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Ring Finger and WD Repeat Domain 3 Proteins (RFWD3)

E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. Additionally we are shipping RFWD3 Antibodies (25) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat RFWD3 RFWD3 361409  
RFWD3 55159 Q6PCD5
RFWD3 234736 Q8CIK8
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Top RFWD3 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

RFWD3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Ring Finger and WD Repeat Domain 3 (RFWD3) Interaction Partners

Horse (Equine) Ring Finger and WD Repeat Domain 3 (RFWD3) interaction partners

  1. a polymorphism in the 3'-UTR of RFWD3 had a strong association with PATN1, which affects spotting patterns in horse coat color

Human Ring Finger and WD Repeat Domain 3 (RFWD3) interaction partners

  1. RFWD3-dependent ubiquitination of RPA regulates repair at stalled replication forks.

  2. RFWD3 and RPA2 (show RPA2 Proteins) functionally interact and participate in replication checkpoint control

  3. RFWD3 is recruited to sites of DNA damage and facilitates RPA-mediated DNA damage signaling and repair

  4. Study identifies RFWD3 as a positive regulator of p53 (show TP53 Proteins) stability when the G(1) cell cycle checkpoint is activated and provides an explanation for how p53 (show TP53 Proteins) is protected from degradation in the presence of high levels of Mdm2 (show MDM2 Proteins).

RFWD3 Protein Profile

Protein Summary

E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair.

Gene names and symbols associated with RFWD3

  • ring finger and WD repeat domain 3 (Rfwd3)
  • ring finger and WD repeat domain 3 (RFWD3)
  • BC027246 protein
  • RFWD3 protein
  • RGD1305243 protein
  • RNF201 protein

Protein level used designations for RFWD3

ring finger and WD repeat domain 3 , RING finger and WD repeat domain-containing protein 3-like , E3 ubiquitin-protein ligase RFWD3 , RING finger and WD repeat domain-containing protein 3 , RING finger protein 201

GENE ID SPECIES
361409 Rattus norvegicus
415684 Gallus gallus
454242 Pan troglodytes
540072 Bos taurus
610424 Canis lupus familiaris
100055114 Equus caballus
100229473 Taeniopygia guttata
100387225 Callithrix jacchus
100461058 Pongo abelii
55159 Homo sapiens
234736 Mus musculus
Selected quality suppliers for RFWD3 Proteins (RFWD3)
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