anti-Runt-Related Transcription Factor 1 (RUNX1) Antibodies

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. Additionally we are shipping RUNX1 Kits (14) and RUNX1 Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RUNX1 12394 Q03347
RUNX1 861 Q01196
RUNX1 50662 Q63046
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-RUNX1 Antibodies at antibodies-online.com

Showing 10 out of 284 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB Sample Type : Mouse, post-natal day (p) 0 retinal ganglion cells Primary Antibody Dilution : 1:1500 Secondary Antibody : Donkey anti rabbit IgG Alexa 594 Secondary Antibody Dilution : 1:1000 Gene Name : RUNX1  Submitted by : Anonymous WB Suggested Anti-RUNX1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:12500 Positive Control: PANC1 cell lysate There is BioGPS gene expression data showing that RUNX1 is expressed in PANC1 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-RUNX1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:12500<br><b>Positive Control: </b>Jurkat cell lysate WB Suggested Anti-RUNX1 <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:12500 <br /> Positive Control: Jurkat cell lysate <br /> RUNX1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-RUNX1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>Jurkat cell lysate WB Suggested Anti-RUNX1 <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500 <br /> Positive Control: Jurkat cell lysate <br /> RUNX1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-RUNX1/AML1 Picoband antibody ,  All lanes: Anti RUNX1  at 0.5ug/ml WB: Recombinant Human RUNX1 Protein 0.5ng Predicted bind size: 50KD Observed bind size: 50KD Anti-RUNX1/AML1 Picoband antibody ,  IHC(P): Mouse Intestine Tissue 100 μg Log in to see 4 to 6 Days
$240.00
Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-RUNX1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:12500<br><b>Positive Control: </b>PANC1 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB <b>WB Suggested Anti-RUNX1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:1562500<br><b>Positive Control: </b>SH-SYSY cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-RUNX1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>721_B cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HepG2 cells treated with PMA 125ng/ml 30', using AML1 (Phospho-Ser435) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of RUNX1-S276 (ABIN650732) in K562 cell line lysates (35 µg/lane). RUNX1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with RUNX1 Antibody (S276) (ABIN650732), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HepG2 cells, treated with PMA 125ng/ml 30', using AML1 (Ab-435) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details

RUNX1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) , ,
, ,
,
, , , , , , , , , , , , ,
Human , , , ,
, , ,
,
, , , , , , , , , , , , , , , ,
Rat (Rattus) , ,
,

, , , , , , , , , , , , ,

Top referenced anti-RUNX1 Antibodies

  1. Human Polyclonal RUNX1 Primary Antibody for WB - ABIN2668716 : Zaidi, Dowdy, van Wijnen, Lian, Raza, Stein, Croce, Stein: Altered Runx1 subnuclear targeting enhances myeloid cell proliferation and blocks differentiation by activating a miR-24/MKP-7/MAPK network. in Cancer research 2009 (PubMed)
    Show all 19 Pubmed References

  2. Human Monoclonal RUNX1 Primary Antibody for IF, IHC (p) - ABIN514054 : Hussein, Dralle, Theophile, Kreipe, Bock: Megakaryocytic expression of miRNA 10a, 17-5p, 20a and 126 in Philadelphia chromosome-negative myeloproliferative neoplasm. in Annals of hematology 2009 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal RUNX1 Primary Antibody for WB - ABIN537342 : Srivastava, Srivastava: Expression of mRNA and proteins for toll-like receptors, associated molecules, defensins and LL-37 by SRIK-NKL, a CD8+ NK/T cell line. in Leukemia research 2005 (PubMed)
    Show all 2 Pubmed References

  4. Human Monoclonal RUNX1 Primary Antibody for ELISA, WB - ABIN969390 : Marshall, Moore, Ohki, Kitabayashi, Patterson, Ornelles: RUNX1 permits E4orf6-directed nuclear localization of the adenovirus E1B-55K protein and associates with centers of viral DNA and RNA synthesis. in Journal of virology 2008 (PubMed)
    Show all 2 Pubmed References

  5. Human Polyclonal RUNX1 Primary Antibody for WB - ABIN2801939 : Miyoshi, Shimizu, Kozu, Maseki, Kaneko, Ohki: t(8,21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1. in Proceedings of the National Academy of Sciences of the United States of America 1992 (PubMed)
    Show all 4 Pubmed References

  6. Human Monoclonal RUNX1 Primary Antibody for IF, IHC (p) - ABIN2476393 : Tsou, Ransom, Gerlt, Powers, Kenyon: Selection and characterization of a mutant of the cloned gene for mandelate racemase that confers resistance to an affinity label by greatly enhanced production of enzyme. in Biochemistry 1989 (PubMed)
    Show all 2 Pubmed References

  7. Human Polyclonal RUNX1 Primary Antibody for ICC, IF - ABIN4351429 : Ferrari, Mohammed, Nixon, Mason, Mallon, McMillan, Morris, Cameron, Edwards, Blyth: Expression of RUNX1 correlates with poor patient prognosis in triple negative breast cancer. in PLoS ONE 2014 (PubMed)

  8. Human Monoclonal RUNX1 Primary Antibody for IF, IHC (p) - ABIN514053 : Keita, Bachvarova, Morin, Plante, Gregoire, Renaud, Sebastianelli, Trinh, Bachvarov: The RUNX1 transcription factor is expressed in serous epithelial ovarian carcinoma and contributes to cell proliferation, migration and invasion. in Cell cycle (Georgetown, Tex.) 2013 (PubMed)

  9. Human Monoclonal RUNX1 Primary Antibody for ICC, ELISA - ABIN969389 : Zharlyganova, Harada, Harada, Shinkarev, Zhumadilov, Zhunusova, Tchaizhunusova, Apsalikov, Kemaikin, Zhumadilov, Kawano, Kimura, Hoshi: High frequency of AML1/RUNX1 point mutations in radiation-associated myelodysplastic syndrome around Semipalatinsk nuclear test site. in Journal of radiation research 2008 (PubMed)

  10. Human Monoclonal RUNX1 Primary Antibody for ELISA, WB - ABIN966980 : Ichikawa, Goyama, Asai, Kawazu, Nakagawa, Takeshita, Chiba, Ogawa, Kurokawa: AML1/Runx1 negatively regulates quiescent hematopoietic stem cells in adult hematopoiesis. in Journal of immunology (Baltimore, Md. : 1950) 2008 (PubMed)
    Show all 2 Pubmed References

More Antibodies against RUNX1 Interaction Partners

Mouse (Murine) Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. RUNX1 is essential for the development of the granular convoluted tubules in the submandibular glands; RUNX1 could also be involved in the membrane trafficking of the AQP5 (show AQP5 Antibodies) protein of the acinar cells in the SMG (show SNRPG Antibodies) in order to allow for the proper secretion of saliva (show RAG1AP1 Antibodies)

  2. High RUNX1 expression is associated with skin squamous cell carcinoma.

  3. deficiency alters the expression of a crucial subset of TAL1 (show TAL1 Antibodies)- and NOTCH1 (show NOTCH1 Antibodies)-regulated genes, including the MYB (show MYB Antibodies) and MYC (show MYC Antibodies) oncogenes, respectively.

  4. results demonstrate that RUNX1, when uncoupled from the requirement for cooperative ETS1 binding, is sufficient to drive long-range loop formation by the enhancer Ebeta, nucleosome clearance at its target promoters, and full transcriptional activation of the TCR beta recombination center

  5. hemogenic competency in recently specified endothelial progenitors is restrained through the active silencing of Runx1 expression.

  6. Leukaemogenesis by AML1-ETO (show RUNX1T1 Antibodies) requires enhanced C/D box snoRNA/RNP (show RNPC3 Antibodies) formation.

  7. In this study, we found upregulation of several hemostasis-related genes, including the thrombin (show F2 Antibodies)-activatable receptor PAR-1 (protease-activated receptor-1 (show F2R Antibodies)), in Runx1/Cbfb (show CBFB Antibodies)-deleted MLL (show MLL Antibodies)-AF9 (show MLLT3 Antibodies) cells. Similar to the effect of Runx1/Cbfb (show CBFB Antibodies) deletion, PAR-1 (show MARK2 Antibodies) overexpression induced CDKN1A/p21 (show CDKN1A Antibodies) expression and attenuated proliferation in MLL (show MLL Antibodies)-AF9 (show MLLT3 Antibodies) cells

  8. Immunohistochemical staining for RUNX1 showed reactivity in angiogenic tufts in the retina of mice with oxygen-induced retinopathy, suggesting that RUNX1 upregulation is a hallmark of aberrant retinal angiogenesis.

  9. The Runx1-persistent group is involved in transmitting mechanical and thermal information, whereas the Runx1-transient group transmits pruriceptive information. Such hierarchical control mechanisms may provide a developmental solution for the formation of sensory circuits that transmit distinct modalities.

  10. RUNX1 was expressed in both mesenchymal and epithelial compartments of the developing and postnatal lung. Increased respiratory distress, inflammation, and proinflammatory cytokines were observed in the Runx1-deleted mice after pulmonary LPS (show TLR4 Antibodies) exposure. RUNX1 deletion was associated with the activation of NF-kappaB (show NFKB1 Antibodies) in respiratory epithelial cells. RUNX1 was required for the suppression of NF-kappaB (show NFKB1 Antibodies) signaling pathway.

Human Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. discussion of the role of RUNX1 in diseases caused by their mutations or deletions (review)

  2. Placental hematopoietic stem and progenitor cells likely arise from hematopoietic niches comprised RUNX1+ mesenchyme and vascular endothelium. Pregnancy complications that result in preterm birth differentially affect placental hematopoietic stem and progenitor cells localization and RUNX1 expression

  3. deficiency alters the expression of a crucial subset of TAL1 (show TAL1 Antibodies)- and NOTCH1 (show NOTCH1 Antibodies)-regulated genes, including the MYB (show MYB Antibodies) and MYC (show MYC Antibodies) oncogenes, respectively.

  4. Our findings strengthen previous data concerning RUNX1 mutations in acute myeloid leukemia (show BCL11A Antibodies) and support the notion that RUNX1 mutational status should be integrated into a diagnostic workup of acute myeloid leukemia (show BCL11A Antibodies).

  5. Heterozygous germ line mutations in the RUNX1 gene are responsible genetic events for FPD/AML.

  6. Data suggest that RUNX1 pays dual roles in normal female sexual development/maturation and tumorigenesis in female-related cancers; "alterations" in RUNX1, either mutations in RUNX1 gene or variations in expression of RUNX1, appear to be associated with breast, ovarian, uterine, and cervical neoplasms. [REVIEW]

  7. The E3 ubiquitin ligase (show MUL1 Antibodies) STUB1 (show STUB1 Antibodies) is a negative regulator of both RUNX1 and RUNX1-RUNX1T1 (show RUNX1T1 Antibodies). Activation of STUB1 (show STUB1 Antibodies) could be a promising therapeutic strategy for RUNX1-RUNX1T1 (show RUNX1T1 Antibodies) leukemia.

  8. The clinical significance of ETV6 (show ETV6 Antibodies)-RUNX1.

  9. Deliver the necessary promotional drive for the progression of ETV6 (show ETV6 Antibodies)-RUNX1+ pre-leukaemic cells.

  10. High RUNX1 expression is associated with pancreatic cancer.

Zebrafish Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Our data suggest that runx1 and cbfb are required at 2 different steps during early hematopoietic stem cell development

  2. We propose that cohesin and CTCF (show CTCF Antibodies) have distinct functions in the regulation of runx1 during zebrafish embryogenesis.

  3. Morpholino knockdown of Myef2 (show MYEF2 Antibodies) or Runx1 in zebrafish results in reduced numbers of hematopoietic stem cells, suggesting that these two factors also interact in vivo to regulate hematopoiesis.

  4. Runx1 is induced by high Pu.1 level and in turn transrepresses pu.1 expression, thus constituting a negative feedback loop that fashions a favorable Pu.1 level required for balanced fate commitment to neutrophils versus macrophages.

  5. hematopoietic stem cell numbers depended on activity of the transcription factor Runx1, on blood flow, and on proper development of the dorsal aorta

  6. in zebrafish adult HSCs can be formed without an intact runx1.

  7. Zebrafish embryos lacking Rad21 (show RAD21 Antibodies), or cohesin subunit Smc3 (show SMC3 Antibodies), fail to express runx3 (show RUNX3 Antibodies) and lose hematopoietic runx1 expression in early embryonic development.

Xenopus laevis Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Xaml1/Runx1 is required for the specification of Rohon-Beard sensory neurons in Xenopus.

  2. ETV6-RUNX1 (TEL-AML1) fusion and hyperdiploidy (>50 chromosomes) are favorable genetic features in childhood acute lymphoblastic leukemia (ALL).

  3. reveal a shift in Runx2 (show RUNX2 Antibodies) function protein during vertebrate evolution towards its exclusive roles in cartilage hypertrophy and bone differentiation within the amniote lineage

RUNX1 Antigen Profile

Protein Summary

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with RUNX1

  • runt-related transcription factor 1 (RUNX1) antibody
  • runt-related transcription factor (runt) antibody
  • runt related transcription factor 1 (Runx1) antibody
  • runt-related transcription factor 1 (runx1) antibody
  • runt-related transcription factor 1 (Runx1) antibody
  • AI462102 antibody
  • aml antibody
  • aml-1 antibody
  • Aml1 antibody
  • aml1-evi-1 antibody
  • amlcr1 antibody
  • cbfa2 antibody
  • evi-1 antibody
  • Pebp2a2 antibody
  • pebp2ab antibody
  • Pebpa2b antibody
  • Runx-1 antibody
  • runx1 antibody
  • runxa antibody
  • XAML antibody
  • Xaml1 antibody

Protein level used designations for RUNX1

runt-related transcription factor 1 , runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) , runt-related transcription factor , runt protein , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core binding factor alpha 2 , core-binding factor subunit alpha-2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit , runt domain, alpha subunit 2 , AML1-EVI-1 fusion protein , core-binding factor, runt domain, alpha subunit 2 , aml1 , runt-related transcription factor a , runx1a , Acute myeloid leukemia 1 protein , Core-binding factor subunit alpha-2 , aml1 oncogene , ch-runtB2 , acute myeloid leukemia 1 , factor, runt domain, alpha subunit 2 , core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene) , runt related transcription factor 1

GENE ID SPECIES
473981 Pan troglodytes
100302713 Saccoglossus kowalevskii
12394 Mus musculus
861 Homo sapiens
58126 Danio rerio
379657 Xenopus laevis
396152 Gallus gallus
487746 Canis lupus familiaris
529631 Bos taurus
50662 Rattus norvegicus
100512633 Sus scrofa
100724149 Cavia porcellus
Selected quality suppliers for anti-RUNX1 (RUNX1) Antibodies
Did you look for something else?