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RUNX2 is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. Additionally we are shipping RUNX2 Kits (38) and RUNX2 Proteins (12) and many more products for this protein.
Showing 10 out of 238 products:
Human Polyclonal RUNX2 Primary Antibody for DB - ABIN389942
McNamara, Sjöström, Burgess, Kim, Liu, Gordonov, Moghe, Meek, Oreffo, Su, Dalby: Skeletal stem cell physiology on functionally distinct titania nanotopographies. in Biomaterials 2011
Show all 8 references for ABIN389942
Human Polyclonal RUNX2 Primary Antibody for EIA - ABIN358487
Ermakov, Malkin, Keter, Kobyliansky, Livshits: Family-based association study of polymorphisms in the RUNX2 locus with hand bone length and hand BMD. in Annals of human genetics 2008
Show all 3 references for ABIN358487
Human Polyclonal RUNX2 Primary Antibody for WB - ABIN2780588
Lee, Lee, Ryoo, Park, Park, Bae, Cho, Park: The odontogenic ameloblast-associated protein (ODAM) cooperates with RUNX2 and modulates enamel mineralization via regulation of MMP-20. in Journal of cellular biochemistry 2010
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Human Polyclonal RUNX2 Primary Antibody for EIA, WB - ABIN360019
Rich, Rosová, Nolta, Myckatyn, Sandell, McAlinden: Upregulation of Runx2 and Osterix during in vitro chondrogenesis of human adipose-derived stromal cells. in Biochemical and biophysical research communications 2008
Show all 2 references for ABIN360019
Cow (Bovine) Polyclonal RUNX2 Primary Antibody for WB - ABIN2774905
Guo, Chung, Yang, Karsenty, Bringhurst, Kronenberg: PTH/PTHrP receptor delays chondrocyte hypertrophy via both Runx2-dependent and -independent pathways. in Developmental biology 2006
Show all 2 references for ABIN2774905
Chicken Polyclonal RUNX2 Primary Antibody for WB - ABIN2774906
Ducy, Zhang, Geoffroy, Ridall, Karsenty: Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. in Cell 1997
Runx2 may have an evolutionarily conserved role in axis formation
in murine bone marrow stromal cells undergoing osteogenic differentiation, TNF-alpha (show TNF Antibodies) and it activated NF-kappaB (show NFKB1 Antibodies) pathway inhibit the expression of Runx2 gene, and suppress the Runx2-mediated osteogenic gene transcription via the 9.0 kb BSP (show KLK6 Antibodies) promoter.
results suggest that 1,25(OH)D induces the transdifferentiation of osteoblasts to adipocytes via Runx2 downregulation in osteoblasts.
In a model of instability-induced osteoarthritis, Runx2 was overexpressed in articular chondrocytes and osteophyte-forming cells in LOX-1 (show OLR1 Antibodies)(+)/(+) mice and was significantly downregulated in articular chondrocytes and osteophyte-forming cells in LOX-1 (show OLR1 Antibodies)(-)/(-) mice.
miR23b inhibits BMP9induced C2C12 myoblast osteogenesis via targeting of the Runx2 gene, acting as a suppressor.
Runx2-modified adipose-derived stem cells promote tendon graft integration in anterior cruciate ligament reconstruction.
FHL2 (show FHL2 Antibodies) might interact with Runx2 to mediate mesenchymal cell differentiation at the early stages of tooth development and human dental pulp cell differentiation.
our studies reveal a novel function for Runx2 in regulating mammary epithelial cell regenerative potential, possibly acting as a downstream target of WNT (show WNT2 Antibodies) signalling.
MED23 (show MED23 Antibodies) binds to RUNX2 and modulates its transcriptional activity.
Hand1 (show HAND1 Antibodies) downregulated Ihh (show IHH Antibodies) gene expression in vitro by inhibiting Runx2 transactivation of the Ihh (show IHH Antibodies) proximal promoter.
increased intranuclear actin forces MSC (show MSC Antibodies) into osteogenic lineage through controlling Runx2 activity; this process may be useful for clinical objectives of forming bone.
Findings suggest thatSirt1 may regulate the expression of Runx2, which is the osteogenic transcription factor, and the production of MMP-13 (show MMP13 Antibodies) from chondrocytes in OA.
Runx2 is a direct downstream target of miR (show MLXIP Antibodies)-455 in hepatocellular carcinoma.
The predictability of Runx2 for OS in stage IV tumours differs with different ER states.
the findings of this study provide evidence of the upregulation of miR628-3p in patients with atrophic non-union and that miR628-3p may exert an inhibitory effect on osteogenesis via the suppression of its target gene, RUNX2.
miR (show MLXIP Antibodies)-205 acts as a tumor suppressor in human osteosarcoma via directly targeting RUNX2.
BMP2 (show BMP2 Antibodies) and RUNX2 are expressed exclusively by osteoblasts whereas DSPP (show DSPP Antibodies) and LOXL2 (show LOXL2 Antibodies) are expressed exclusively by odontoblasts. (Review)
Study identified a sporadic CCD patient carrying a novel insertion/frameshift mutation of RUNX2.
our results reveal that RUNX2 promotes hepatocellular carcinoma (HCC (show FAM126A Antibodies)) cell migration and invasion by MMP9 (show MMP9 Antibodies)-mediated pathway, and potentially serves as a new prognostic biomarker and in therapeutic strategies for HCC (show FAM126A Antibodies).
Therefore, RUNX2 haploinsufficiency impairs dental follicle-induced osteoclast formation capacity through RANKL/OPG (show TNFSF11 Antibodies) signaling, which may be partially responsible for delayed permanent tooth eruption in cleidocranial dysplasia patients.
downregulation of miR (show MLXIP Antibodies)-218 may contribute to the chemoresistance of non-small cell lung cancer cells to cisplatin, which leads to upregulation of RUNX2
The OPG (show TNFSF11 Antibodies) expression levels decreased while those of RANKL (show TNFSF11 Antibodies) and RUNX2 increased during orthodontic tooth movement, which suggested that they play a role in the osteogenesis process and the reconstruction of periodontal tissue.
These data also indicate that MGP (show MGP Antibodies) is under dual regulation by runx2 through the use of various isoforms and context-dependent formation of transcriptional complexes.
This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.
runt-related transcription factor 2
, transcription factor Runx2a
, transcription factor Cbfa1
, runt-related transcription factor 2-like
, AKV core binding factor
, PEA2-alpha A
, PEBP2 alpha A
, SL3-3 enhancer factor 1 alpha A subunit
, acute myeloid leukemia 3 protein
, core binding factor alpha 1
, osteoblast-specific transcription factor 2
, polyomavirus enhancer-binding protein 2 alpha A subunit
, runt domain, alpha subunit 1
, PEBP2-alpha A
, SL3/AKV core-binding factor alpha A subunit
, core-binding factor, runt domain, alpha subunit 1
, oncogene AML-3
, runt-related factor 2
, core-binding factor subunit alpha-1
, runt related transcription factor 2
, Runx2 spliced isoform
, runt-related transcription factor 2 type I
, runt-related transcription factor 2 type II
, core binding factor alpha 1 subunit