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RFWD2 Proteins

(Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2))
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1 (By similarity).
RFWD2 Protein (AA 632-731) (GST tag) RFWD2 Protein (AA 632-731) (GST tag) RFWD2 Protein (AA 632-731) (GST tag) (ABIN1317872)

RFWD2 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA

RFWD2 Protein (AA 1-731) (His tag) RFWD2 Protein (AA 1-731) (His tag) RFWD2 Protein (AA 1-731) (His tag) (ABIN3095004)

Crystallography grade RFWD2 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, Crys, SDS

RFWD2 Protein (AA 1-733) (His tag) RFWD2 Protein (AA 1-733) (His tag) RFWD2 Protein (AA 1-733) (His tag) (ABIN3137447)

Crystallography grade RFWD2 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, Crys, SDS

RFWD2 Proteins by Grade

Find RFWD2 Proteins with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

RFWD2 Proteins by Origin

Find RFWD2 Proteins for a variety of species such as anti-Human RFWD2, anti-Mouse RFWD2. The species listed below are among those available. Click on a link to go to the corresponding products.

RFWD2 Proteins by Source

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RFWD2 Proteins by Protein Type

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RFWD2 Proteins by Application

Find RFWD2 Proteins validated for a specific application such as ELISA, WB, AbP, SDS. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular RFWD2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1317872
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3095004
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3137447
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2730790
Quantity 20 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2730791
Quantity 20 μg
Datasheet Datasheet

Aliases for RFWD2 Proteins

ring finger and WD repeat domain 2 (RFWD2) Proteins
ring finger and WD repeat domain 2 (Rfwd2) Proteins
ring finger and WD repeat domain 2, E3 ubiquitin protein ligase (rfwd2) Proteins
ring finger and WD repeat domain 2, E3 ubiquitin protein ligase L homeolog (rfwd2.L) Proteins
ring finger and WD repeat domain 2 (rfwd2) Proteins
AI316802 Proteins
C80879 Proteins
COP1 Proteins
Cop1 Proteins
cop1 Proteins
RFWD2 Proteins
RGD1304773 Proteins
RNF200 Proteins
rnf200 Proteins
zgc:163067 Proteins
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