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Ring Finger Protein 8 Proteins (RNF8)

The protein encoded by RNF8 contains a RING finger motif and an FHA domain. Additionally we are shipping Ring Finger Protein 8 Antibodies (93) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RNF8 58230 Q8VC56
RNF8 9025 O76064
RNF8 361815 Q4KLN8
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Top Ring Finger Protein 8 Proteins at

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days

RNF8 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
Rat (Rattus)

Top referenced Ring Finger Protein 8 Proteins

  1. Human RNF8 Protein expressed in Wheat germ - ABIN1318397 : Delker, Zhou, Strikoudis, Stebbins, Papavasiliou: Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase. in Proceedings of the National Academy of Sciences of the United States of America 2013 (PubMed)
    Show all 2 references for ABIN1318397

More Proteins for Ring Finger Protein 8 (RNF8) Interaction Partners

Mouse (Murine) Ring Finger Protein 8 (RNF8) interaction partners

  1. RNF8(-/-) mice exhibit neuronal degeneration and reactive astrocytosis. Neurons from RNF8(-/-) mice appear to be more susceptible to X-ray-induced DNA damage

  2. Altogether, the data in this study highlight the importance of p53 (show TP53 Proteins)-pathway activation upon loss of Rnf8, suggesting that Rnf8 and p53 (show TP53 Proteins) functionally interact to protect against genomic instability and tumorigenesis.

  3. The identification of RNF8 allows new insights into the integration of the control of p12 (show CDK2AP1 Proteins) degradation by different DNA damage signaling pathways.

  4. RNF8-dependent ubiquitination of histone H2A during meiosis establishes active epigenetic modifications, including dimethylation of H3K4 on the sex chromosomes

  5. A new mechanism of chromatin remodelling-assisted ubiquitylation was shown, which involves cooperation between CHD4 (show CHD4 Proteins) and RNF8 to create a local chromatin environment permissive to the assembly of checkpoint and repair machineries at DNA lesions.

  6. Rnf8 physically interacts with Tpp1 (show TPP1 Proteins) to generate Ubc13 (show UBE2N Proteins)-dependent Lys63 polyubiquitin (show UBB Proteins) chains that stabilize Tpp1 (show TPP1 Proteins) at telomeres.

  7. RNF8 and Chfr (show CHFR Proteins), function together to activate ATM (show ATM Proteins) and maintain genomic stability in vivo.

  8. 53BP1 (show TP53BP1 Proteins) protein binds to Rnf8, suggesting DNA damage involves RNF8 dependent ubiquitylation, which allows its accumulation at damaged chromatin.

  9. RNF8 deficint mice exhibit increased genomic instability and elevated risks for tumorigenesis indicating that Rnf8 is a novel tumor suppressor.

  10. investigate the role of the ubiquitin ligase (show RNF123 Proteins) RNF8 during spermatogenesis and find that RNF8-deficient mice are proficient in meiotic sex chromosome inactivation but deficient in global nucleosome removal

Human Ring Finger Protein 8 (RNF8) interaction partners

  1. The interaction of MDC1 with RNF8, but not with ATM (show ATM Proteins) requires WRAP53beta, suggesting that WRAP53beta facilitates the former interaction without altering phosphorylation of MDC1 by ATM (show ATM Proteins).

  2. These findings elucidate deeply and extensively the mechanism of RNF8/RNF168 (show RNF168 Proteins) and USP11 to maintain the proper status of ubiquitylation gammaH2AX (show H2AFX Proteins) to repair double strand breaks.

  3. define a novel function for ATDC (show TRIM29 Proteins) in the RNF8-mediated DNA damage response and implicate RNF8 binding as a key determinant of the radioprotective function of ATDC (show TRIM29 Proteins)

  4. Results indicate that RNF8 recruits and ubiquitinates many factors to repair DNA damage thereby conferring radioresistance to nasopharyngeal cancer cells.

  5. Significantly restored tolerance of RAD18 (show RAD18 Proteins)-/- and RNF8-/- cells to camptothecin and olaparib without affecting Rad51 (show RAD51 Proteins) focus formation.

  6. considered potential associations of 14 single nucleotide polymorphisms (SNPs) in RNF8 and BRDT (show BRDT Proteins) genes in Chinese patients with non-obstructive azoospermia

  7. our results indicate that down-regulation of RNF8 mediated by miR (show MLXIP Proteins)-214 impedes DNA damage response to induce chromosomal instability in ovarian cancers, which may facilitate the understanding of mechanisms underlying chromosomal instability.

  8. Finding that RNF8 is less abundant than RNF168 (show RNF168 Proteins) identifies RNF8 as a rate-limiting determinant of focal repair complex assembly.

  9. Depletion of RNF8 or RNF168 (show RNF168 Proteins) blocks the degradation of diffusely localized nuclear 53BP1 (show TP53BP1 Proteins).

  10. PALB2 localization depends on the presence of MDC1, RNF8, RAP80 and Abraxas upstream of BRCA1.

Ring Finger Protein 8 (RNF8) Protein Profile

Protein Summary

The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with Ring Finger Protein 8 Proteins (RNF8)

  • ring finger protein 8 (RNF8)
  • ring finger protein 8 (Rnf8)
  • ring finger protein 8, E3 ubiquitin protein ligase (RNF8)
  • ring finger protein 8, E3 ubiquitin protein ligase (rnf8-a)
  • ring finger protein 8, E3 ubiquitin protein ligase (Rnf8)
  • ring finger protein 8, E3 ubiquitin protein ligase (rnf8)
  • 3830404E21Rik protein
  • AIP37 protein
  • fc66f09 protein
  • hRNF8 protein
  • RNF8 protein
  • wu:fc66f09 protein
  • zgc:55936 protein
  • zgc:77313 protein

Protein level used designations for Ring Finger Protein 8 Proteins (RNF8)

E3 ubiquitin-protein ligase RNF8 , ActA binding protein 2 , actA-interacting protein 37 , laXp180 , C3HC4-type zinc finger protein , UBC13/UEV-interacting ring finger protein , ring finger protein (C3HC4 type) 8 , E3 ubiquitin-protein ligase RNF8 A , E3 ubiquitin-protein ligase RNF8-A , RING finger protein 8 A , RING finger protein 8-A

515933 Bos taurus
58230 Mus musculus
9025 Homo sapiens
380076 Xenopus laevis
361815 Rattus norvegicus
481775 Canis lupus familiaris
100173982 Pongo abelii
404050 Danio rerio
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