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SATB2 encodes a DNA binding protein that specifically binds nuclear matrix attachment regions. Additionally we are shipping SATB2 Antibodies (92) and many more products for this protein.
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Human SATB2 Protein expressed in Wheat germ - ABIN2752928
Nodin, Johannesson, Wangefjord, OConnor, Lindquist, Uhlén, Jirström, Eberhard: Molecular correlates and prognostic significance of SATB1 expression in colorectal cancer. in Diagnostic pathology 2012
These results strongly suggest that SATB2 prevents induction of EMT (show ITK Proteins) by suppressing expression of EMT (show ITK Proteins)-inducing transcription factors in NSCLC cells.
We describe here the identification of a de novo SATB2 point mutation in twin boys with cleft soft palate, dental anomalies, and development delay and compare the clinical presentation of SATB2 point mutation patients reported to date.
our data reveal that SATB2 in alveolar bone mesenchymal stem cells (AB-BMSCs) associates with their age-related properties, and prevents AB-BMSCs senescence via maintaining Nanog expression.
SATB2 is frequently expressed in appendiceal mucinous neoplasms. In the context of a mucinous neoplasm involving the ovary, any SATB2 positivity should raise the possibility of appendiceal origin.
our results strongly indicate that the crosstalk between p38 (show CRK Proteins) and Akt (show AKT1 Proteins) pathways can determine special AT-rich sequence-binding protein 2 expression and epithelial character of non-small-cell lung carcinoma cells
SATB2 immunohistochemistry is not useful in supporting urothelial versus gastrointestinal or endocervical origin in the differential diagnosis of glandular lesions of the bladder/urinary tract.
we report a exon frameshift mutation in SATB2 in a 15-year-old patient with cleft palate, apparent ID, mild facial dysmorphism, and low weight with additional features of osteoporosis, fractures, progressive tibial bowing, and scoliosis. it provides further evidence of a single-nucleotide, potentially dominant-negative SATB2 allele in association with phenotypes beyond those typically associated with deletion of the gene
Indicate that beta-catenin (show CTNNB1 Proteins) and SATB2 are useful immunohistochemical markers for differentiating between pulmonary enteric adenocarcinoma and metastatic colorectal carcinoma.
SATB2 can directly bind to the regulatory elements in the genetic loci of several stem cell markers and consequently inhibit the progression of CRC (show CALR Proteins) by negatively regulating stemness of CRC (show CALR Proteins) cells
miR (show MLXIP Proteins)-599 directly binds to the 3'untranslated region of SATB2, and western blotting showed that miR (show MLXIP Proteins)-599 suppresses the expression of SATB2 at the protein level. This study indicates that miR (show MLXIP Proteins)-599 promotes proliferation and invasion of non-small cell lung cancer cell lines via SATB2.
Together, these findings demonstrate that Satb2 is critically involved in long-term plasticity processes in the adult forebrain that underlie the consolidation and stabilization of context-linked memory.
Satb2 is a genetic determinant that mediates proper circuit development in a core sensory-to-motor spinal network.
Data indicate two special AT-rich sequence-binding protein 2 (SATB2) sequence variants in two unrelated patients presenting with Rett-like phenotypes.
results suggest that expression of Sp7 (show SP7 Proteins) during the early stage of Satb2-induced osteogenic differentiation of BMSCs is regulated by miR (show MLXIP Proteins)-27a.
Data show that Satb2 is required by both callosal projection neurons and subcerebral projection neurons for proper differentiation and axon pathfinding.
Satb2 and Fezf2 (show FEZF2 Proteins) regulation promotes subcerebral projection neuron identity in the developing cerebral cortex
Satb2 may also be related to the establishment of species-specific neuropeptide co-phenotypes during postnatal development.
Target genes of miR (show MLXIP Proteins)-27a ware significantly up-regulated in Satb2-overexpressing cells.
A comprehensive overview of Satb2 expression in the adult mouse brain.
The Satb2 proteins are dispensable for X chromosome inactivation in mice.
This gene encodes a DNA binding protein that specifically binds nuclear matrix attachment regions. The encoded protein is involved in transcription regulation and chromatin remodeling. Defects in this gene are associated with isolated cleft palate and mental retardation. Alternate splicing results in multiple transcript variants that encode the same protein.
DNA-binding protein SATB2
, special AT-rich sequence-binding protein 2
, special AT-rich sequence binding protein
, SATB homeobox 2
, special AT-rich sequence binding protein 2
, SATB family member 2
, KIAA1034-like DNA binding protein
, two cut domains-containing homeodomain protein