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The protein encoded by S100A8 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. Additionally we are shipping S100A8 Kits (45) and S100A8 Proteins (42) and many more products for this protein.
Showing 10 out of 211 products:
Human Monoclonal S100A8 Primary Antibody for EIA, IHC (fro) - ABIN111890
Brandtzaeg, Jones, Flavell, Fagerhol: Mac 387 antibody and detection of formalin resistant myelomonocytic L1 antigen. in Journal of clinical pathology 1989
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Human Monoclonal S100A8 Primary Antibody for EIA, IHC (fro) - ABIN111891
Odink, Cerletti, Brüggen, Clerc, Tarcsay, Zwadlo, Gerhards, Schlegel, Sorg: Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis. in Nature 1987
Show all 10 references for ABIN111891
Human Monoclonal S100A8 Primary Antibody for DB, EIA - ABIN111892
Delabie, de Wolf-Peeters, van den Oord, Desmet: Differential expression of the calcium-binding proteins MRP8 and MRP14 in granulomatous conditions: an immunohistochemical study. in Clinical and experimental immunology 1990
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Human Monoclonal S100A8 Primary Antibody for EIA, FACS - ABIN111893
Hogg, Allen, Edgeworth: Monoclonal antibody 5.5 reacts with p8,14, a myeloid molecule associated with some vascular endothelium. in European journal of immunology 1989
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Human Monoclonal S100A8 Primary Antibody for ELISA, WB - ABIN393635
Schenten, Bréchard, Plançon, Melchior, Frippiat, Tschirhart: iPLA2, a novel determinant in Ca2+- and phosphorylation-dependent S100A8/A9 regulated NOX2 activity. in Biochimica et biophysica acta 2010
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Human Monoclonal S100A8 Primary Antibody for FACS, IF - ABIN954652
Klein, Pino, Johnson, Davies, Nagpal, Thacher, Krasinski, Chandraratna: Identification and functional separation of retinoic acid receptor neutral antagonists and inverse agonists. in The Journal of biological chemistry 1996
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Human Monoclonal S100A8 Primary Antibody for FACS, IF - ABIN954653
Nagpal, Thacher, Patel, Friant, Malhotra, Shafer, Krasinski, Asano, Teng, Duvic, Chandraratna: Negative regulation of two hyperproliferative keratinocyte differentiation markers by a retinoic acid receptor-specific retinoid: insight into the mechanism of retinoid action in psoriasis. in Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997
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Human Monoclonal S100A8 Primary Antibody for EIA, WB - ABIN1108923
Amano, Kanda, Shibayama, Kamei, Matsuda: Model generation interface for simulation of left ventricular motion. in Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2007
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Human Monoclonal S100A8 Primary Antibody for FACS, IF - ABIN954654
Thacher, Nagpal, Klein, Arefieg, Krasinski, DiSepio, Agarwal, Johnson, Eckert, Chandraratna: Cell type and gene-specific activity of the retinoid inverse agonist AGN 193109: divergent effects from agonist at retinoic acid receptor gamma in human keratinocytes. in Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1999
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Suggest that, in individuals with lichen planus, S100A8 may exert distinct immunomodulatory and cytotoxicity functions.
Serum calprotectin was significantly higher in rheumatoid arthritis patients than controls, and was correlated with disease activity. It was higher in seropositive than in seronegative patients.
S100A8, S100A9 (show S100A9 Antibodies) and S100A8/A9 protein levels were higher in chronic rhinosinusitis (CRS (show CARS Antibodies)) with nasal polyps (NP) patients, showing increased deposition on extracellular matrix (ECM (show MMRN1 Antibodies)) structures in contrast to CRS (show CARS Antibodies) without NP and controls.
MRP8/14 is a good marker of disease activity in rheumatoid arthritis, and higher levels predict response to methotrexate.
Blood expression of matrix metalloproteinases 8 and 9 and of their inducers S100A8 and S100A9 (show S100A9 Antibodies) supports diagnosis and prognosis of PDAC-associated diabetes mellitus
Increased MRP8/14 levels suggest the instability of the atherosclerotic plaque. ECP (show ECP Antibodies) reflects the severity of coronary arteries stenosis, predicting atherosclerosis burden. They may become the new biomarkers of CAD (show CAD Antibodies).
Findings suggest that S100 proteins S100A12 (show S100A12 Antibodies) and S100A8/A9 are secreted independently either via distinct mechanisms of secretion or following the activation of different signal transduction pathways.
Data suggest up-regulation of pro-inflammatory molecules TLR9 (show TLR9 Antibodies), S100A8, and IL-8 (show IL8 Antibodies) plus lower levels of CD11b (show ITGAM Antibodies)+ CD33 (show CD33 Antibodies)+ myeloid cells may be involved in impairment of wound healing in type 2 diabetes leading to chronic ulcers, such as diabetic foot ulcers.
Elevated expression of MRP8/14 are associated with poor prognosis in lupus nephritis.
BBP (show TP53BP2 Antibodies) exposure also increased tumor infiltrating myeloid-derived suppressor cell (MDSC) secretion of S100A8/A9, thereby exacerbating the resistance of breast cancer to doxorubicin with cyclophosphamide
Study verified porcine calprotectin (S100A8/A9) expression at the protein level in multiple Haemophilus parasuis infected tissues and explored their molecular characterization.
Data suggest that up-regulation of S100A8 and S100A9 (show S100A9 Antibodies) is a key component of early endometrial response to uterine involution in the post-partum period and to prevent chronic endometritis/uterine inflammation; up-regulation can be influenced by diet.
S100a8 upregulation triggers NF-kappaB (show NFKB1 Antibodies) signal pathway through RAGE (show AGER Antibodies) and TLR4 (show TLR4 Antibodies), in response to laser-induced dermis wound healing.
Although MRP-8/-14 expression is highly increased in experimental, these proteins do not contribute to the pathogenesis in the effector phase of epidermolysis bullosa acquisita and bullous pemphigoid (show DST Antibodies).
TLR4 (show TLR4 Antibodies), TLR2 (show TLR2 Antibodies) also contributed to Mrp8-induced inflammatory response and tolerance.
S100A8 appears to play a crucial role in the activation of the TLR4 (show TLR4 Antibodies)/MD-2 (show LY96 Antibodies) pathway and the promotion of a tumor growth-enhancing immune microenvironment.
Rps14 (show RPS14 Antibodies) haploinsufficiency in del(5q) myelodysplastic syndrome is linked to activation of the innate immune system and induction of S100A8-S100A9 (show S100A9 Antibodies) expression, leading to a p53 (show TP53 Antibodies)-dependent erythroid differentiation defect.
S100A8 is primarily produced from CXCR2 (show CXCR2 Antibodies)-expressing CD11b (show ITGAM Antibodies)(+)Gr-1 (show GSR Antibodies)(high) cells, and it upregulates TNF-alpha (show TNF Antibodies) production in CD11b (show ITGAM Antibodies)(+)F4/80(+) cells through cellular cross-talk, which is an important mechanism in the development of Nonalcoholic fatty liver disease
Alarmins S100A8/S100A9 (show S100A9 Antibodies) aggravate osteophyte formation in experimental osteoarthritis and predict osteophyte progression in early human symptomatic osteoarthritis.
This study identified Mrp8/14 and TLR4 (show TLR4 Antibodies) as important modulators of the leukocyte recruitment cascade during inflammation via integrin beta2.
Inflammation-induced S100A8 promotes colorectal tumorigenesis by acting upstream to activate the Akt1 (show AKT1 Antibodies)-Smad5 (show SMAD5 Antibodies)-Id3 (show ID3 Antibodies) axis.
Data shows that S100A8/A9 plays a critical role during glomerulonephritis, exerting and amplifying autocrine and paracrine proinflammatory effects on bone marrow-derived macrophages, renal endothelial cells, and mesangial cells.
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis.
S100 calcium binding protein A8
, S100 calcium-binding protein A8 (calgranulin A)
, calgranulin A
, calprotectin L1L subunit
, cystic fibrosis antigen
, leukocyte L1 complex light chain
, migration inhibitory factor-related protein 8
, protein S100-A8
, urinary stone protein band A
, S100 calcium binding protein A8 (calgranulin A)
, S100 calcium-binding protein A8
, neutrophil cytosolic 7 kDa protein
, chemotactic S100 protein
, chemotactic cytokine CP-10
, pro-inflammatory S100 cytokine