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Ring Finger Protein 4 Proteins (RNF4)

The protein encoded by RNF4 contains a RING finger motif and acts as a transcription regulator. Additionally we are shipping RNF4 Kits (29) and RNF4 Antibodies (25) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RNF4 6047 P78317
RNF4 19822 Q9QZS2
RNF4 29274 O88846
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Top RNF4 Proteins at antibodies-online.com

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,467.67
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$413.21
Details

RNF4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced RNF4 Proteins

  1. Human RNF4 Protein expressed in Escherichia coli (E. coli) - ABIN1098423 : Guo, Sharrocks et al.: Extracellular signal-regulated kinase mitogen-activated protein kinase signaling initiates a dynamic interplay between sumoylation and ubiquitination to regulate the activity of the transcriptional ... in Molecular and cellular biology 2009 (PubMed)
    Show all 2 references for ABIN1098423

More Proteins for Ring Finger Protein 4 (RNF4) Interaction Partners

Human Ring Finger Protein 4 (RNF4) interaction partners

  1. c-Myc (show MYC Proteins) is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1 (show PIAS1 Proteins), SENP7 (show SENP7 Proteins) and RNF4

  2. Data show that RNF4 is a SUMO-targeted ubiquitin ligase that targets TRF2 (show TERF2 Proteins) for ubiquitination.

  3. novel insight into cross-talk between ubiquitin and SUMO and uncover USP11 and RNF4 as a balanced SUMO-targeted ubiquitin ligase/protease pair with a role in the DDR (show DDR1 Proteins).

  4. RNF4 negatively regulates NF-kappaB (show NFKB1 Proteins) signaling by down-regulating TAB2 (show TAB2 Proteins)

  5. RNF4 enhances Ube2E1 (show UBE2E1 Proteins) self-ubiquitination.

  6. NMR spectroscopy and biochemical characterization reveal how RNF4 manipulates the conformation of the SUMO chain, thereby facilitating optimal delivery of the distal SUMO domain for ubiquitin transfer.

  7. RecQ-like helicase BLM subcellular localization is regulated by SUMO-targeted ubiquitin ligase RNF4 in response to DNA damage, presumably to prevent illegitimate recombination events.

  8. Cells lacking RNF4 exhibited interstrand cross-linker hypersensitivity. The gene encoding RNF4 was epistatic with the other genes encoding members of the FA/BRCA pathway.

  9. RNF4 mediates ubiquitination and turnover of MeCP2 (show MECP2 Proteins) and thus derepresses transcription from DNA methylation (show HELLS Proteins).

  10. the ARM dynamically regulates the SIM (show SIM2 Proteins)-dependent recruitment of targets to RNF4, which could be critical to dynamically fine-tune the abundance of Ser (show SIGLEC1 Proteins)(P)-824-SUMO-KAP1 (show CDKN3 Proteins) and, potentially, other SUMOylated proteins during DNA damage response.

Mouse (Murine) Ring Finger Protein 4 (RNF4) interaction partners

  1. This paper identifies a nucleosome-targeting motif within the RNF4 RING domain that can bind DNA and thereby enables RNF4 to selectively ubiquitinate nucleosomal histones.

  2. fork collapse in Atr-deleted cells is mediated through the combined effects the sumo targeted E3-ubiquitin ligase RNF4 and activation of the AURKA-PLK1 pathway

  3. Rnf4 controls protein localization at DNA damage sites by integrating SUMOylation and ubiquitylation events.

  4. SUMO interacting motif is dispensable for PML (show PML Proteins) SUMOylation and interaction with RNF4 but is required for efficient PML (show PML Proteins) ubiquitination, recruitment of proteasome components within NBs (show NLRP2 Proteins) and proteasome-dependent degradation of PML (show PML Proteins) in response to AsO

  5. Rnf4 deficiency is embryonic lethal with higher levels of methylation in genomic DNA. Mechanistic studies show that RNF4 interacts with and requires the base excision repair enzymes TDG (show TDG Proteins) and APE1 (show APEX1 Proteins) for active demethylation.

  6. GC-rich (show RELB Proteins) elements flanking the transcription start site govern activation

  7. 1.6- and 3.0-kb transcripts originate from the same promoter, encode for the same protein and differ in the 3' UTR.

  8. RNF4 is a negative regulator of TRPS1 activity

  9. results suggest a role for small nuclear ring finger protein(SNURF/RNF4) in fetal germ cell development as well as in oocyte and granulosa cell maturation in an estrogen- and gonadotropin-regulated fashion

  10. Rnf4 possesses ubiquitin E3 ligase activity.

RNF4 Protein Profile

Protein Summary

The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.

Gene names and symbols associated with Ring Finger Protein 4 Proteins (RNF4)

  • ring finger protein 4 (RNF4)
  • ring finger protein 4 (Rnf4)
  • ring finger protein 4 (LOC100348357)
  • AU018689 protein
  • Gtrgeo8 protein
  • SLX5 protein
  • SNURF protein

Protein level used designations for Ring Finger Protein 4 Proteins (RNF4)

E3 ubiquitin ligase RNF4 , E3 ubiquitin-protein ligase RNF4 , small nuclear RING finger protein , gene trap ROSA b-geo 8 , SNURF , small nuclear ring finger protein , RING finger protein 4

GENE ID SPECIES
6047 Homo sapiens
19822 Mus musculus
29274 Rattus norvegicus
100348357 Oryctolagus cuniculus
100735750 Cavia porcellus
692189 Sus scrofa
617018 Bos taurus
101110510 Ovis aries
610552 Canis lupus familiaris
422886 Gallus gallus
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