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The protein encoded by RCHY1 has ubiquitin ligase activity. Additionally we are shipping Ring Finger and CHY Zinc Finger Domain Containing 1, E3 Ubiquitin Protein Ligase Antibodies (53) and Ring Finger and CHY Zinc Finger Domain Containing 1, E3 Ubiquitin Protein Ligase Proteins (5) and many more products for this protein.
p27 (show PAK2 ELISA Kits) and its cognate ubiquitin ligases, Skp2/KPC/Pirh2, are specifically involved in determining the clinical profiles of lung carcinomas.
Decrease of PIRH2 expression in the breast cancer cell line MDA-MB-231 resulted in reduced tumor cell growth via the inhibition of cell proliferation and the interruption of cell cycle transition.
The Hoxa2 (show HOXA2 ELISA Kits)-mediated decay of RCHY1 involves both the 19S and 20S proteasome (show PSMA5 ELISA Kits) complexes
Tumor suppressor p63 (show RPE65 ELISA Kits) regulates expression of ubiquitin ligase PIRH2.
Overexpression of Pirh2 decreased the replication of prototype foamy virus, whereas knockdown of Pirh2 with specific siRNA increased PFV replication.
Findings indicate that PIRH2 has central roles in the ubiquitylation of Chk2 (show CHEK2 ELISA Kits) and its turnover and in the regulation of its function.
Pirh2 has a physiologically relevant role in keratinocyte differentiation through the posttranslational modification of p63 (show RPE65 ELISA Kits) protein.
suggested that the interaction of SCYL1BP1 (show GORAB ELISA Kits)/Pirh2 could accelerate Pirh2 degradation through an ubiquitin-dependent pathway. SCYL1BP1 (show GORAB ELISA Kits) may function as an important tumor suppressor gene in HCC (show FAM126A ELISA Kits) development
Compared to full-length PIRH2A, PIRH2E lacks amino acids 235-261, while PIRH2F is missing C-terminal amino acids 227-261 and both isoforms harbor the RING domain.
low expression of human PIRH2 in lung, ovarian, and breast cancers co (show TP53 ELISA Kits)rrelates w (show MYC ELISA Kits)ith decreased patients' survival
This study provides evidence that the ubiquitination of p73 (show ARHGAP24 ELISA Kits) mediated by Pirh2 represents an important pathway for controlling the suppressive function of p73 (show ARHGAP24 ELISA Kits)
these data reveal the in vivo roles of Pirh2 in the regulation of p53 (show TP53 ELISA Kits) and c-Myc (show MYC ELISA Kits) stability and support its role as a tumor suppressor
Data show that Pirh2 monoubiquitinates PolH (show POLH ELISA Kits) at one of multiple lysine residues, and that monoubiquitination of PolH (show POLH ELISA Kits) inhibits its ability to interact with PCNA (show PCNA ELISA Kits) and bypass UV-induced lesions, leading to decreased viability.
cloning and characterization of an androgen receptor N-terminal-interacting protein with ubiquitin-protein ligase (show UBE2K ELISA Kits) activity [androgen-receptor N-terminal-interacting protein; mARNIP]
Pirh2 (Zfp363), a gene regulated by p53 (show TP53 ELISA Kits), encodes a RING-H2 domain-containing protein with intrinsic ubiquitin-protein ligase (show UBE2K ELISA Kits) activity. Pirh2 physically interacts with p53 (show TP53 ELISA Kits) and promotes ubiquitination and degradation of p53 (show TP53 ELISA Kits) independently of Mdm2 (show MDM2 ELISA Kits).
These results are consistent with the hypothesis that increased Pirh2 expression affects lung tumorigenesis by reducing p53 (show TP53 ELISA Kits) activity.
Pirh2 acts as a negative regulator of p27(Kip1 (show CDKN1B ELISA Kits)) function by promoting ubiquitin-dependent proteasomal degradation
This study showed that ORF3 (show ASZ1 ELISA Kits) protein of porcine circovirus type 2 interacted competitively with p53 tumor suppressor protein (show TP53 ELISA Kits) in binding to porcine Pirh2.
Results show that the PCV2 ORF3 (show ASZ1 ELISA Kits) protein specifically interacts with pPirh2 and inhibits its stabilization; this may lead to increasing p53 (show TP53 ELISA Kits) expression, resulting in apoptosis.
The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including TP53, HDAC1 and CDKN1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
CH-rich interacting match with PLAG1
, E3 ubiquitin-protein ligase Pirh2
, RING finger and CHY zinc finger domain-containing protein 1
, RING finger protein 199
, androgen-receptor N-terminal-interacting protein
, p53-induced protein with a RING-H2 domain
, zinc finger protein 363
, CH-rich-interacting match with PLAG1
, androgen receptor N-terminal-interacting protein
, ring finger and CHY zinc finger domain containing 1