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RUNX2 is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. Additionally we are shipping RUNX2 Kits (49) and RUNX2 Proteins (12) and many more products for this protein.
Showing 10 out of 230 products:
Human Polyclonal RUNX2 Primary Antibody for DB - ABIN389942
McNamara, Sjöström, Burgess, Kim, Liu, Gordonov, Moghe, Meek, Oreffo, Su, Dalby: Skeletal stem cell physiology on functionally distinct titania nanotopographies. in Biomaterials 2011
Show all 8 references for ABIN389942
Human Polyclonal RUNX2 Primary Antibody for EIA - ABIN358487
Ermakov, Malkin, Keter, Kobyliansky, Livshits: Family-based association study of polymorphisms in the RUNX2 locus with hand bone length and hand BMD. in Annals of human genetics 2008
Show all 3 references for ABIN358487
Human Polyclonal RUNX2 Primary Antibody for WB - ABIN2780588
Lee, Lee, Ryoo, Park, Park, Bae, Cho, Park: The odontogenic ameloblast-associated protein (ODAM) cooperates with RUNX2 and modulates enamel mineralization via regulation of MMP-20. in Journal of cellular biochemistry 2010
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Human Polyclonal RUNX2 Primary Antibody for EIA, WB - ABIN360019
Rich, Rosová, Nolta, Myckatyn, Sandell, McAlinden: Upregulation of Runx2 and Osterix during in vitro chondrogenesis of human adipose-derived stromal cells. in Biochemical and biophysical research communications 2008
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Cow (Bovine) Polyclonal RUNX2 Primary Antibody for WB - ABIN2774905
Guo, Chung, Yang, Karsenty, Bringhurst, Kronenberg: PTH/PTHrP receptor delays chondrocyte hypertrophy via both Runx2-dependent and -independent pathways. in Developmental biology 2006
Show all 2 references for ABIN2774905
Chicken Polyclonal RUNX2 Primary Antibody for WB - ABIN2774906
Ducy, Zhang, Geoffroy, Ridall, Karsenty: Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. in Cell 1997
Runx2 may have an evolutionarily conserved role in axis formation
our studies reveal a novel function for Runx2 in regulating mammary epithelial cell regenerative potential, possibly acting as a downstream target of WNT (show WNT2 Antibodies) signalling.
MED23 (show MED23 Antibodies) binds to RUNX2 and modulates its transcriptional activity.
Hand1 (show HAND1 Antibodies) downregulated Ihh (show IHH Antibodies) gene expression in vitro by inhibiting Runx2 transactivation of the Ihh (show IHH Antibodies) proximal promoter.
increased intranuclear actin forces MSC (show MSC Antibodies) into osteogenic lineage through controlling Runx2 activity; this process may be useful for clinical objectives of forming bone.
We observed that tranilast increased mRNA expression of both Sox9 (show SOX9 Antibodies) and Runx2 in differentiating ATDC5 chondrogenic progenitor cells.
Results propose that Utx (show KDM6A Antibodies) plays important roles in osteoblast differentiation by controlling the expressions of Runx2 and Osterix (show SP7 Antibodies).
Somatic transmission of Runx2 mRNAs in osteoblasts and osteosarcoma cells represents a versatile mechanism for translational rather than transcriptional induction.
The data indicate a critical role of Runx2 in Smooth muscle cell (SMC (show DYM Antibodies)) osteogenic phenotype change and mineral deposition in a mouse model of Arterial medial calcification (AMC).
Gene expression of Tau, a neuronal phosphoprotein with important roles in neuronal biology and microtubule dynamics and assembly, was high in wild-type molars but severely reduced in transgenic(Col1a1 (show COL1A1 Antibodies)-Runx2) molars.
Runx2/miR (show MLXIP Antibodies)-3960/miR (show MLXIP Antibodies)-2861 positive feedback loop plays an important role in osteogenic transdifferentiation of vascular smooth muscle cells and contributes to vascular calcification.
Preameloblast-Derived Factors Mediate Osteoblast Differentiation of Human Bone Marrow Mesenchymal Stem Cells by Runx2-Osterix (show SP7 Antibodies)-BSP (show KLK6 Antibodies) Signaling.
Runx2 activation by BMP signaling mediates serum deprivation triggers upregulation of hST3Gal V gene expression in MG-63 cells.
GnRH (show GNRH1 Antibodies) regulates trophoblast invasion via RUNX2-mediated MMP2 (show MMP2 Antibodies)/MMP9 (show MMP9 Antibodies) expression.
An osteogenic medium is required for the differentiation of adul tmesenchymal stem cells, which is also under RUNX2 regulation. These findings are potentially valuable for clinical practice.
This integrative genomic study confirmed the role of RUNX2 as a potential driver of AS and identified a new AS susceptibility gene, CACNA1C (show CACNA1C Antibodies), belonging to the calcium signaling pathway.
It is suggested that oxytalan-positive POFs, purportedly originating from the periodontal ligament, express molecules that are specific to bone and cementum (Runx-2, BMP-2 (show BMP2 Antibodies)), or cementum only (CAP).
results reveal the regulatory circuit between RUNX2 and SMURF1 (show SMURF1 Antibodies) controls RUNX2 expression and regulates odntoblastic differentiation in hDPSCs.
Data suggest that RUNX2 transcription factor:TAZ transcriptional co-activator and activation of sE-Cadherin/proto-oncogene (show RAB1A Antibodies) protein HER-2 (show ERBB2 Antibodies) signaling could be potential oncogenic pathways for breast cancer (BC) metastasis.
RUNX2 mediates epigenetic regulation of the survival of p53 (show TP53 Antibodies) defective osteosarcoma cells.
Studies indicate the involvement of estrogen signaling in breast cancer development and the interaction between RUNX2 and estrogen-dependent pathways can contribute to the mechanisms involved in cancer transformation. [review]
The OPG (show TNFSF11 Antibodies) expression levels decreased while those of RANKL (show TNFSF11 Antibodies) and RUNX2 increased during orthodontic tooth movement, which suggested that they play a role in the osteogenesis process and the reconstruction of periodontal tissue.
These data also indicate that MGP (show MGP Antibodies) is under dual regulation by runx2 through the use of various isoforms and context-dependent formation of transcriptional complexes.
This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.
runt-related transcription factor 2
, transcription factor Runx2a
, transcription factor Cbfa1
, runt-related transcription factor 2-like
, AKV core binding factor
, PEA2-alpha A
, PEBP2 alpha A
, SL3-3 enhancer factor 1 alpha A subunit
, acute myeloid leukemia 3 protein
, core binding factor alpha 1
, osteoblast-specific transcription factor 2
, polyomavirus enhancer-binding protein 2 alpha A subunit
, runt domain, alpha subunit 1
, PEBP2-alpha A
, SL3/AKV core-binding factor alpha A subunit
, core-binding factor, runt domain, alpha subunit 1
, oncogene AML-3
, runt-related factor 2
, core-binding factor subunit alpha-1
, runt related transcription factor 2
, Runx2 spliced isoform
, runt-related transcription factor 2 type I
, runt-related transcription factor 2 type II
, core binding factor alpha 1 subunit