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Roundabout, Axon Guidance Receptor, Homolog 1 (Drosophila) Proteins (ROBO1)

Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Additionally we are shipping ROBO1 Antibodies (79) and ROBO1 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ROBO1 24906 O55006
ROBO1 19876 O89026
ROBO1 6091 Q9Y6N7
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Top ROBO1 Proteins at antibodies-online.com

Showing 7 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,530.00
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

ROBO1 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Mouse (Murine) ,
,
Human , , ,
, ,

More Proteins for Roundabout, Axon Guidance Receptor, Homolog 1 (Drosophila) (ROBO1) Interaction Partners

Zebrafish Roundabout, Axon Guidance Receptor, Homolog 1 (Drosophila) (ROBO1) interaction partners

  1. These results demonstrate a key role for Robo-Slit signaling in vertebrate longitudinal axon guidance; Robo1 and Robo3 (show ROBO3 Proteins) restricted the extent of defasciculation of the tract of the postoptic commissure.

Mouse (Murine) Roundabout, Axon Guidance Receptor, Homolog 1 (Drosophila) (ROBO1) interaction partners

  1. Robo1-Slit2 interaction required for pathfinding mechanism essential to establish the functionally important habenulo-interpeduncular connection.

  2. FLRT3 (show FLRT3 Proteins) is a Robo1 coreceptor in developing axons.

  3. Slit2 (show SLIT2 Proteins)/Robo1 signaling promotes intestinal tumorigenesis through Src (show SRC Proteins)-mediated activation of the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway.

  4. Robo1/2 regulate follicle atresia through manipulating granulosa cell apoptosis in mice

  5. Roundabout receptor (Robo) genes are expressed in pulmonary neuroendocrine cells (PNECs), a rare, innervated epithelial population. Robo inactivation in mouse lung results in an inability of PNECs to cluster into sensory organoids and triggers increased neuropeptide production upon exposure to air.

  6. Slit2 (show SLIT2 Proteins) signaling through Robo1 and Robo2 (show ROBO2 Proteins) has a role in retinal neovascularization

  7. Data indicate the roles of Slit1 (show SLIT1 Proteins)/Robo1 and Netrin1/DCC (show DCC Proteins) signals in positioning motor neuron cell bodies.

  8. This study demonistrated that significant increase of interneurons in the cortices of Robo1-/- mice, implicate Robo1 in the regulation of progenitor cell dynamics in the developing forebrain.

  9. we report that Robo1 plays an important role in guiding olfactory sensory neurons in the mouse olfactory system during development.

  10. SDF-1-CXCR4 differentially regulates autoimmune diabetogenic T cell adhesion through ROBO1-SLIT2 interactions in mice.

Human Roundabout, Axon Guidance Receptor, Homolog 1 (Drosophila) (ROBO1) interaction partners

  1. Significantly increased serum Slit2 (show SLIT3 Proteins) levels and hepatic expression of Slit2 (show SLIT3 Proteins) and Robo1 were observed in patients with liver fibrosis.

  2. our findings indicated that Slit2 (show SLIT3 Proteins)/Robo1 axis possibly be regarded as a significant clinical parameter for predicting brain metastasis in breast cancer patients.

  3. miR (show MLXIP Proteins)-29a markedly inhibits the protein expression of Robo1 in mesenchymal stem cells.

  4. A SLIT2 (show SLIT3 Proteins)/ROBO1 signaling circuit as a key regulatory mechanism.

  5. These results suggest that Slit2/Robo1 binding exerts an effect on cell migration, which is negatively regulated by Robo4, and Robo1 may function by interacting with CdGAP in HUVECs.

  6. ROBO1 somatic mutation is associated with myelodysplastic syndrome progression. Overexpression of ROBO1 produces anti-proliferative and pro-apoptotic effects in leukaemia cells. However, this effect was lost in ROBO mutants.

  7. Robo1 promoted cell division cycle 42 (Cdc42) expression in HUVECs, and a distorted actin cytoskeleton in HUVECs was observed when Robo1 expression was suppressed. In conclusion, Robo1 promoted angiogenesis in HCC (show FAM126A Proteins) mediated by Cdc42 (show CDC42 Proteins).

  8. Data indicate that SLIT2 (show SLIT3 Proteins), miR (show MLXIP Proteins)-218-1, RET (show RET Proteins)/PLAG1 (show PLAG1 Proteins) and SLIT2 (show SLIT3 Proteins)/ROBO1 pathway involved in Hirschsprung's disease.

  9. these studies demonstrate that miR (show MLXIP Proteins)-219-5p inhibited cancer cell growth and invasion by direct targeting ROBO1, implicating miR (show MLXIP Proteins)-219-5p as an attractive candidate for cancer therapy.

  10. Slit2 (show SLIT3 Proteins)/Robo1 signaling promotes intestinal tumorigenesis through Src (show SRC Proteins)-mediated activation of the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway.

ROBO1 Protein Profile

Protein Summary

Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with ROBO1

  • roundabout homolog 1 (robo1)
  • roundabout, axon guidance receptor, homolog 1 (Drosophila) (ROBO1)
  • roundabout, axon guidance receptor, homolog 1 (robo1)
  • roundabout, axon guidance receptor, homolog 1 (Drosophila) (robo1)
  • RoBo-1 (LOC24906)
  • roundabout homolog 1 (Drosophila) (Robo1)
  • roundabout, axon guidance receptor, homolog 1 (Drosophila) (Robo1)
  • AW494633 protein
  • AW742721 protein
  • DMT-1 protein
  • DUTT1 protein
  • Gm310 protein
  • MGC122264 protein
  • ROBO1 protein
  • roundabout protein
  • roundabout-1 protein
  • SAX3 protein

Protein level used designations for ROBO1

roundabout (axon guidance receptor, Drosophila) homolog 1 , roundabout, axon guidance receptor, homolog 1 (Drosophila) , Roundabout1 protein , roundabout-1 , roundabout 1 , roundabout homolog 1 , roundabout, axon guidance receptor, homolog 1 , roundabout homolog 1-like , divalent metal transporter-1 , protein RoBo-1 , rodent bone protein , deleted in U twenty twenty

GENE ID SPECIES
30769 Danio rerio
395292 Gallus gallus
399392 Xenopus laevis
460518 Pan troglodytes
536815 Bos taurus
722879 Macaca mulatta
100027473 Monodelphis domestica
100069075 Equus caballus
100124716 Xenopus (Silurana) tropicalis
100344245 Oryctolagus cuniculus
100387812 Callithrix jacchus
100459973 Pongo abelii
100517310 Sus scrofa
100545249 Meleagris gallopavo
100559253 Anolis carolinensis
100595092 Nomascus leucogenys
24906 Rattus norvegicus
19876 Mus musculus
6091 Homo sapiens
58946 Rattus norvegicus
487690 Canis lupus familiaris
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