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Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2) ELISA Kits

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. Additionally we are shipping RFWD2 Antibodies (77) and RFWD2 Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
RFWD2 26374 Q9R1A8
Anti-Rat RFWD2 RFWD2 689375  
RFWD2 64326 Q8NHY2
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Top RFWD2 ELISA Kits at antibodies-online.com

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Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Human
96 Tests Log in to see 2 to 3 Days
$480.00
Details

More ELISA Kits for RFWD2 Interaction Partners

Arabidopsis thaliana Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2) interaction partners

  1. Data indicate a coordinated regulation of Arabidopsis proteins SHW1, COP1, and HY5 in seedling development.

  2. The COP1 role in CONSTANS protein degradation during photoperiodic flowering

  3. CSU2 interacts with COP1 via the coiled-coil domain association. CSU2 negatively regulates COP1 E3 ubiquitin ligase activity. [COP1]

  4. propose that light perceived by phytochromes causes a switch in the ubiquitination activity of COP1/SPA2 from ubiquitinating downstream substrates to ubiquitinating SPA2, which subsequently causes a repression of COP1/SPA2 function

  5. CUL4(COP1-SPA) E3 ubiquitin ligase is necessary for the light-induced degradation of PIF1 in Arabidopsis.

  6. genetic analyses with transgenes expressing a genomic pmARI12:ARI12-GFP construct confirm the epistatic interaction between COP1 and ARI12 in growth responses to high fluence rate UV-B.

  7. Interaction of phyB with SPA1 promotes COP1-SPA1 dissociation and photomorphogenic development.

  8. AN3 may act with other proteins that bind to COP1 promoter to promote anthocyanin accumulation and inhibit light-induced root elongation.

  9. Two distinct domains of the UVR8 photoreceptor interact with COP1 to initiate UV-B signaling in Arabidopsis

  10. The Transcriptional Regulator BBX19 Promotes Hypocotyl Growth by Facilitating COP1-Mediated EARLY FLOWERING3 Degradation in Arabidopsis

Mouse (Murine) Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2) interaction partners

  1. Study shows that post-translational regulation of the transcription factors ETV1, ETV4, and ETV5 by the ubiquitin ligase COP1 (also called RFWD2) in beta cells is critical for insulin secretion. Mice lacking COP1 in beta cells developed diabetes due to insulin granule docking defects that were fully rescued by genetic deletion of Etv1, Etv4, and Etv5.

  2. These results indicate that COP1 and Trib1 (show TRIB1 ELISA Kits) act as an oncoprotein complex functioning upstream of C/EBPalpha (show CEBPA ELISA Kits), and its ligase activity is crucial for leukemogenesis.

  3. COP1 physically interacted with PTP1B (show PTPN1 ELISA Kits) and suppressed PTP1B (show PTPN1 ELISA Kits) phosphatase activity as well as the association of PTP1B (show PTPN1 ELISA Kits) with IRbeta.

  4. Modulation of fatty acid synthase (show FASN ELISA Kits) degradation by concerted action of p38 MAP kinase (show MAPK14 ELISA Kits), E3 ligase COP1, and SH2-tyrosine phosphatase Shp2 (show PTPN11 ELISA Kits).

  5. the ubiquitin ligase (show RNF123 ELISA Kits) COP1 (also known as RFWD2) is a tumour suppressor that negatively regulates ETV1 (show ETV1 ELISA Kits), ETV4 (show ETV4 ELISA Kits) and ETV5; ETV1 (show ETV1 ELISA Kits), which is mutated in prostate cancer more often, was degraded after being ubiquitinated by COP1

  6. Cop1 is a tumor suppressor that functions, at least in part, by antagonizing c-Jun (show JUN ELISA Kits) oncogenic activity.

  7. Rfwd2 is associated with acute lung injury

  8. description of a pathway in which Tribbles 3 (TRB3 (show TRIB3 ELISA Kits)) stimulates lipolysis by triggering the degradation of acetyl-coenzyme A carboxylase (ACC (show ACACA ELISA Kits)) in adipose tissue; TRB3 (show TRIB3 ELISA Kits) promoted ACC (show ACACA ELISA Kits) ubiquitination through an association with the E3 ubiquitin ligase COP1

  9. Disruption of the COP1-mediated proteolysis by ionizing radiation leads to MTA1 (show MTA1 ELISA Kits) stabilization.

Human Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2) interaction partners

  1. the present study revealed that COP1 (show CARD16 ELISA Kits) plays an important role in CLL cell proliferation and tumorigenicity, and may be a useful indicator of the chronic lymphocytic leukemia processes.

  2. COP1 (show CARD16 ELISA Kits) directly interacts with p27 (show PAK2 ELISA Kits) through a VP motif on p27 (show PAK2 ELISA Kits) and functions as an E3 ligase of p27 (show PAK2 ELISA Kits) to accelerate the ubiquitin-mediated degradation of p27 (show PAK2 ELISA Kits). COP1 (show CARD16 ELISA Kits)-p27 (show PAK2 ELISA Kits) axis deregulation is involved in tumorigenesis.

  3. COP1 (show CARD16 ELISA Kits) overexpression leads to the cytoplasmic distribution of p27 (show PAK2 ELISA Kits), thereby accelerating p27 (show PAK2 ELISA Kits) degradation.

  4. COP1 (show CARD16 ELISA Kits) negatively regulates ETV1 (show ETV1 ELISA Kits) in patients with triple-negative breast cancer.

  5. TRIB2 (show TRIB2 ELISA Kits) associated-ubiquitin E3 ligases beta-transducin repeat-containing E3 ubiquitin protein ligase (beta-TrCP (show BTRC ELISA Kits)), COP1 (show CARD16 ELISA Kits) and Smad ubiquitination regulatory factor 1 (Smurf1 (show SMURF1 ELISA Kits)) reduced TCF4 (show TCF4 ELISA Kits)/beta-Catenin (show CTNNB1 ELISA Kits) expression, and these effects could be enhanced by TRIB2 (show TRIB2 ELISA Kits).

  6. Phosphorylation of the ETS1 (show ETS1 ELISA Kits) and ETS2 (show ETS2 ELISA Kits) transcriptional oncoproteins at specific serine or threonine residues creates binding sites for the COP1 (show CARD16 ELISA Kits) tumor suppressor protein (show TP53 ELISA Kits).

  7. while the role of COP1 (show CARD16 ELISA Kits) in malignancies is controversial, our current data support that COP1 (show CARD16 ELISA Kits) acts as a tumor suppressor in gastric cancer.

  8. co-expressing COP1 and active GSK3beta blocked in vitro cell growth/migration and in vivo metastasis of invasive breast cancer cells.

  9. COP1 (show CARD16 ELISA Kits) physically interacted with PTP1B (show PTPN1 ELISA Kits) and suppressed PTP1B (show PTPN1 ELISA Kits) phosphatase activity as well as the association of PTP1B (show PTPN1 ELISA Kits) with IRbeta.

  10. Modulation of fatty acid synthase (show FASN ELISA Kits) degradation by concerted action of p38 MAP kinase (show MAPK14 ELISA Kits), E3 ligase COP1 (show CARD16 ELISA Kits), and SH2-tyrosine phosphatase Shp2 (show PTPN11 ELISA Kits).

RFWD2 Antigen Profile

Antigen Summary

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1 (By similarity).

Gene names and symbols associated with RFWD2

  • E3 ubiquitin-protein ligase COP1 (COP1) antibody
  • ring finger and WD repeat domain 2 (Rfwd2) antibody
  • ring finger and WD repeat domain 2-like 1 (Rfwd2l1) antibody
  • ring finger and WD repeat domain 2, E3 ubiquitin protein ligase (RFWD2) antibody
  • AI316802 antibody
  • ARABIDOPSIS THALIANA CONSTITUTIVE PHOTOMORPHOGENIC 1 antibody
  • ATCOP1 antibody
  • C80879 antibody
  • CONSTITUTIVE PHOTOMORPHOGENIC 1 antibody
  • COP1 antibody
  • DEETIOLATED MUTANT 340 antibody
  • DET340 antibody
  • EMB168 antibody
  • EMBRYO DEFECTIVE 168 antibody
  • FUS1 antibody
  • FUSCA 1 antibody
  • Rfwd2 antibody
  • RNF200 antibody
  • T21L14.11 antibody
  • T21L14_11 antibody

Protein level used designations for RFWD2

E3 ubiquitin-protein ligase RFWD2 , RING finger and WD repeat domain protein 2 , constitutive photomorphogenesis protein 1 homolog , constitutive photomorphogenic protein 1 , mCOP1 , ring finger and WD repeat domain 2-like 1 , ring finger and WD repeat domain 2 , RING finger protein 200 , constitutive photomorphogenic protein (COP1) , hCOP1 , putative ubiquitin ligase COP1

GENE ID SPECIES
817857 Arabidopsis thaliana
26374 Mus musculus
689375 Rattus norvegicus
64326 Homo sapiens
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