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E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. Additionally we are shipping RFWD3 Proteins (3) and many more products for this protein.
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Human Polyclonal RFWD3 Primary Antibody for ELISA, WB - ABIN1535312
Matsuoka, Ballif, Smogorzewska, McDonald, Hurov, Luo, Bakalarski, Zhao, Solimini, Lerenthal, Shiloh, Gygi, Elledge: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. in Science (New York, N.Y.) 2007
a polymorphism in the 3'-UTR (show UTS2R Antibodies) of RFWD3 had a strong association with PATN1, which affects spotting patterns in horse coat color
RFWD3-dependent ubiquitination of RPA regulates repair at stalled replication forks.
RFWD3 and RPA2 (show RPA2 Antibodies) functionally interact and participate in replication checkpoint control
RFWD3 is recruited to sites of DNA damage and facilitates RPA-mediated DNA damage signaling and repair
Study identifies RFWD3 as a positive regulator of p53 (show TP53 Antibodies) stability when the G(1) cell cycle checkpoint is activated and provides an explanation for how p53 (show TP53 Antibodies) is protected from degradation in the presence of high levels of Mdm2 (show MDM2 Antibodies).
E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair.
ring finger and WD repeat domain 3
, RING finger and WD repeat domain-containing protein 3-like
, E3 ubiquitin-protein ligase RFWD3
, RING finger and WD repeat domain-containing protein 3
, RING finger protein 201