You are viewing an incomplete version of our website. Please click to reload the website as full version.

anti-SECIS Binding Protein 2 (SECISBP2) Antibodies

The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. Additionally we are shipping SECIS Binding Protein 2 Kits (2) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SECISBP2 75420  
SECISBP2 79048 Q96T21
SECISBP2 79049 Q9QX72
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-SECIS Binding Protein 2 Antibodies at antibodies-online.com

Showing 10 out of 61 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Goat Un-conjugated EIA, IF, IHC (p), IP, WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated EIA, WB western blot analysis of SECISBP2 Antibody (Center) Cat.-No AP53835PU-N in HL-60 cell line lysates (35ug/lane). This demonstrates the SECISBP2 antibody detected the SECISBP2 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB SECISBP2 Antibody (Center) (ABIN658828) western blot analysis in HL-60 cell line lysates (35 µg/lane). This demonstrates the SECISBP2 antibody detected the SECISBP2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated IP, IHC, ELISA, WB ABIN185714 staining of HFF cell lysate with B) 100nM siRNA or A) control siRNA. Detected by chemiluminescence. Data kindly provided by Laura Papp and Kum Kum Khanna, Brisbane, Australia. ABIN185714 (3µg/ml) staining of paraffin embedded Human Testis. Microwaved antigen retrieval with Tris/EDTA buffer pH9, HRP-staining. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated DB, WB 50 μg Log in to see 7 to 9 Days
$285.71
Details
Human Goat Un-conjugated ICC, IF, IP, IHC, ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 14 Days
$527.15
Details
Human Goat Un-conjugated ELISA, WB 100 μg Log in to see 8 to 10 Days
$595.83
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details

SECISBP2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine)
,

Human , ,
, ,
,
, , , , ,
Rat (Rattus)
,

Top referenced anti-SECIS Binding Protein 2 Antibodies

  1. Human Polyclonal SECISBP2 Primary Antibody for IP, IHC - ABIN185714 : Papp, Lu, Striebel, Kennedy, Holmgren, Khanna: The redox state of SECIS binding protein 2 controls its localization and selenocysteine incorporation function. in Molecular and cellular biology 2006 (PubMed)
    Show all 3 references for ABIN185714

  2. Human Polyclonal SECISBP2 Primary Antibody for EIA, WB - ABIN954708 : Méplan, Hughes, Pardini, Naccarati, Soucek, Vodickova, Hlavatá, Vrána, Vodicka, Hesketh: Genetic variants in selenoprotein genes increase risk of colorectal cancer. in Carcinogenesis 2010 (PubMed)
    Show all 2 references for ABIN954708

  3. Cow (Bovine) Polyclonal SECISBP2 Primary Antibody for EIA, IF - ABIN374739 : Papp, Wang, Kennedy, Boucher, Zhang, Gladyshev, Singh, Khanna: Functional characterization of alternatively spliced human SECISBP2 transcript variants. in Nucleic acids research 2008 (PubMed)

More Antibodies against SECIS Binding Protein 2 Interaction Partners

Mouse (Murine) SECIS Binding Protein 2 (SECISBP2) interaction partners

  1. Secisbp2 is essential for embryonic development and enhances selenoprotein expression.

  2. SBP2/SECIS complex activates eEFSec by directing functional interactions between Domain IV and the ribosome to promote Sec-tRNA(Sec) binding and accommodation into the ribosomal A-site

  3. Selenocysteine insertion sequence (SECIS)-binding protein 2 alters conformational dynamics of residues involved in tRNA accommodation in 80 S ribosomes.

Fruit Fly (Drosophila melanogaster) SECIS Binding Protein 2 (SECISBP2) interaction partners

  1. Swapping only five amino acids between dSBP2 and human SBP2 in the K-rich domain conferred reversed SECIS-binding properties to the proteins, thus unveiling an important sequence for form 1 binding.

Human SECIS Binding Protein 2 (SECISBP2) interaction partners

  1. SBP2 makes direct contacts with a discrete region of the human 28S rRNA.

  2. The patient showed typical symptoms of SBP2 deficiency, and novel compound heterozygous mutations were identified in SBP2 (p.M515fsX563/p.Q79X).

  3. Selenocysteine insertion sequence (SECIS)-binding protein 2 alters conformational dynamics of residues involved in tRNA accommodation in 80 S ribosomes.

  4. Describe subjects with compound heterozygous defects in the SECISBP2 gene. These individuals have reduced synthesis of most of the 25 known human selenoproteins, resulting in a complex phenotype.

  5. Results demonstrate that SECIS-binding protein 2 is required for protection against reactive oxygen species-induced cellular damage and cell survival.

  6. In addition to identifying key amino acids for SECIS recognition by SBP2, our findings led to the proposal that some of the recognition principles governing the 15.5 kD-U4 snRNA interaction must be similar in the SBP2-SECIS RNA complex

  7. Oxidative stress induces nuclear accumulation of SBP2 via oxidation of cysteine residues within a redox-sensitive cysteine-rich domain.

  8. Data suggest that SBP2 is a major determinant in dictating the hierarchy of selenoprotein synthesis via differential selenoprotein mRNA translation and sensitivity to nonsense-mediated decay.

  9. SECIS binding induces a conformational change in SBP2 that recruits eEFSec (show EEFSEC Antibodies), which in concert with the Sec incorporation domain gains access to the ribosomal A site

  10. A report of a complex splicing pattern in the 5'-region of human SECISBP2, wherein at least eight splice variants encode five isoforms with varying N-terminal sequence.

SECIS Binding Protein 2 (SECISBP2) Antigen Profile

Protein Summary

The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism.

Gene names and symbols associated with SECISBP2

  • SECIS binding protein 2 (Secisbp2) antibody
  • SECIS-binding protein 2 (Sbp2) antibody
  • SECIS binding protein 2 (SECISBP2) antibody
  • SECIS binding protein 2 (secisbp2) antibody
  • 2210413N07Rik antibody
  • 2810012K13Rik antibody
  • CG7066 antibody
  • DKFZp459F1026 antibody
  • Dmel\\CG7066 antibody
  • Sbp2 antibody

Protein level used designations for SECISBP2

selenocysteine insertion sequence-binding protein 2 , CG7066-PA , SECIS binding protein 2 , Sbp2-PA , selenocysteine insertion sequence-binding protein 2-like , SECIS-binding protein 2

GENE ID SPECIES
75420 Mus musculus
38934 Drosophila melanogaster
426815 Gallus gallus
100036714 Xenopus (Silurana) tropicalis
100173231 Pongo abelii
464583 Pan troglodytes
697442 Macaca mulatta
100470097 Ailuropoda melanoleuca
100590393 Nomascus leucogenys
79048 Homo sapiens
476351 Canis lupus familiaris
100153797 Sus scrofa
511202 Bos taurus
79049 Rattus norvegicus
Selected quality suppliers for anti-SECIS Binding Protein 2 (SECISBP2) Antibodies
Did you look for something else?