Runt-Related Transcription Factor 3 Proteins (RUNX3)

RUNX3 encodes a member of the runt domain-containing family of transcription factors. Additionally we are shipping RUNX3 Antibodies (218) and RUNX3 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RUNX3 12399  
RUNX3 864 Q13761
RUNX3 156726  
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Top RUNX3 Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 15 to 19 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see 10 to 12 Days
$229.85
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 11 to 12 Days
$313.60
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 2 to 3 Days
$364.64
Details
HOST_Escherichia coli (E. coli) Human His tag   1 mg Log in to see 2 to 3 Days
$5,769.50
Details
HOST_Escherichia coli (E. coli) Mouse T7 tag,His tag   100 μg Log in to see 15 to 18 Days
$320.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details

RUNX3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Human , ,
,
Rat (Rattus)

More Proteins for Runt-Related Transcription Factor 3 (RUNX3) Interaction Partners

Zebrafish Runt-Related Transcription Factor 3 (RUNX3) interaction partners

  1. In neuronal fate determination, Runx co-factor Cbfbeta (show CBFB Proteins) is essential for its function, but the high level of Runx3 expression can overcome the loss of Cbfbeta (show CBFB Proteins), demonstrating that Cbfbeta (show CBFB Proteins) in this context serves solely as a signal amplifier of Runx3 activity.

  2. successive induction of the transcription factors Runx3, Egr1 and Sox9b constitutes a regulatory cascade that controls expression of Follistatin A in pharyngeal endoderm, the latter modulating BMP signaling in developing cranial cartilage in zebrafish

  3. Runx3 expression leads to an increase in primitive blood cell numbers, together with an increase in runx1 (show RUNX1 Proteins)-expressing cells in the ventral wall of the dorsal aorta.

  4. Zebrafish embryos lacking Rad21 (show RAD21 Proteins), or cohesin subunit Smc3 (show SMC3 Proteins), fail to express runx3 and lose hematopoietic runx1 (show RUNX1 Proteins) expression in early embryonic development.

Pig (Porcine) Runt-Related Transcription Factor 3 (RUNX3) interaction partners

  1. These results demonstrate that the CRISPR/Cas9 system is effective in inducing mutations on a specific locus of genome and the RUNX3 knockout pigs can be useful resources for human cancer research and to develop novel cancer therapies.

Mouse (Murine) Runt-Related Transcription Factor 3 (RUNX3) interaction partners

  1. Runx3-deficient CD8 (show CD8A Proteins)(+) cytotoxic effector T cells aberrantly upregulated genes characteristic of follicular helper T (TFH) cell lineage, including Bcl6 (show BCL6 Proteins), Tcf7 (show TCF7 Proteins) and Cxcr5 (show CXCR5 Proteins). Mechanistically, the Runx3-CBFbeta (show CBFB Proteins) transcription factor complex deployed H3K27me3 to Bcl6 (show BCL6 Proteins) and Tcf7 (show TCF7 Proteins) genes to suppress the TFH program.

  2. Deletion of Runx3 in the peripheral nervous system or specifically in peripheral sensory neurons, or of enhancer elements driving Runx3 expression in proprioceptive neurons, induced prepubertal scoliosis.

  3. We found that Runx3 exerted a positive effect on early myeloid development

  4. Runx3 plays a crucial role in the hypothalamo-pituitary-gonadal axis

  5. intricate combinatorial interplay among the three regulatory elements governs Runx3 expression in distinct subtypes of TrkC (show NTRK3 Proteins) neurons while concomitantly extinguishing its expression in non-TrkC (show NTRK3 Proteins) neurons

  6. this study identifies a compensatory signaling mechanism that prevents lineage-fate errors by dynamically modulating Runx3d induction rates during MHC I positive selection

  7. our data suggest that Runx3 may play a crucial role in the development of DRGs by regulating the expression of Ntrk3 (show NTRK3 Proteins) variants

  8. Runx3 is crucial for the phenotypic and functional changes observed in ThPok (show ZBTB7B Proteins)-deficient invariant natural killer T cells.

  9. the transcription factor Runx3 was essential for the normal development of subsets of innate lymphoid cells (ILCs) in the mucosa

  10. Runx1 and Runx3 are the downstream effectors of Nanog, especially in the early and intermediate osteogenic differentiation of the mouse mesenchymal cell line C3H10T1/2.

Human Runt-Related Transcription Factor 3 (RUNX3) interaction partners

  1. RUNX3 mRNA and protein expression were upregulated in nasal-type extranodal NK/T-cell lymphoma (NKTL) patient samples and NKTL cell lines compared to normal NK cells. RUNX3 silenced NKTL cells showed increased apoptosis and reduced cell proliferation. MYC (show MYC Proteins) and RUNX3 binding occurs. Potential binding sites for MYC (show MYC Proteins) were identified in the RUNX3 enhancer region.

  2. The methylation status of Runx3 gene are abnormal in Hepatocellular Carcinoma patients, which may further be used as molecular markers for early diagnosis of Liver cancer.

  3. RUNX 3 hypermethylation is associated with breast cancer.

  4. High RUNX3 expression is associated with gastric cancer.

  5. we present evidence that RUNX3 can act as a tumor suppressor in a human T-cell malignancy and suggest that this effect is predominantly mediated through transcripts from its distal promoter, in particular RUNX3/p46 (show POLDIP3 Proteins).

  6. Our results from clinical samples also suggest that Threonine 209 phosphorylation by Pak1 (show PAK1 Proteins) could be a potential therapeutic target and of great clinical relevance with implications for Runx3 inactivation in cancer cells where Runx3 is known to be oncogenic. The findings presented in this study provide evidence of Runx3-Threonine 209 phosphorylation as a molecular switch in dictating the tissue-specific dualistic functions

  7. RUNX3 acts as a tumour suppressor

  8. MicroRNA-145 could regulate the balance of Th1 (show TH1L Proteins)/Th2 through targeting the RUNX3 in asthma patients.

  9. The miR (show MLXIP Proteins)-29b/KDM2A (show KDM2A Proteins) axis was involved in the RUNX3-mediated inhibition of gastric cancer cell proliferation and metastasis.

  10. RUNX3 methylation level is associated with gastric cancer (GC), especially the methylation at site -1415 contributes to the poor prognosis in GC.

RUNX3 Protein Profile

Protein Summary

This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with RUNX3

  • runt-related transcription factor 3 (runx3)
  • runt-related transcription factor 3 (RUNX3)
  • frRunx3/p45 (frrunx3)
  • runt related transcription factor 3 (Runx3)
  • runt-related transcription factor 3 (Runx3)
  • AML2 protein
  • Cbfa3 protein
  • frrunx3 protein
  • Pebp2a3 protein
  • PEBP2aC protein
  • runx3 protein
  • runxb protein

Protein level used designations for RUNX3

runt-related transcription factor b , runt-related transcription factor 3 , core-binding factor 3 , frRunx3/p45 , CBF-alpha-3 , PEA2-alpha C , PEBP2-alpha C , SL3-3 enhancer factor 1 alpha C subunit , SL3/AKV core-binding factor alpha C subunit , acute myeloid leukemia 2 protein , core binding factor alpha 3 , core-binding factor subunit alpha-3 , oncogene AML-2 , polyomavirus enhancer-binding protein 2 alpha C subunit , runt domain, alpha subunit 3 , transcription factor AML2/CBFA3 , PEA2 alpha C , PEBP2 alpha C , acute myeloid leukemia gene 2 , core-binding factor, runt domain, alpha subunit 3 , transcription factor AML2 , Runt related transcription factor 3 , Runx3 MASN-variant

GENE ID SPECIES
58127 Danio rerio
403159 Sus scrofa
456633 Pan troglodytes
100049632 Takifugu rubripes
100474431 Ailuropoda melanoleuca
100500732 Xenopus laevis
12399 Mus musculus
864 Homo sapiens
617389 Bos taurus
156726 Rattus norvegicus
769687 Gallus gallus
487366 Canis lupus familiaris
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