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S100 Calcium Binding Protein A8 Proteins (S100A8)

The protein encoded by S100A8 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. Additionally we are shipping S100A8 Antibodies (170) and S100A8 Kits (53) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
S100A8 6279 P05109
S100A8 116547 P50115
S100A8 20201 P27005
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Top S100A8 Proteins at antibodies-online.com

Showing 10 out of 39 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated Figure annotation denotes ug of protein loaded and % gel used. 100 μg Log in to see 7 to 9 Days
$534.64
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 16 to 41 Days
$242.00
Details
HOST_Baculovirus infected Insect Cells Human His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$616.00
Details
HOST_Escherichia coli (E. coli) Cow His tag,S tag 100 μg Log in to see 11 to 13 Days
$668.80
Details
HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 11 to 13 Days
$418.00
Details

S100A8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Rat (Rattus) ,

Mouse (Murine)

Top referenced S100A8 Proteins

  1. Human S100A8 Protein expressed in Wheat germ - ABIN1319072 : Maiseyeu, Badgeley, Kampfrath, Mihai, Deiuliis, Liu, Sun, Parthasarathy, Simon, Croce, Rajagopalan: In vivo targeting of inflammation-associated myeloid-related protein 8/14 via gadolinium immunonanoparticles. in Arteriosclerosis, thrombosis, and vascular biology 2012 (PubMed)
    Show all 5 references for ABIN1319072

  2. Mouse (Murine) S100A8 Protein expressed in Escherichia coli (E. coli) - ABIN667469 : Kerkhoff, Klempt, Sorg: Novel insights into structure and function of MRP8 (S100A8) and MRP14 (S100A9). in Biochimica et biophysica acta 1999 (PubMed)
    Show all 2 references for ABIN667469

More Proteins for S100 Calcium Binding Protein A8 (S100A8) Interaction Partners

Horse (Equine) S100 Calcium Binding Protein A8 (S100A8) interaction partners

  1. Calprotectin expression in laminar epidermis occurs after extravasation of leukocytes indicating that leukocyte emigration may be an initiating factor in laminar epithelial stress and inflammation in black walnut extract-induced laminitis.

Human S100 Calcium Binding Protein A8 (S100A8) interaction partners

  1. Data suggest up-regulation of pro-inflammatory molecules TLR9 (show TLR9 Proteins), S100A8, and IL-8 (show IL8 Proteins) plus lower levels of CD11b (show ITGAM Proteins)+ CD33 (show CD33 Proteins)+ myeloid cells may be involved in impairment of wound healing in type 2 diabetes leading to chronic ulcers, such as diabetic foot ulcers.

  2. Elevated expression of MRP8/14 are associated with poor prognosis in lupus nephritis.

  3. BBP (show TP53BP2 Proteins) exposure also increased tumor infiltrating myeloid-derived suppressor cell (MDSC) secretion of S100A8/A9, thereby exacerbating the resistance of breast cancer to doxorubicin with cyclophosphamide

  4. The f (show RPS14 Proteins)requency of S100A8+ cells in del(5q) myelodysplastic syndrome human bone marrow positively correlates with disease severity.

  5. Treg cells suppress the activity of cytotoxic T cells, which kill malaria parasites; therefore, the up-regulation of S100A8 in malaria patients may contribute to pathogen immune escape or tolerance.

  6. Oxidative stress associated with inflammation in cystic fibrosis will stop metal sequestration by calprotectin.

  7. results demonstrate the functional and mechanistic interplays between CD69 (show CD69 Proteins) and S100A8/S100A9 (show S100A9 Proteins) in supporting Treg-cell differentiation

  8. Serum S100A8 and S100A9 (show S100A9 Proteins) Enhance Innate Immune Responses in the Pathogenesis of Baker's Asthma

  9. High S100A8 expression is associated with Refractory Lupus Nephritis.

  10. Alarmins S100A8/S100A9 (show S100A9 Proteins) aggravate osteophyte formation in experimental osteoarthritis and predict osteophyte progression in early human symptomatic osteoarthritis.

Pig (Porcine) S100 Calcium Binding Protein A8 (S100A8) interaction partners

  1. Study verified porcine calprotectin (S100A8/A9) expression at the protein level in multiple Haemophilus parasuis infected tissues and explored their molecular characterization.

Cow (Bovine) S100 Calcium Binding Protein A8 (S100A8) interaction partners

  1. Data suggest that up-regulation of S100A8 and S100A9 (show S100A9 Proteins) is a key component of early endometrial response to uterine involution in the post-partum period and to prevent chronic endometritis/uterine inflammation; up-regulation can be influenced by diet.

Mouse (Murine) S100 Calcium Binding Protein A8 (S100A8) interaction partners

  1. TLR4 (show TLR4 Proteins), TLR2 also contributed to Mrp8-induced inflammatory response and tolerance.

  2. S100A8 appears to play a crucial role in the activation of the TLR4 (show TLR4 Proteins)/MD-2 (show LY96 Proteins) pathway and the promotion of a tumor growth-enhancing immune microenvironment.

  3. Rps14 (show RPS14 Proteins) haploinsufficiency in del(5q) myelodysplastic syndrome is linked to activation of the innate immune system and induction of S100A8-S100A9 (show S100A9 Proteins) expression, leading to a p53 (show TP53 Proteins)-dependent erythroid differentiation defect.

  4. S100A8 is primarily produced from CXCR2 (show CXCR2 Proteins)-expressing CD11b (show ITGAM Proteins)(+)Gr-1 (show GSR Proteins)(high) cells, and it upregulates TNF-alpha (show TNF Proteins) production in CD11b (show ITGAM Proteins)(+)F4/80(+) cells through cellular cross-talk, which is an important mechanism in the development of Nonalcoholic fatty liver disease

  5. Alarmins S100A8/S100A9 (show S100A9 Proteins) aggravate osteophyte formation in experimental osteoarthritis and predict osteophyte progression in early human symptomatic osteoarthritis.

  6. This study identified Mrp8/14 and TLR4 (show TLR4 Proteins) as important modulators of the leukocyte recruitment cascade during inflammation via integrin beta2.

  7. Inflammation-induced S100A8 promotes colorectal tumorigenesis by acting upstream to activate the Akt1 (show AKT1 Proteins)-Smad5 (show SMAD5 Proteins)-Id3 (show ID3 Proteins) axis.

  8. Data shows that S100A8/A9 plays a critical role during glomerulonephritis, exerting and amplifying autocrine and paracrine proinflammatory effects on bone marrow-derived macrophages, renal endothelial cells, and mesangial cells.

  9. S100A8 could be a chemokine (show CCL1 Proteins) of oocyte origin, which attracts ovarian somatic cells to form the primordial follicles.

  10. expression of S100A8 in the lungs may facilitate recruitment of MDSC, which may in turn aid in establishing a metastatic niche capable of suppressing a localized immune response.

S100A8 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis.

Gene names and symbols associated with S100A8

  • S100 calcium binding protein A8 (S100A8)
  • S100 calcium binding protein A8 (S100a8)
  • S100 calcium binding protein A8 (calgranulin A) (S100a8)
  • 60B8Ag protein
  • AI323541 protein
  • B8Ag protein
  • Caga protein
  • CFAg protein
  • CGLA protein
  • CP-10 protein
  • L1Ag protein
  • MA387 protein
  • MIF protein
  • Mrp8 protein
  • NIF protein
  • p8 protein
  • S100A8 protein

Protein level used designations for S100A8

S100 calcium binding protein A8 , MRP-8 , S100 calcium-binding protein A8 (calgranulin A) , calgranulin A , calgranulin-A , calprotectin L1L subunit , cystic fibrosis antigen , leukocyte L1 complex light chain , migration inhibitory factor-related protein 8 , protein S100-A8 , urinary stone protein band A , S100 calcium binding protein A8 (calgranulin A) , p8 , calprotectin , BEE11 , P7 , S100 calcium-binding protein A8 , neutrophil cytosolic 7 kDa protein , chemotactic S100 protein , chemotactic cytokine CP-10 , pro-inflammatory S100 cytokine

GENE ID SPECIES
457319 Pan troglodytes
714740 Macaca mulatta
100294529 Equus caballus
6279 Homo sapiens
116547 Rattus norvegicus
100735514 Cavia porcellus
100127488 Sus scrofa
616818 Bos taurus
490461 Canis lupus familiaris
101104026 Ovis aries
20201 Mus musculus
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