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SEC63 Homolog (S. Cerevisiae) (SEC63) ELISA Kits

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Additionally we are shipping SEC63 Antibodies (33) and SEC63 Proteins (7) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human SEC63 SEC63 11231 Q9UGP8
Anti-Rat SEC63 SEC63 309858  
Anti-Mouse SEC63 SEC63 140740 Q8VHE0
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More ELISA Kits for SEC63 Interaction Partners

Human SEC63 Homolog (S. Cerevisiae) (SEC63) interaction partners

  1. a SEC63 germline mutation may play a role in cyst formation in polycystic liver disease

  2. Phosphorylation of Sec63 by CK2 (show CSNK2A1 ELISA Kits) enhanced its binding to Sec62 (show TLOC1 ELISA Kits)

  3. Sec63 may perform a substrate-selective quantity control function during cotranslational endoplasmic reticulum import.

  4. Silencing the human SEC63 genes inhibits transport of only a subset of signal-peptide-containing precursor proteins to endoplasmic reticulum.

  5. identified nucleoredoxin (show NXN ELISA Kits) as an interaction partner of Sec63; characterized this interaction; Sec63 is linked to the Wnt (show WNT2 ELISA Kits) signaling pathways and this interaction may be the reason why mutations in SEC63 can lead to polycystic liver disease

  6. identified a total of 26 novel mutations in PRKCSH (show PRKCSH ELISA Kits) (n = 14) and SEC63 (n = 12), including four splice site mutations, eight insertions/ deletions, six non-sense mutations, and eight missense mutations

  7. Mutations in SEC63 cause autosomal dominant polycystic liver disease, suggesting a role for cotranslational protein-processing pathways in maintaining epithelial luminal structure and implicating noncilial ER proteins in human polycystic disease.

  8. Sec63p expression was observed in all cyst epithelia regardless of mutational state. And, Cystogenesis in SEC63-associated PCLD (show PRKCSH ELISA Kits) occurs via a different mechanism.

Zebrafish SEC63 Homolog (S. Cerevisiae) (SEC63) interaction partners

  1. disruption of sec63 leads to abnormalities in myelinating glia in both the central and peripheral nervous systems

Mouse (Murine) SEC63 Homolog (S. Cerevisiae) (SEC63) interaction partners

  1. SEC63 function regulates IRE1alpha (show ERN1 ELISA Kits)/XBP1 (show XBP1 ELISA Kits) activation. SEC63 and XBP1 (show XBP1 ELISA Kits) are required for GPS (show NBEAL2 ELISA Kits) cleavage and maturation of PC1 (show PCSK1 ELISA Kits), protecting against polycystic disease.

  2. The pro-carcinogenic growth behavior of hepatocytes with low SEC63 expression in the murine model indicates a potential role for SEC63 in hepatocarcinogenesis in general.

  3. Knockout of the murine Sec63 gene inhibits transport of precursor proteins into the endoplasmic reticulum.

  4. SEC63 gene expression is up-regulated and predominantly localized in mouse decidual cells during days 5-8 of pregnancy.

SEC63 Antigen Profile

Antigen Summary

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER.

Gene names and symbols associated with SEC63

  • translocation protein SEC63 homolog (LOC100159107) antibody
  • SEC63 homolog (sec63) antibody
  • SEC63 homolog (S. cerevisiae) (SEC63) antibody
  • SEC63 homolog (S. cerevisiae) (Sec63) antibody
  • SEC63-like (S. cerevisiae) (sec63) antibody
  • SEC63-like (S. cerevisiae) (Sec63) antibody
  • 5730478J10Rik antibody
  • AI649014 antibody
  • AW319215 antibody
  • DNAJC23 antibody
  • ERdj2 antibody
  • PRO2507 antibody
  • SEC63-like antibody
  • SEC63L antibody
  • zgc:92718 antibody

Protein level used designations for SEC63

translocation protein SEC63 homolog , SEC63-like protein

100159107 Acyrthosiphon pisum
495416 Xenopus laevis
421774 Gallus gallus
11231 Homo sapiens
475016 Canis lupus familiaris
541040 Bos taurus
100328696 Oryctolagus cuniculus
309858 Rattus norvegicus
436861 Danio rerio
140740 Mus musculus
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