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Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila) Proteins (ROBO4)

Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. Additionally we are shipping ROBO4 Antibodies (52) and ROBO4 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ROBO4 74144 Q8C310
ROBO4 54538 Q8WZ75
Rat ROBO4 ROBO4 300518 Q80W87
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Top ROBO4 Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag 100 μg Log in to see 2 to 3 Days
$275.00
Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Mouse His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Human Human Fc Tag   10 μg Log in to see 5 Days
$143.00
Details
HOST_HEK-293 Human His tag   0.1 mg Log in to see 2 to 3 Days
$515.63
Details

ROBO4 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Human , , , ,
,

Top referenced ROBO4 Proteins

  1. Human ROBO4 Protein expressed in HEK-293 Cells - ABIN2181695 : Huminiecki, Gorn, Suchting, Poulsom, Bicknell: Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis. in Genomics 2002 (PubMed)
    Show all 2 references for ABIN2181695

  2. Human ROBO4 Protein expressed in Human Cells - ABIN2004922 : Koch, Mathivet, Larrivée, Tong, Kowalski, Pibouin-Fragner, Bouvrée, Stawicki, Nicholes, Rathore, Scales, Luis, del Toro, Freitas, Bréant, Michaud, Corvol, Thomas, Wu, Peale, Watts, Tessier-Lavigne et al.: Robo4 maintains vessel integrity and inhibits angiogenesis by interacting with UNC5B. ... in Developmental cell 2011 (PubMed)
    Show all 2 references for ABIN2004922

More Proteins for Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila) (ROBO4) Interaction Partners

Zebrafish Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila) (ROBO4) interaction partners

  1. Sox7 (show SOX7 Proteins) and Sox18 (show SOX18 Proteins)-mediated transcriptional regulation of Robo4 is important in the developing embryonic vasculature

  2. robo4 is essential for coordinated symmetric and directed sprouting of intersomitic vessels.

  3. Robo4 mediates attraction-signaling mechanisms through Rho GTPases in vertebrate vascular guidance

Mouse (Murine) Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila) (ROBO4) interaction partners

  1. endothelial Robo4 signaling is important for suppressing breast cancer growth and metastasis, and it can be targeted (enhanced) by administrating a small molecular drug.

  2. Robo4 vaccines induce antibodies that retard tumor growth.

  3. Robo4 and Src family kinases are involved in the mechanisms of embryonic vascular defects caused by the Hrt/Hey deficiency.

  4. These results clearly indicate that Robo4 plays a role in hematopoietic stem cells trafficking such as bone marrow homing and peripheral mobilization.

  5. our results showed an important role of Robo4 in the regulation of cortical radial migration through Slit-dependent and -independent mechanisms

  6. Data found that expression of Slit2 (show SLIT2 Proteins) and SDF1 (show CXCL12 Proteins) were dynamically regulated in mesenchymal stem cells and OBC-like populations following radiation, while Robo4 expression was restricted to endothelial cells.

  7. augmenting the host Robo4/Slit2 system could provide a useful therapeutic approach to control pathological angiogenesis associated with HSV induced stromal keratitis

  8. Robo4 specifically binds to UNC5B (show UNC5B Proteins), a vascular Netrin receptor, revealing unexpected interactions between two endothelial guidance receptors.

  9. Activating with the soluble ligand Slit an endothelium-specific, Robo4-dependent signaling pathway that strengthens the vascular barrier, diminishing deleterious aspects of the host's response to the pathogen-induced cytokine storm.

  10. enhanced growth of blood vessels in Robo4(-/-) endothelium is due to activation of vascular endothelial growth factor (VEGF)-R2 signaling through the Src and FAK kinases.

Human Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila) (ROBO4) interaction partners

  1. there was a increase in Robo4 expression under hyperglycemic conditions, while there was a decrease under hypoxic and combined hypoxic and hyperglycemic conditions, suggesting Robo4 might play different roles in various stages of diabetic retinopathy

  2. These results suggest that Slit2/Robo1 binding exerts an effect on cell migration, which is negatively regulated by Robo4, and Robo1 may function by interacting with CdGAP in HUVECs.

  3. results indicate that AP-1 (show FOSB Proteins) complexes regulate Robo4 gene expression in endothelial cells

  4. BM Robo4 expression can serve as a new biomarker to predict clinical outcomes in AML (show RUNX1 Proteins) patients and Robo4 may serve as a potential therapeutic target in patients with higher Robo4 expression.

  5. Robo4 suppressed glioma-induced endothelial cell proliferation, migration and tube formation in vitro by inhibiting VEGR2-mediated activation of PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) and FAK (show PTK2 Proteins) signaling pathways.

  6. Increased or decreased expression of Robo4 by stimulation or knockdown of HIF-1alpha (show HIF1A Proteins) suggesting that Robo4 is positively regulated by HIF-1alpha (show HIF1A Proteins) under normoxic and hypoxic conditions in microvascular endothelial cells in vitro.

  7. Plasma Robo4 levels are increased, transiently, following cardiac surgery requiring CPB (show CPB1 Proteins)

  8. This study demonistrated that roundabout (show ROBO1 Proteins) 4 regulates blood-tumor barrier permeability through the modulation of ZO-1 (show TJP1 Proteins), Occludin (show OCLN Proteins), and Claudin-5 (show CLDN5 Proteins) expression.

  9. Endothelial cell-specific DNA methylation (show HELLS Proteins) pattern of the Robo4 proximal promoter is determined during cell differentiation and contributes to regulation of EC-specific Robo4 gene expression.

  10. SLIT3 (show SLIT1 Proteins)-ROBO4 activation promotes vascular network formation in human engineered tissue and angiogenesis in vivo.

ROBO4 Protein Profile

Protein Summary

Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity).

Gene names and symbols associated with ROBO4

  • roundabout homolog 4 (robo4)
  • roundabout homolog 4 (Drosophila) (Robo4)
  • roundabout homolog 4, magic roundabout (Drosophila) (ROBO4)
  • roundabout, axon guidance receptor, homolog 4 (Drosophila) (ROBO4)
  • roundabout, axon guidance receptor, homolog 4 (Drosophila) (Robo4)
  • 1200012D01Rik protein
  • AI593217 protein
  • ECSM4 protein
  • MRB protein
  • sc:d0823 protein
  • wu:fa16f09 protein

Protein level used designations for ROBO4

roundabout homolog 4 , magic roundabout , Magic roundabout , roundabout homolog 4, magic roundabout

GENE ID SPECIES
259253 Danio rerio
560765 Danio rerio
74144 Mus musculus
783785 Bos taurus
54538 Homo sapiens
489306 Canis lupus familiaris
100524821 Sus scrofa
300518 Rattus norvegicus
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