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anti-Ryanodine Receptor 1 (Skeletal) (RYR1) Antibodies

RYR1 encodes a ryanodine receptor found in skeletal muscle. Additionally we are shipping RYR1 Kits (13) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RYR1 6261 P21817
RYR1 114207  
RYR1 20190 E9PZQ0
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Top anti-RYR1 Antibodies at antibodies-online.com

Showing 10 out of 26 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 8 to 10 Days
$419.83
Details
Human Rabbit Un-conjugated EIA, IHC (fro), WB   0.1 mg Log in to see 6 to 8 Days
$555.50
Details
Zebrafish Rabbit Un-conjugated ELISA   250 μL Log in to see 8 to 10 Days
$449.17
Details
Human Rabbit Un-conjugated ICC, ELISA, WB   100 μL Log in to see 8 to 10 Days
$551.83
Details
Cow Mouse Un-conjugated EIA, FACS, IHC (fro), IF, WB   50 μg Log in to see 6 to 8 Days
$1,028.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   100 μg Log in to see 8 to 10 Days
$522.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of Mouse brain tissue, using RYR1 Polyclonal Antibody at dilution of 1:400 200 μL Log in to see 8 to 9 Days
$588.50
Details
Human Mouse Un-conjugated IHC (af), FACS, IF, ELISA, WB   50 μg Log in to see 11 to 16 Days
$1,364.29
Details
Human Rabbit HRP ELISA, WB   100 μg Log in to see 8 to 10 Days
$463.83
Details
Human Rabbit Biotin ELISA, WB   100 μg Log in to see 8 to 10 Days
$463.83
Details

RYR1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Rat (Rattus)
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Mouse (Murine)
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More Antibodies against RYR1 Interaction Partners

Zebrafish Ryanodine Receptor 1 (Skeletal) (RYR1) interaction partners

  1. Most of the ryanodine receptor (show RYR3 Antibodies) 1b (ryr1b) mRNA in mutants carried a nonsense mutation that was generated by aberrant splicing due to a DNA insertion in an intron of the ryr1b gene, leading to a hypomorphic condition in relatively relaxed mutants.

  2. sepn1 (show SEPN1 Antibodies) and ryr1 are required for the same cellular differentiation events and are needed for normal calcium fluxes

Turkey Ryanodine Receptor 1 (Skeletal) (RYR1) interaction partners

Human Ryanodine Receptor 1 (Skeletal) (RYR1) interaction partners

  1. This study demonstrated that the RYR1 mutation p.Arg4737Trp associated with susceptibility to malignant hyperthermia.

  2. Data show that the local Ca(2 (show CA2 Antibodies)+) signals observed within 20 ms upon microinjection of Jurkat cells with nicotinic acid adenine dinucleotide phosphate (NAADP) were sensitive to type 1 ryanodine receptor (RyR1) knockdown.

  3. A single nucleotide variant in the RYR1 gene is one of the responsible genes of idiopathic hyper CK-emia (persistent elevation of serum creatine kinase).

  4. We report 2 siblings with congenital ptosis and scoliosis who were considered for ptosis surgery but were found to harbor underlying recessive RYR1 mutations.

  5. Studies indicate that the ryanodine receptors (RyRs: RyR1, RyR2 (show RYR2 Antibodies), RyR3 (show RYR3 Antibodies)) and inositol 1,4,5-trisphosphate receptors (IP3Rs: IP3R1 (show ITPR1 Antibodies), IP3R2 (show ITPR2 Antibodies), IP3R3 (show ITPR3 Antibodies)) are the major Ca(2 (show CA2 Antibodies)+) release channels (CRCs) on the endo/sarcoplasmic reticulum (ER/SR).

  6. High-intensity interval training exercise induces a ROS (show ROS1 Antibodies)-dependent RyR1 fragmentation in muscles of recreationally active subjects, and the resulting changes in muscle fiber Ca(2 (show CA2 Antibodies)+)-handling trigger muscular adaptations

  7. This study demonistrated that RYR1 mutation releated to Centronuclear myopathy.

  8. unlike RyR1 normal WT RyR2 (show RYR2 Antibodies) does not bind dantrolene in spite of the fact that the RyR1 dantrolene-binding site (residues 590-609) is conserved in RyR2 (show RYR2 Antibodies)

  9. investigated spectrum of RYR-1 related disorders in a retrospective cohort study. 61 different mutations were detected, of which 24 were novel. Some mutations are present in both dominant (MHS) and recessive modes (congenital myopathy) of inheritance

  10. SPRY2 (show SPRY2 Antibodies) domain forms two antiparallel beta sheets establishing a core, and four additional modules of which several are required for proper folding

Cow (Bovine) Ryanodine Receptor 1 (Skeletal) (RYR1) interaction partners

  1. Gain of Ca(2 (show CA2 Antibodies)+)-induced Ca(2 (show CA2 Antibodies)+) release activity of RyR1 is markedly lower than that of RyR3 (show RYR3 Antibodies) in mammalian skeletal muscle, indicating selective stabilization of RyR1

Rabbit Ryanodine Receptor 1 (Skeletal) (RYR1) interaction partners

  1. RyR1-G4934A had reduced K(+) conductance and ion selectivity compared with WT. Mutations further increasing the side chain volume at these positions (G4934V and G4941I) resulted in reduced caffeine-induced Ca(2 (show CA2 Antibodies)+) release.

  2. Structural insights into the roles of divergent regions in RyR1 allosteric regulation during excitation contraction coupling.

  3. architecture of rabbit RyR1 at a resolution of 6.1 A, using electron cryomicroscopy

  4. closed-state structure of the 2.3-megadalton complex of the rabbit skeletal muscle type 1 RyR (RyR1), solved by single-particle electron cryomicroscopy at an overall resolution of 4.8 A

  5. Diminishing S-palmitoylation directly suppresses RyR1 activity as well as stimulus-coupled Ca(2 (show CA2 Antibodies)+) release through RyR1.

  6. Two regions of the ryanodine receptor (show RYR3 Antibodies) calcium channel are involved in Ca(2 (show CA2 Antibodies)+)-dependent inactivation

  7. Data indicate that S107 increased FKBP12 (show FKBP1A Antibodies) binding to RyR1 in sarcoplasmic reticulum vesicles in the presence of reduced glutathione and the NO-donor NOC12.

  8. These results suggest that the intersubunit contact region between N-terminal domains of RyR1 is a prime target for disease mutations.

  9. Sequence data of the ATP binding regions of the RyR1 protein was presented.

  10. a 2.2 A resolution crystal structure of the RyR domain revealing a two-fold, symmetric, extended four-helix bundle stabilized by a beta (show SUCLA2 Antibodies) sheet.

Pig (Porcine) Ryanodine Receptor 1 (Skeletal) (RYR1) interaction partners

  1. Interleukin 1, IL-2 (show IL2 Antibodies), IL-10 (show IL10 Antibodies), and TNF-alpha (show TNF Antibodies) measures were positively intercorrelated in each of the three RYR1 genotype group

  2. T-tubules proximity modulates RyR cluster properties resulting in intracellular heterogeneity of diastolic spark activity.

  3. Results support the hypothesis that Ca(2 (show CA2 Antibodies))(+) binding to CaM's C-terminal acts as the switch converting CaM (show CALM Antibodies) from a RyR1 activator into a channel inhibitor.

  4. The RYR1 genotype had a significant effect on IGF-2 expression in pig longissimus dorsi muscle.

  5. Binding to RyR1 targets evokes significant changes in calmodulin (show CALM Antibodies) structure and sensitivity.

  6. Significant interactions between CAST and RYR1 genotypes indicate that the quality of meat influenced by RYR1 genotype may be modified by the simultaneous influence of genotype as regards the CAST locus

  7. Our data suggest that non-coplanar PCBs are more potent and efficacious toward (MH)RyR1 than (Wt)RyR1, and have more profound effects on its cation regulation.

  8. stimulation of the RyR1 malignant hyperthermia susceptible channel caused by affected inter-domain interaction between regions 1 and 2 is an underlying mechanism for dysfunction of Ca2 (show CA2 Antibodies)+ homoeostasis seen in the malignant hyperthermia phenotype

  9. altered luminal Ca(2 (show CA2 Antibodies)+) regulation of RyR1 represents a primary causal mechanism of malignant hyperthermia

  10. Donor-acceptor distances derived from our FRET measurements provide insights into calmodulin (CaM (show CALM Antibodies))'s location and orientation within the RyR1 3D architecture and the conformational switching that underlies CaM (show CALM Antibodies) regulation of the channel

Mouse (Murine) Ryanodine Receptor 1 (Skeletal) (RYR1) interaction partners

  1. High-intensity interval training exercise induces a ROS (show ROS1 Antibodies)-dependent RyR1 fragmentation in muscles of recreationally active subjects, and the resulting changes in muscle fiber Ca(2 (show CA2 Antibodies)+)-handling trigger muscular adaptations

  2. The present study reveals that the C-terminal of the beta1a subunit changes conformation in the presence of RyR1 consistent with an interaction between the C-terminal of beta1a and RyR1 in resting myotubes.

  3. Ryanodine receptor (show RYR3 Antibodies) sensitization results in abnormal calcium signaling in airway smooth muscle cells.

  4. major finding from this study is the novel region- and cell-specific relationship between the localization of the plasma membrane Kv2.1 (show KCNB1 Antibodies) channel and intracellular RyR Ca2 (show CA2 Antibodies)+ release channels

  5. RyR1 is required for proper release of transmitter at the neuromuscular junction, and postsynaptic RyR1 is required for the size and distribution of acetylcholine receptor clusters.

  6. Spindle abnormalities precede those in extrafusal fibers, indicating that they are a primary pathological feature in this murine Ryr1-related core myopathy. [review]

  7. The motif Leu(496)-Leu(500)-Trp (show TYRP1 Antibodies)(503) within the bet1a C-terminal tail plays a nonessential role in the bidirectional DHPR (show QDPR Antibodies)/RyR1 signaling that supports skeletal-type excitation-contraction coupling.

  8. these results provide novel evidence that CaN regulates ASMC Ca(2 (show CA2 Antibodies)+) sparks specifically through RyR1, which plays an important role in the control of Ca(2 (show CA2 Antibodies)+) signaling and contraction in ASMCs.

  9. Results suggest that RyR1 and RyR2 (show RYR2 Antibodies) expressed by Purkinje and granule cells play important roles in promoting the dendritic differentiation of Purkinje cells and that RyR2 (show RYR2 Antibodies) expressed by granule cells is involved in the secretion of BDNF (show BDNF Antibodies) from granule cells

  10. Diminishing S-palmitoylation directly suppresses RyR1 activity as well as stimulus-coupled Ca(2 (show CA2 Antibodies)+) release through RyR1.

RYR1 Antigen Profile

Protein Summary

This gene encodes a ryanodine receptor found in skeletal muscle. The encoded protein functions as a calcium release channel in the sarcoplasmic reticulum but also serves to connect the sarcoplasmic reticulum and transverse tubule. Mutations in this gene are associated with malignant hyperthermia susceptibility, central core disease, and minicore myopathy with external ophthalmoplegia. Alternatively spliced transcripts encoding different isoforms have been described.

Gene names and symbols associated with RYR1

  • ryanodine receptor 1 (skeletal) (RYR1) antibody
  • ryanodine receptor 1a (skeletal) (ryr1a) antibody
  • ryanodine receptor 1 (skeletal) (Ryr1) antibody
  • ryanodine receptor 1, skeletal muscle (Ryr1) antibody
  • AI528790 antibody
  • alphaRYR antibody
  • CCO antibody
  • CRC antibody
  • MHS antibody
  • MHS1 antibody
  • RYDR antibody
  • Ryr antibody
  • RYR-1 antibody
  • RYR1 antibody
  • Ryr1l antibody
  • skrr antibody

Protein level used designations for RYR1

ryanodine receptor 1 (skeletal) , ryanodine receptor type 1 , ryanodine receptor 1a (slow muscle) , ryanodine receptor alpha isoform , central core disease of muscle , ryanodine receptor 1 , sarcoplasmic reticulum calcium release channel , skeletal muscle calcium release channel , skeletal muscle ryanodine receptor , type 1-like ryanodine receptor , skeletal muscle-type ryanodine receptor , type 1 ryanodine receptor , ryanodine receptor 1, skeletal muscle , ryanodine receptor 1-like, skeletal muscle , RYR-1 , calcium release channel , halothane , porcine stress syndrome

GENE ID SPECIES
396112 Gallus gallus
719601 Macaca mulatta
798565 Danio rerio
100008574 Meleagris gallopavo
100034090 Equus caballus
100612063 Pan troglodytes
6261 Homo sapiens
606491 Canis lupus familiaris
100139857 Bos taurus
100009540 Oryctolagus cuniculus
114207 Rattus norvegicus
396718 Sus scrofa
20190 Mus musculus
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