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The protein encoded by S100A8 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping S100A8 Proteins (1) and many more products for this protein.
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MRP8 elevated serum levels in patients with Behcet's disease indicate MRP8 role in the pathogenetic mechanisms of Behcet's disease.
The ABCC11 gene SNP of the 538 G>A allele was associated with a downregulation of the mRNA expression of ApoD (show APOD Antibodies) in the apocrine glands, which may indicate a role for the ABCC11 gene in the mediation of osmidrosis
study revealed a novel role of MRP8/14 in the autophagy-mediated elimination of intracellular BCG (show SLC11A1 Antibodies) by promoting reactive oxygen species generation
Circulating MRP-8/14 is associated with TX-dependent platelet activation in ACS (show PLA2G15 Antibodies), even during low-dose aspirin treatment, suggesting a contribution of residual TX to MRP-8/14 shedding, which may further amplify platelet activation.
Data suggest that tissue infiltrating macrophages secreting MRP8/14 may contribute to myositis, by driving the local production of cytokines directly from muscle.
MRP8/14 can activate cells by binding to TLR4 (show TLR4 Antibodies), leading to the release of proinflammatory cytokines. These mediators can lead to increased disease activity in enthesitis-related arthritis.
Our results suggest that a specific type of toxicity, leukopenia, is associated with a particular variant of ABCC11, which is different from the earwax and eQTL variants.
High baseline serum MRP8/14 levels are associated with lower survival in Chinese peritoneal dialysis patients.
MRP8 has a crucial role in stimulating IL-6 (show IL6 Antibodies) expression by rheumatoid arthritis fibroblast-like synoviocytes.
High expression of ATP-binding cassette transporter (show ABCA4 Antibodies) ABCC11 in breast tumors is associated with aggressive subtypes and low disease-free survival.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene.
ATP-binding cassette protein C11
, ATP-binding cassette sub-family C member 11
, ATP-binding cassette transporter MRP8
, ATP-binding cassette transporter sub-family C member 11
, multi-resistance protein 8
, multidrug resistance-associated protein 8