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The protein encoded by RNF31 contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. Additionally we are shipping RNF31 Proteins (3) and RNF31 Kits (1) and many more products for this protein.
Showing 10 out of 69 products:
Cow (Bovine) Polyclonal RNF31 Primary Antibody for WB - ABIN2774753
Kirisako, Kamei, Murata, Kato, Fukumoto, Kanie, Sano, Tokunaga, Tanaka, Iwai: A ubiquitin ligase complex assembles linear polyubiquitin chains. in The EMBO journal 2006
Show all 9 Pubmed References
Human Polyclonal RNF31 Primary Antibody for ELISA, WB - ABIN249637
Varfolomeev, Izrael-Tomasevic, Yu, Bustos, Goncharov, Belmont, Masselot, Bakalarski, Kirkpatrick, Vucic: Ubiquitination profiling identifies sensitivity factors for IAP antagonist treatment. in The Biochemical journal 2015
Show all 4 Pubmed References
This review highlights recent discoveries on RNF31 functions in nuclear factor modifications, breast cancer progression and possible therapeutic inhibitors targeting RNF31. [review]
The data reveal SPATA2 (show SPATA2 Antibodies) as a high-affinity binding partner of CYLD (show CYLD Antibodies) and HOIP, and a regulatory component of linear ubiquitin chain assembly complex-mediated NF-kappaB (show NFKB1 Antibodies) signaling.
LUBAC components control TLR3 (show TLR3 Antibodies)-mediated innate immunity, thereby preventing development of immunodeficiency and autoinflammation.
Study found that RNF31 is cleaved under apoptosis conditions through various stimulations; findings elucidate a novel regulatory loop between cell death and the survival signal
These results indicate that caspase (show CASP3 Antibodies)-mediated cleavage of HOIP divides critical functional regions of HOIP, and that this regulates linear (de)ubiquitination of substrates upon apoptosis.
RNF31 decreased p53 (show TP53 Antibodies) stability. RNF31 depletion caused cell cycle arrest and cisplatin-induced apoptosis in a p53 (show TP53 Antibodies)-dependent manner. RNF31 associated with the p53 (show TP53 Antibodies)/MDM2 (show MDM2 Antibodies) complex, facilitating p53 (show TP53 Antibodies) polyubiquitination and degradation by stabilizing MDM2 (show MDM2 Antibodies).
This study describes a novel posttranslational regulation of the HOIP-containing linear-ubiquitin-chain assembly complex (LUBAC)-mediated linear ubiquitination that is critical for specifically directing TLR4 (show TLR4 Antibodies)-mediated NF-kappaB (show NFKB1 Antibodies) activation.
These findings collectively indicated an oncogene (show RAB1A Antibodies) role of RNF31 in PCa (show FLVCR1 Antibodies) progression which can be regulated by miR (show MLXIP Antibodies)-503, suggesting that RNF31 could serve as a potential prognostic biomarker and therapeutic target for PCa (show FLVCR1 Antibodies).
we identified BCL10 (show BCL10 Antibodies) as a bona fide target of BCR (show BCR Antibodies)-induced linear ubiquitylation and demonstrated an important role of the linear ubiquitin ligase HOIP in BCR (show BCR Antibodies)-induced phosphorylation
crystal structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation
HOIP's catalytic activity is necessary for preventing TNF (show TNF Antibodies)-induced cell death. Hence, LUBAC and its linear-ubiquitin-forming activity are required for maintaining vascular integrity during embryogenesis by preventing TNFR1 (show TNFRSF1A Antibodies)-mediated endothelial cell death.
Restoration of HOIP expression reversed the defects in cellular activation and signaling. These results reveal HOIP as a key component of the CD40 (show CD40 Antibodies) signaling pathway
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions.
ring finger protein 31
, E3 ubiquitin-protein ligase RNF31
, HOIL-1-interacting protein
, zinc in-between-RING-finger ubiquitin-associated domain protein
, RING finger protein 31
, putative Ariadne-like ubiquitin ligase