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The protein encoded by SERTAD3 was identified in a yeast two-hybrid assay employing the second subunit of human replication protein A as bait. Additionally we are shipping SERTAD3 Antibodies (10) and SERTAD3 Proteins (4) and many more products for this protein.
Transduction of stably expressed human SERTAD3 induces cell transformation in vitro and tumor formation in mice via a transcription factor E2F-dependent mechanism.
The protein encoded by this gene was identified in a yeast two-hybrid assay employing the second subunit of human replication protein A as bait. It is localized to the nucleus and its expression is significantly higher in cancer cell lines compared to normal cell lines. This protein has also been shown to be a strong transcriptional co-activator. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified.
, SERTA domain-containing protein 3
, replication protein-binding trans-activator
, replication protein binding trans-activator