anti-Runt-Related Transcription Factor 3 (RUNX3) Antibodies

RUNX3 encodes a member of the runt domain-containing family of transcription factors. Additionally we are shipping RUNX3 Proteins (13) and RUNX3 Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RUNX3 12399  
RUNX3 864 Q13761
RUNX3 156726  
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Top anti-RUNX3 Antibodies at antibodies-online.com

Showing 10 out of 218 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-RUNX3 Antibody Titration: </b>1.25ug/ml<br><b>ELISA Titer: </b>1:12500<br><b>Positive Control: </b>NIH/3T3 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- RUNX3 Picoband antibody, IHC(P) IHC(P): Rat Spleen Tissue Anti- RUNX3 Picoband antibody, IHC(P) IHC(P): Human Intestinal Cancer Tissue 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Mouse Un-conjugated CyTOF, FACS, ICC, SimWes, WB Detection of Human RUNX3/CBFA3 by Simple WesternTM. Simple Western lane view shows lysates of Jurkat human acute T cell leukemia cell line and Daudi human Burkitt's lymphoma cell line, loaded at 0.5 mg/mL. A specific band was detected for RUNX3/CBFA3 at approximately 54 kDa (as indicated) using 10 ug/mL of Mouse Anti-Human/Mouse RUNX3/CBFA3 Monoclonal Antibody. This experiment was conducted under reducing conditions and using the 12-230 kDa separation system. Detection of RUNX3/CBFA3 in Human PBMC by Flow Cytometry. Human PBMC unstimulated (light orange filled histogram) or treated with 50ng/mL PMA (dark orange filled histogram) were stained with Mouse Anti-Human/Mouse RUNX3/CBFA3 Monoclonal Antibody. To facilitate intracellular staining, cells were fixed with paraformaldehyde and permeabilized with saponin. 100 μg Log in to see 8 to 9 Days
$266.70
Details
Human Mouse Allophycocyanin FACS Detection of RUNX3/CBFA3 in Human PBMC lymphocytes by Flow Cytometry. Human peripheral blood mononuclear cells (PBMC) lymphocytes either (A) untreated or (B) treated with PMA were stained with Mouse Anti-Human RUNX3/CBFA3 APC-conjugated Monoclonal Antibody. Detection of RUNX3/CBFA3 in Human PBMC lymphocytes by Flow Cytometry. Human peripheral blood mononuclear cells (PBMC) lymphocytes either (A) untreated or (B) treated with PMA were stained with Mouse Anti-Human RUNX3/CBFA3 APC-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$351.75
Details
Human Mouse Un-conjugated ICC, FACS, IHC, ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$430.10
Details
Cow Rabbit Un-conjugated WB 100 μg Log in to see 7 to 9 Days
$493.17
Details
Mouse Rabbit Un-conjugated WB Anti- RUNX3 antibody, Western blotting All lanes: Anti RUNX3  at 0.5ug/ml Lane 1: Rat Liver Tissue Lysate at 50ug Lane 2: Mouse Liver Tissue Lysate at 50ug Predicted bind size: 44KD Observed bind size: 44KD 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Rabbit Un-conjugated IF, IHC (p), WB RUNX3 Antibody (Center) (ABIN658684) western blot analysis in HL-60 cell line lysates (35 µg/lane). This demonstrates the RUNX3 antibody detected the RUNX3 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 16 Days
$175.80
Details
Human Mouse Un-conjugated ELISA, WB RUNX3 polyclonal antibody (A01), Lot # 070226JCSa Western Blot analysis of RUNX3 expression in HepG2 . Western Blot detection against Immunogen (35.57 KDa) . 50 μL Log in to see 11 to 12 Days
$298.57
Details

RUNX3 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-RUNX3 Antibodies

  1. Human Polyclonal RUNX3 Primary Antibody for EMSA - ABIN3434042 : Peng, Wei, Wang, Tang, Zhang, Le, Jia, Li, Xie: RUNX3 inhibits the expression of vascular endothelial growth factor and reduces the angiogenesis, growth, and metastasis of human gastric cancer. in Clinical cancer research : an official journal of the American Association for Cancer Research 2006 (PubMed)
    Show all 6 Pubmed References

  2. Human Monoclonal RUNX3 Primary Antibody for ICS, IHC (p) - ABIN2689899 : Chuang, Ito, Ito: RUNX family: Regulation and diversification of roles through interacting proteins. in International journal of cancer. Journal international du cancer 2013 (PubMed)
    Show all 6 Pubmed References

  3. Human Polyclonal RUNX3 Primary Antibody for ELISA, WB - ABIN560191 : Nakamura, Senzaki, Yoshikawa, Nishimura, Inoue, Ito, Ozaki, Shiga: Dynamic regulation of the expression of neurotrophin receptors by Runx3. in Development (Cambridge, England) 2008 (PubMed)
    Show all 5 Pubmed References

  4. Human Monoclonal RUNX3 Primary Antibody for CyTOF, FACS - ABIN4899364 : Chopin, Seillet, Chevrier, Wu, Wang, Morse, Belz, Nutt: Langerhans cells are generated by two distinct PU.1-dependent transcriptional networks. in The Journal of experimental medicine 2013 (PubMed)
    Show all 2 Pubmed References

  5. Human Polyclonal RUNX3 Primary Antibody for IF, IHC (p) - ABIN658684 : Zhu, Xu, Hu, Feng, Jiang, Hou, Cao, Han, Ling, Ge: Pim-1 acts as an oncogene in human salivary gland adenoid cystic carcinoma. in Journal of experimental & clinical cancer research : CR 2015 (PubMed)

  6. Human Monoclonal RUNX3 Primary Antibody for ICC, FACS - ABIN1724742 : Mei, Bai, Liu, Li, Wu, Yu, Zheng: RUNX3 expression is lost in glioma and its restoration causes drastic suppression of tumor invasion and migration. in Journal of cancer research and clinical oncology 2011 (PubMed)

  7. Human Polyclonal RUNX3 Primary Antibody for IF, IHC (p) - ABIN514065 : Shi, Wang, Liu, Chen: Inactivation of RUNX3 predicts poor prognosis in esophageal squamous cell carcinoma after Ivor-Lewis esophagectomy. in Medical oncology (Northwood, London, England) 2014 (PubMed)

More Antibodies against RUNX3 Interaction Partners

Zebrafish Runt-Related Transcription Factor 3 (RUNX3) interaction partners

  1. In neuronal fate determination, Runx co-factor Cbfbeta (show CBFB Antibodies) is essential for its function, but the high level of Runx3 expression can overcome the loss of Cbfbeta (show CBFB Antibodies), demonstrating that Cbfbeta (show CBFB Antibodies) in this context serves solely as a signal amplifier of Runx3 activity.

  2. successive induction of the transcription factors Runx3, Egr1 and Sox9b constitutes a regulatory cascade that controls expression of Follistatin A in pharyngeal endoderm, the latter modulating BMP signaling in developing cranial cartilage in zebrafish

  3. Runx3 expression leads to an increase in primitive blood cell numbers, together with an increase in runx1 (show RUNX1 Antibodies)-expressing cells in the ventral wall of the dorsal aorta.

  4. Zebrafish embryos lacking Rad21 (show RAD21 Antibodies), or cohesin subunit Smc3 (show SMC3 Antibodies), fail to express runx3 and lose hematopoietic runx1 (show RUNX1 Antibodies) expression in early embryonic development.

Pig (Porcine) Runt-Related Transcription Factor 3 (RUNX3) interaction partners

  1. These results demonstrate that the CRISPR/Cas9 system is effective in inducing mutations on a specific locus of genome and the RUNX3 knockout pigs can be useful resources for human cancer research and to develop novel cancer therapies.

Mouse (Murine) Runt-Related Transcription Factor 3 (RUNX3) interaction partners

  1. Runx3-deficient CD8 (show CD8A Antibodies)(+) cytotoxic effector T cells aberrantly upregulated genes characteristic of follicular helper T (TFH) cell lineage, including Bcl6 (show BCL6 Antibodies), Tcf7 (show TCF7 Antibodies) and Cxcr5 (show CXCR5 Antibodies). Mechanistically, the Runx3-CBFbeta (show CBFB Antibodies) transcription factor complex deployed H3K27me3 to Bcl6 (show BCL6 Antibodies) and Tcf7 (show TCF7 Antibodies) genes to suppress the TFH program.

  2. Deletion of Runx3 in the peripheral nervous system or specifically in peripheral sensory neurons, or of enhancer elements driving Runx3 expression in proprioceptive neurons, induced prepubertal scoliosis.

  3. We found that Runx3 exerted a positive effect on early myeloid development

  4. Runx3 plays a crucial role in the hypothalamo-pituitary-gonadal axis

  5. intricate combinatorial interplay among the three regulatory elements governs Runx3 expression in distinct subtypes of TrkC (show NTRK3 Antibodies) neurons while concomitantly extinguishing its expression in non-TrkC (show NTRK3 Antibodies) neurons

  6. this study identifies a compensatory signaling mechanism that prevents lineage-fate errors by dynamically modulating Runx3d induction rates during MHC I positive selection

  7. our data suggest that Runx3 may play a crucial role in the development of DRGs by regulating the expression of Ntrk3 (show NTRK3 Antibodies) variants

  8. Runx3 is crucial for the phenotypic and functional changes observed in ThPok (show ZBTB7B Antibodies)-deficient invariant natural killer T cells.

  9. the transcription factor Runx3 was essential for the normal development of subsets of innate lymphoid cells (ILCs) in the mucosa

  10. Runx1 and Runx3 are the downstream effectors of Nanog, especially in the early and intermediate osteogenic differentiation of the mouse mesenchymal cell line C3H10T1/2.

Human Runt-Related Transcription Factor 3 (RUNX3) interaction partners

  1. The methylation status of Runx3 gene are abnormal in Hepatocellular Carcinoma patients, which may further be used as molecular markers for early diagnosis of Liver cancer.

  2. RUNX 3 hypermethylation is associated with breast cancer.

  3. High RUNX3 expression is associated with gastric cancer.

  4. we present evidence that RUNX3 can act as a tumor suppressor in a human T-cell malignancy and suggest that this effect is predominantly mediated through transcripts from its distal promoter, in particular RUNX3/p46 (show POLDIP3 Antibodies).

  5. Our results from clinical samples also suggest that Threonine 209 phosphorylation by Pak1 (show PAK1 Antibodies) could be a potential therapeutic target and of great clinical relevance with implications for Runx3 inactivation in cancer cells where Runx3 is known to be oncogenic. The findings presented in this study provide evidence of Runx3-Threonine 209 phosphorylation as a molecular switch in dictating the tissue-specific dualistic functions

  6. RUNX3 acts as a tumour suppressor

  7. MicroRNA-145 could regulate the balance of Th1 (show TH1L Antibodies)/Th2 through targeting the RUNX3 in asthma patients.

  8. The miR (show MLXIP Antibodies)-29b/KDM2A (show KDM2A Antibodies) axis was involved in the RUNX3-mediated inhibition of gastric cancer cell proliferation and metastasis.

  9. RUNX3 methylation level is associated with gastric cancer (GC), especially the methylation at site -1415 contributes to the poor prognosis in GC.

  10. The hypermethylation of RUNX3 in AFB1-transformed hepatocytes and human hepatocellular carcinomas implicates RUNX3 as a tumor suppressor gene

RUNX3 Antigen Profile

Protein Summary

This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with RUNX3

  • runt-related transcription factor 3 (runx3) antibody
  • runt-related transcription factor 3 (RUNX3) antibody
  • frRunx3/p45 (frrunx3) antibody
  • runt related transcription factor 3 (Runx3) antibody
  • runt-related transcription factor 3 (Runx3) antibody
  • AML2 antibody
  • Cbfa3 antibody
  • frrunx3 antibody
  • Pebp2a3 antibody
  • PEBP2aC antibody
  • runx3 antibody
  • runxb antibody

Protein level used designations for RUNX3

runt-related transcription factor b , runt-related transcription factor 3 , core-binding factor 3 , frRunx3/p45 , CBF-alpha-3 , PEA2-alpha C , PEBP2-alpha C , SL3-3 enhancer factor 1 alpha C subunit , SL3/AKV core-binding factor alpha C subunit , acute myeloid leukemia 2 protein , core binding factor alpha 3 , core-binding factor subunit alpha-3 , oncogene AML-2 , polyomavirus enhancer-binding protein 2 alpha C subunit , runt domain, alpha subunit 3 , transcription factor AML2/CBFA3 , PEA2 alpha C , PEBP2 alpha C , acute myeloid leukemia gene 2 , core-binding factor, runt domain, alpha subunit 3 , transcription factor AML2 , Runt related transcription factor 3 , Runx3 MASN-variant

GENE ID SPECIES
58127 Danio rerio
403159 Sus scrofa
456633 Pan troglodytes
100049632 Takifugu rubripes
100474431 Ailuropoda melanoleuca
100500732 Xenopus laevis
12399 Mus musculus
864 Homo sapiens
617389 Bos taurus
156726 Rattus norvegicus
769687 Gallus gallus
487366 Canis lupus familiaris
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