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ROBO2 belongs to the ROBO family, part of the immunoglobulin superfamily proteins that are highly conserved from fly to human. Additionally we are shipping ROBO2 Proteins (9) and ROBO2 Kits (1) and many more products for this protein.
Showing 10 out of 72 products:
Chicken Polyclonal ROBO2 Primary Antibody for WB - ABIN2782202
Bertoli-Avella, Conte, Punzo, de Graaf, Lama, La Manna, Polito, Grassia, Nobili, Rambaldi, Oostra, Perrotta: ROBO2 gene variants are associated with familial vesicoureteral reflux. in Journal of the American Society of Nephrology : JASN 2008
Human Polyclonal ROBO2 Primary Antibody for ELISA, WB - ABIN334482
Fujisawa, Wrana, Culotti: The slit receptor EVA-1 coactivates a SAX-3/Robo mediated guidance signal in C. elegans. in Science (New York, N.Y.) 2007
Human Polyclonal ROBO2 Primary Antibody for IHC, ELISA - ABIN1535320
Kidd, Brose, Mitchell, Fetter, Tessier-Lavigne, Goodman, Tear: Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors. in Cell 1998
Genetic analysis showed that Caspase-3 (show CASP3 Antibodies), Caspase-9 (show CASP9 Antibodies), and p38 MAPK (show MAPK14 Antibodies) interacted with Slit1a-Robo2 signaling.
The N-terminal domain unique to Robo3a (show ROBO3 Antibodies).1 mediates blockade of Robo2 repulsive activity.
Robo2-Slit and Dcc (show DCC Antibodies)-Netrin1 coordinate the axonal projection choices of neurons developing in the forebrain.
These results reveal that subtype-specific activity of Robo2 regulates subcircuit morphogenesis in the trigeminal sensory system.
Increased arborization in robo2 mutants was phenocopied by dominant-negative Robo2 expressed in single retinal ganglion cells and rescued by full-length Robo2, indicating that Robo2 acts cell-autonomously.
Robo2 acted initially to split the tract of the postoptic commissure into discrete fascicles upon entering a broad domain of Slit1a expression in the ventrocaudal diencephalon.
Robo1 (show ROBO1 Antibodies)/2 regulate follicle atresia through manipulating granulosa cell apoptosis in mice
Roundabout receptor (Robo) genes are expressed in pulmonary neuroendocrine cells (PNECs), a rare, innervated epithelial population. Robo inactivation in mouse lung results in an inability of PNECs to cluster into sensory organoids and triggers increased neuropeptide production upon exposure to air.
Loss of Robo2 resulted in a failure of the normal separation of the mesenchyme from the Wolffian duct/ureteric epithelium.
Mutations of the SLIT2 (show SLIT2 Antibodies)-ROBO2 pathway genes SLIT2 (show SLIT2 Antibodies) and SRGAP1 (show SRGAP1 Antibodies) confer risk for congenital anomalies of the kidney and urinary tract
Slit2 (show SLIT2 Antibodies) signaling through Robo1 (show ROBO1 Antibodies) and Robo2 has a role in retinal neovascularization
Mycbp2 (show MYCBP2 Antibodies) and Robo2 were found to cooperate within a genetic network that has profound effects on axon guidance
Report role of Robo2 in development of the caval veins and pericardium.
Inactivation of Robo 2 leads to mispositioning of the stomach in the thoracic instead of the abdominal cavity, which likely contributes to poor lung inflation and lethality at birth, reminiscent of congenital diaphragmatic hernia.
Robo2 signaling acts as a negative regulator on nephrin (show NPHS1 Antibodies) to influence podocyte foot process architecture.
Gbx2 (show GBX2 Antibodies) regulates thalamocortical axon guidance by modifying the LIM (show PDLIM5 Antibodies) and Robo codes.
Overexpression of ROBO2 induces its tumor suppressive effects in Breast cancer
ROBO2 somatic mutation is associated with myelodysplastic syndrome progression. Overexpression of ROBO2 produces anti-proliferative and pro-apoptotic effects in leukemia cells. This effect was lost in ROBO mutants and ROBO-SLIT2 signaling is impaired.
Common variation near ROBO2 is associated with expressive vocabulary in infancy.
Mutations of the SLIT2 (show SLIT3 Antibodies)-ROBO2 pathway genes SLIT2 (show SLIT3 Antibodies) and SRGAP1 (show SRGAP1 Antibodies) confer risk for congenital anomalies of the kidney and urinary tract
Down-regulation of ROBO2 expression is associated with prostate cancers.
Frameshift mutations of ROBO1 (show ROBO1 Antibodies) and ROBO2 genes and alteration of ROBO2 expression in gastric and colorectal cancers suggest that both genes might play roles in the pathogenesis of both cancers.
The finding that a polymorphism associated with the ROBO2 gene, which is involved in neurodevelopment, confers risk for the common emotionally reactive, impulsive aspects of conduct disorder, independent of concurrent risk for psychopathy.
Results not completely rule out that some ROBO2 variants may be the sole cause of vesicoureteric reflux, but it is clear from the overall frequency that most of them cannot be.
data suggests the importance of abrogation of SLIT2 (show SLIT3 Antibodies)-ROBO1 (show ROBO1 Antibodies) and SLIT2 (show SLIT3 Antibodies)-ROBO2 interactions in the initiation and progression of CACX and also for early diagnosis and prognosis of the disease
Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux.
This gene belongs to the ROBO family, part of the immunoglobulin superfamily proteins that are highly conserved from fly to human. The encoded protein is a receptor for SLIT2, molecules known to function in axon guidance and cell migration. Defects in this gene are the cause of vesicoureteral reflux type 2. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
roundabout, axon guidance receptor, homolog 2 (Drosophila)
, roundabout homolog 2-like
, roundabout homolog 2
, roundabout, axon guidance receptor, homolog 2
, Robo 2
, roundabout 2 precursor
, Roundabout2 protein