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STIL encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. Additionally we are shipping and many more products for this protein.
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data provide evidence for novel functions of the human oncogene (show RAB1A Antibodies) Stil in neural toxic susceptibility.
The authors suggest that the STIL-coiled-coil region/PLK4 (show PLK4 Antibodies) interaction mediates PLK4 (show PLK4 Antibodies) activation as well as stabilization of centriolar PLK4 (show PLK4 Antibodies) and plays a key role in centriole duplication.
The STIL p.Gly717Glu mutation was not able to fully restore the centriole duplication failure following depletion of endogenous STIL protein indicating the deleterious role of the mutation.
Negative feedback by centriolar STIL regulates bimodal centriolar distribution of Plk4 (show PLK4 Antibodies) and seemingly restricts occurrence of procentriole formation to one site on each parental centriole.
studies provide the first structural insight into how the malfunction of centriole proteins results in human disease and also reveal that the CPAP (show CENPJ Antibodies)-STIL interaction constitutes a conserved key step in centriole biogenesis
STIL mutation causes autosomal recessive microcephalic lobar holoprosencephaly.
propose that centriole amplification triggered by STIL stabilization is the underlying cause of microcephaly in human patients with corresponding STIL mutations
results provide direct evidence for the involvement of Stil in dopaminergic cell proliferation
A novel function for Stil protein is neural progenitor cell proliferation but not neural differentiation.
Identification of a novel STIL mutation in a family with primary microcephaly.
STIL(-/-) mouse embryos do not contain centrioles or primary cilia, suggesting that these organelles are not essential for mammalian development until mid gestation.
Stil protein regulates centrosome integrity and mitosis through suppression of Chfr.
cloned a mouse homolog of the human SIL promoter
Scl (show TAL1 Antibodies) is required for the programming of adult haemangioblasts.
decreased expression of Stil resulted in increased toxic susceptibility of retinal dopaminergic cells to 6-hydroxydopamine
Scl (show TAL1 Antibodies)/Lmo2 (show LMO2 Antibodies) complex does not appear to autoregulate, as neither gene's expression is affected by depletion of the other
These data, taken together, identify SIL as a novel, vertebrate-specific regulator of mitotic spindle assembly.
This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene.
Tal1 interrupting locus
, SCL-interrupting locus protein
, TAL-1-interrupting locus protein
, SCL-interrupting locus protein homolog
, TAL1 (SCL) interrupting locus like