3A represents a versatile E3 ubiquitin ligase that negatively regulates RIG (show DIRAS1 ELISA Kits)-like receptor signaling by targeting TRAF3 (show TRAF3 ELISA Kits) for degradation following RNA virus infection.
interacts with RIP (show HRB ELISA Kits) and inhibits tnf (show TNF ELISA Kits) and il1 (show IL1A ELISA Kits)-induced NFKB activation
ZIN binds to purified Vif (show BTG1 ELISA Kits) in vitro and Triad 3/ZIN interacts with HIV-1 Vif (show BTG1 ELISA Kits) in transfected human 293T cells, as demonstrated by coimmunoprecipitation
Triad3A regulates ubiquitination and proteasomal degradation of RIP1 following disruption of Hsp90 (show HSP90 ELISA Kits) binding and play a crucial role in innate immunity
Gene expression of RIPK3 (show RIPK3 ELISA Kits) and RNF216 in PBMC could identify those obese subjects, who will regain more weight after a successful initial weight loss. The mRNA levels of these genes could be nutrigenomic biomarkers for predicting obesity treatment outcome.
This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known.
E3 ubiquitin-protein ligase RNF216
, ring finger protein 216
, TRIAD3 protein
, E3 ubiquitin ligase
, triad domain-containing protein 3
, ubcM4-interacting protein 83
, ubiquitin-conjugating enzyme 7-interacting protein 1
, zinc finger protein inhibiting NF-kappa-B