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SATB2 encodes a DNA binding protein that specifically binds nuclear matrix attachment regions. Additionally we are shipping SATB2 Antibodies (75) and many more products for this protein.
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Human SATB2 Protein expressed in Wheat germ - ABIN2752928
Nodin, Johannesson, Wangefjord, OConnor, Lindquist, Uhlén, Jirström, Eberhard: Molecular correlates and prognostic significance of SATB1 expression in colorectal cancer. in Diagnostic pathology 2012
Ovarian tumors with mucinous or endometrioid features that express SATB2 are unlikely to be of primary ovarian origin and more likely to be of colorectal/appendiceal origin.
SATB2 expression increased anchorage-independent growth and cell migration in human bronchial epithelial cells
Data suggest that MIRN-33a-5p is highly induced by TNFa (show TNF Proteins) and BMP-2 (show BMP2 Proteins) in bone marrow stromal cells; anti-osteogenic TNFa (show TNF Proteins) down-regulates SATB2 expression indirectly; pro-osteogenic BMP-2 (show BMP2 Proteins) up-regulates SATB2 expression directly.
SATB2 is a sensitive marker for hindgut well-differentiated neuroendocrine tumors though it is not entirely specific.
We found that IGFBP6 (show IGFBP6 Proteins) and SATB2 were significantly down-regulated in HIV-infected CEM*174 cells and 3 different cohorts of HIV/AIDS patients while their promoters were predominantly hyper-methylated compared with normal controls.
data suggest that SATB2 functions as a tumor suppressor in the development and progression of clear cell renal cell carcinoma (show MOK Proteins)
Immunohistochemical expression of SATB1 (show SATB1 Proteins) and SATB2 was analysed in tissue microarrays with primary tumours and a subset of paired lymph node metastases from 175 patients operated with pancreaticoduodenectomy for periampullary adenocarcinoma.
SATB2 is a direct target of miR (show MLXIP Proteins)-211. SATB2 expression was upregulated in hepatocellular cancer tissues and cell lines. SATB2 rescued the miR (show MLXIP Proteins)-211-mediated inhibition of cell invasion and proliferation.
We provide supporting evidence that analysis for deletions or point mutations in SATB2 should be considered in children with intellectual disability and severely impaired speech, cleft or high palate, teeth abnormalities, and osteopenia.
We here report on a girl with intellectual disability, nearly absent speech and suspected hypodontia who was shown to carry an intragenic SATB2 tandem duplication hypothesized to lead to haploinsufficiency of SATB2.
Data show that Satb2 is required by both callosal projection neurons and subcerebral projection neurons for proper differentiation and axon pathfinding.
Satb2 and Fezf2 (show FEZF2 Proteins) regulation promotes subcerebral projection neuron identity in the developing cerebral cortex
Satb2 may also be related to the establishment of species-specific neuropeptide co-phenotypes during postnatal development.
Target genes of miR (show MLXIP Proteins)-27a ware significantly up-regulated in Satb2-overexpressing cells.
A comprehensive overview of Satb2 expression in the adult mouse brain.
The Satb2 proteins are dispensable for X chromosome inactivation in mice.
the CB(1 (show CNR1 Proteins)) receptor contributes to the generation of deep-layer cortical neurons by coupling endocannabinoid signals from the neurogenic niche to the intrinsic proneurogenic Ctip2/Satb2 axis
Our results indicate a cell autonomous and non-cell autonomous role for Satb2 in regulating the adhesive and/or repulsive properties of cerebral pyramidal neurons.
Genetic evidence obtained in the mouse confirmed the importance of SATB2 regulation by miR (show MLXIP Proteins)-34b/c
SATB2 may play a crucial role in protecting against oxidative stress-induced (show SQSTM1 Proteins) osteoblast apoptosis.
This gene encodes a DNA binding protein that specifically binds nuclear matrix attachment regions. The encoded protein is involved in transcription regulation and chromatin remodeling. Defects in this gene are associated with isolated cleft palate and mental retardation. Alternate splicing results in multiple transcript variants that encode the same protein.
DNA-binding protein SATB2
, special AT-rich sequence-binding protein 2
, special AT-rich sequence binding protein
, SATB homeobox 2
, special AT-rich sequence binding protein 2
, SATB family member 2
, KIAA1034-like DNA binding protein
, two cut domains-containing homeodomain protein