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Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. Additionally we are shipping ROBO4 Proteins (7) and ROBO4 Kits (4) and many more products for this protein.
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Human Polyclonal ROBO4 Primary Antibody for ELISA - ABIN1999429
Huminiecki, Gorn, Suchting, Poulsom, Bicknell: Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis. in Genomics 2002
Show all 2 references for ABIN1999429
Sox7 (show SOX7 Antibodies) and Sox18 (show SOX18 Antibodies)-mediated transcriptional regulation of Robo4 is important in the developing embryonic vasculature
robo4 is essential for coordinated symmetric and directed sprouting of intersomitic vessels.
Robo4 mediates attraction-signaling mechanisms through Rho GTPases in vertebrate vascular guidance
endothelial Robo4 signaling is important for suppressing breast cancer growth and metastasis, and it can be targeted (enhanced) by administrating a small molecular drug.
Robo4 vaccines induce antibodies that retard tumor growth.
Robo4 and Src family kinases are involved in the mechanisms of embryonic vascular defects caused by the Hrt/Hey deficiency.
These results clearly indicate that Robo4 plays a role in hematopoietic stem cells trafficking such as bone marrow homing and peripheral mobilization.
our results showed an important role of Robo4 in the regulation of cortical radial migration through Slit-dependent and -independent mechanisms
Data found that expression of Slit2 (show SLIT2 Antibodies) and SDF1 (show CXCL12 Antibodies) were dynamically regulated in mesenchymal stem cells and OBC-like populations following radiation, while Robo4 expression was restricted to endothelial cells.
augmenting the host Robo4/Slit2 system could provide a useful therapeutic approach to control pathological angiogenesis associated with HSV induced stromal keratitis
Robo4 specifically binds to UNC5B (show UNC5B Antibodies), a vascular Netrin receptor, revealing unexpected interactions between two endothelial guidance receptors.
Activating with the soluble ligand Slit an endothelium-specific, Robo4-dependent signaling pathway that strengthens the vascular barrier, diminishing deleterious aspects of the host's response to the pathogen-induced cytokine storm.
enhanced growth of blood vessels in Robo4(-/-) endothelium is due to activation of vascular endothelial growth factor (VEGF)-R2 signaling through the Src and FAK kinases.
there was a increase in Robo4 expression under hyperglycemic conditions, while there was a decrease under hypoxic and combined hypoxic and hyperglycemic conditions, suggesting Robo4 might play different roles in various stages of diabetic retinopathy
These results suggest that Slit2 (show SLIT3 Antibodies)/Robo1 (show ROBO1 Antibodies) binding exerts an effect on cell migration, which is negatively regulated by Robo4, and Robo1 (show ROBO1 Antibodies) may function by interacting with CdGAP (show ARHGAP31 Antibodies) in HUVECs.
results indicate that AP-1 (show FOSB Antibodies) complexes regulate Robo4 gene expression in endothelial cells
BM Robo4 expression can serve as a new biomarker to predict clinical outcomes in AML (show RUNX1 Antibodies) patients and Robo4 may serve as a potential therapeutic target in patients with higher Robo4 expression.
Robo4 suppressed glioma-induced endothelial cell proliferation, migration and tube formation in vitro by inhibiting VEGR2-mediated activation of PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) and FAK (show PTK2 Antibodies) signaling pathways.
Increased or decreased expression of Robo4 by stimulation or knockdown of HIF-1alpha (show HIF1A Antibodies) suggesting that Robo4 is positively regulated by HIF-1alpha (show HIF1A Antibodies) under normoxic and hypoxic conditions in microvascular endothelial cells in vitro.
Plasma Robo4 levels are increased, transiently, following cardiac surgery requiring CPB (show CPB1 Antibodies)
This study demonistrated that roundabout (show ROBO1 Antibodies) 4 regulates blood-tumor barrier permeability through the modulation of ZO-1 (show TJP1 Antibodies), Occludin (show OCLN Antibodies), and Claudin-5 (show CLDN5 Antibodies) expression.
Endothelial cell-specific DNA methylation (show HELLS Antibodies) pattern of the Robo4 proximal promoter is determined during cell differentiation and contributes to regulation of EC-specific Robo4 gene expression.
SLIT3 (show SLIT1 Antibodies)-ROBO4 activation promotes vascular network formation in human engineered tissue and angiogenesis in vivo.
Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity).
roundabout homolog 4
, magic roundabout
, Magic roundabout
, roundabout homolog 4, magic roundabout