S100 Calcium Binding Protein A4 Proteins (S100A4)

The protein encoded by S100A4 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. Additionally we are shipping s100a4 Antibodies (237) and s100a4 Kits (31) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
S100A4 6275 P26447
S100A4 20198 P07091
S100A4 24615 P05942
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Top s100a4 Proteins at antibodies-online.com

Showing 10 out of 39 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human Fc Tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_Human Cells Mouse Fc Tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 15 to 19 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 10 μg Log in to see 3 to 4 Days
$155.00
Details
HOST_Wheat germ Human GST tag   10 μg Log in to see 11 to 12 Days
$405.71
Details

S100A4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine) ,
,
Rat (Rattus)

Top referenced s100a4 Proteins

  1. Mouse (Murine) s100a4 Protein expressed in Human Cells - ABIN2007870 : Ambartsumian, Tarabykina, Grigorian, Tulchinsky, Hulgaard, Georgiev, Lukanidin: Characterization of two splice variants of metastasis-associated human mts1 gene. in Gene 1995 (PubMed)
    Show all 7 references for 2007870

  2. Human s100a4 Protein expressed in Human Cells - ABIN2002274 : Helfman, Kim, Lukanidin, Grigorian: The metastasis associated protein S100A4: role in tumour progression and metastasis. in British journal of cancer 2005 (PubMed)
    Show all 6 references for 2002274

  3. Mouse (Murine) s100a4 Protein expressed in Escherichia coli (E. coli) - ABIN2007872 : Saleem, Kweon, Johnson, Adhami, Elcheva, Khan, Bin Hafeez, Bhat, Sarfaraz, Reagan-Shaw, Spiegelman, Setaluri, Mukhtar: S100A4 accelerates tumorigenesis and invasion of human prostate cancer through the transcriptional regulation of matrix metalloproteinase 9. in Proceedings of the National Academy of Sciences of the United States of America 2006 (PubMed)
    Show all 6 references for 2007872

  4. Human s100a4 Protein expressed in Escherichia coli (E. coli) - ABIN2002276 : Marenholz, Heizmann, Fritz: S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature). in Biochemical and biophysical research communications 2004 (PubMed)
    Show all 5 references for 2002276

  5. Human s100a4 Protein expressed in Wheat germ - ABIN1319061 : Mencía, Selga, Rico, de Almagro, Villalobos, Ramirez, Adan, Hernández, Noé, Ciudad: Overexpression of S100A4 in human cancer cell lines resistant to methotrexate. in BMC cancer 2010 (PubMed)
    Show all 2 references for 1319061

  6. Human s100a4 Protein expressed in Escherichia coli (E. coli) - ABIN667107 : Sherbet: Metastasis promoter S100A4 is a potentially valuable molecular target for cancer therapy. in Cancer letters 2009 (PubMed)
    Show all 2 references for 667107

More Proteins for S100 Calcium Binding Protein A4 (S100A4) Interaction Partners

Human S100 Calcium Binding Protein A4 (S100A4) interaction partners

  1. S100a4 is expressed in a limited number of stromal cells throughout the colon. S100A4 was mainly localised in the colorectal tumour-associated stroma, it was also detectable in a limited number of epithelial tumour cells.

  2. our results suggest the existence of evolutionarily conserved pathways used by S100A4 to promote metastatic dissemination

  3. miR (show MLXIP Proteins)-187-3p inhibits the migration/metastasis and epithelial mesenchymal transition in hepatocellular carcinoma by targeting S100A4 expression.

  4. our findings highlight nuclear S100A4 as a candidate therapeutic target in cholangiocarcinoma and establish a mechanistic rationale for the use of low-dose paclitaxel in blocking metastatic progression of cholangiocarcinoma

  5. The increased content of collagen fibers and overexpression of S100A4 and P53 (show TP53 Proteins) may play an important role in myocardial fibrosis of HCM, and they can be used in future HCM research. Blockade of S100A4 may have therapeutic potential in HCM by attenuating cardiac fibrosis.

  6. The experimental and in silico results suggest two divergent evolutionary pathways: NMIIA and NMIIB evolved to possess S100A4-dependent and -independent regulations, respectively.

  7. Results found that CNE-1 nasopharyngeal carcinoma cell (NPC (show NPC1 Proteins)) line expressing S100A4 showed significantly increased invasion ability in vitro and in vivo. Also, it seems that aberrant DNA hypomethylation of its promotor region might lead to the metastasis progression in EBV-associated NPC (show NPC1 Proteins).

  8. Oct-1 (show POU2F1 Proteins) modifies S100A4 exchange between intra- and extracellular compartments in Namalwa cells and increases their sensitivity to glucocorticoids.

  9. ChIP studies showed that the S100A4 protein binds to the GDF15 (show GDF15 Proteins) promoter, implicating S100A4 in GDF15 (show GDF15 Proteins) regulation at the transcriptional level.

  10. Cell invasion (matrigel) was reduced only in the Hs578T cells (p < 0.01). Silencing decreased the expression of the prometastatic molecules S100A4 and TGFbetaR2 in both cell lines and CD44 (show CD44 Proteins) in Hs578T cells .We conclude that ECM1 (show ECM1 Proteins) is a key player in the metastatic process and regulates the actin cytoskeletal architecture of aggressive breast cancer cells at least in part via alterations in S100A4 and Rho A (show RHOA Proteins).

Mouse (Murine) S100 Calcium Binding Protein A4 (S100A4) interaction partners

  1. Data provide the first report on the in vivo role of S100a4 in intestinal tumourigenesis and describe a new role for S100a4 in the aetiology of desmoids formation.

  2. S100A4 expression protects cardiac myocytes against myocardial ischemia and is required for stabilization of cardiac function after MI.

  3. These findings provide further evidence on extracellular S100A4 as paracrine mediator of prometastatic endothelial dysfunction involving its interaction with RAGE (show AGER Proteins).

  4. this study has demonstrated a crucial role for retinoic acid in promoting IL-22 (show IL22 Proteins) production and tempering dendritic cell function through downregulating S100A4 protein during viral hepatitis

  5. Extracellular S100A4 is important for the regulation of bone formation by activating the NF-kappaB (show NFKB1 Proteins) signaling pathway in osteoblasts.

  6. Interaction of extracellular S100A4 with RAGE (show AGER Proteins) prompts prometastatic activation of melanoma cells.

  7. Our results indicated that RNV was ameliorated by Ad-S100A4-RNAi transfer in a mouse model of OIR through mediation of the anti-apoptotic effect of Bcl-2 (show BCL2 Proteins) by reducing the expression of CREB (show CREB1 Proteins).

  8. The thymic CD45 (show PTPRC Proteins)-FSP1+ cells are a subpopulation of fibroblasts, which is crucial for the maintenance and regeneration of thymic epithelial cells.

  9. Enhanced S100A4 expression was observed in remodeled intrapulmonary arteries of mice with smoke-induced emphysema.

  10. Downregulation of AKT3 (show AKT3 Proteins) increases migration and metastasis in triple negative breast cancer cells by upregulating S100A4.

s100a4 (S100A4) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Gene names and symbols associated with S100A4

  • S100 calcium binding protein A4 (S100A4)
  • S100 calcium-binding protein A4 (LOC100349003)
  • S100 calcium binding protein A4 (S100a4)
  • S100 calcium-binding protein A4 (S100a4)
  • 18A2 protein
  • 42a protein
  • Capl protein
  • FSp1 protein
  • metastasin protein
  • Mts1 protein
  • P9ka protein
  • PeL98 protein
  • pk9a protein
  • RNP9KA protein
  • S100A4 protein

Protein level used designations for S100A4

S100 calcium binding protein A4 , S100 calcium-binding protein A4 , S100 calcium-binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog) , fibroblast-specific protein-1 , leukemia multidrug resistance associated protein , malignant transformation suppression 1 , placental calcium-binding protein , protein Mts1 , protein S100-A4 , S100 calcium binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog) , metastasin , S100 calcium-binding protein A4 (calcium protein,calvasculin, metastasin, murine placental homolog) , placental calcium-binding protein homolog , calvasculin , metastatic cell protein , protein 18A2 , P9K , Protein 9 Ka homologous to calcium-binding protein , nerve growth factor-induced protein 42A

GENE ID SPECIES
457320 Pan troglodytes
715115 Macaca mulatta
100349003 Oryctolagus cuniculus
6275 Homo sapiens
403787 Canis lupus familiaris
101083141 Felis catus
282343 Bos taurus
20198 Mus musculus
100723950 Cavia porcellus
24615 Rattus norvegicus
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