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RNF43 is a HAP95 (AKAP8L\; MIM 609475) binding ubiquitin ligase that promotes cell growth and is upregulated in colon cancer (Yagyu et al., 2004 [PubMed 15492824]\; Sugiura et al., 2008 [PubMed 18313049]).[supplied by OMIM, Dec 2008].. Additionally we are shipping RNF43 Antibodies (23) and many more products for this protein.
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Authors also identified ring finger (show PCGF1 Proteins) 43 (RNF43), an inhibitor of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling, as a target of miR (show MLXIP Proteins)-550a-5p.
RNF43 inhibits the Wnt (show WNT2 Proteins) pathway downstream of oncogenic mutations that activate the pathway.
RNF43 might act as a tumor suppressor in gastric carcinoma and might be a potential indicator for the clinical assessment of gastric cancer prognosis
RNF43 gene harbored not only exceedingly high mutations but also mutational intratumoral heterogeneity, which together might play a role in tumorigenesis of gastric and colorectal cancers.
The nucleoprotein of influenza A virus targets RNF43 to modulate p53 (show TP53 Proteins) ubiquitination levels and hence causes p53 (show TP53 Proteins) stabilization which is conducive to an enhanced apoptosis level in the host cells.
we found that the decreased expression of RNF43 in glioma was associated with poor prognosis by the Kaplan-Meier survival analysis. Importantly, multivariate analysis suggested RN43 as an independent predictor of overall survival.
These results indicate that RNF43 mutation might cause downregulation of the expression of ring finger protein 43 and play a crucial role during development of intraductal papillary mucinous neoplasm of the pancreas.
Data indicate Dishevelled (DVL (show DVL2 Proteins)) as a dual function adaptor to recruit negative regulators ZNRF3 (show ZNRF3 Proteins)/RNF43 to Wnt (show WNT2 Proteins) receptors to ensure proper control of pathway activity.
Missense mutations of RNF43 change their localization from the endosome to the endoplasmic reticulum.
RNF43 is one of the most commonly mutated genes in colorectal and endometrial cancers
RNF43 and ZNRF3 (show ZNRF3 Proteins) reduce Wnt (show WNT2 Proteins) signals by selectively ubiquitinating frizzled receptors, thereby targeting these Wnt (show WNT2 Proteins) receptors for degradation
RNF43 is a HAP95 (AKAP8L\; MIM 609475) binding ubiquitin ligase that promotes cell growth and is upregulated in colon cancer (Yagyu et al., 2004
E3 ubiquitin-protein ligase RNF43
, RING finger protein 43