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SET Domain, Bifurcated 1 (SETDB1) ELISA Kits

SETDB1 encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. Additionally we are shipping SETDB1 Antibodies (97) and SETDB1 Proteins (7) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Rat SETDB1 SETDB1 689883  
Anti-Human SETDB1 SETDB1 9869 Q15047
Anti-Mouse SETDB1 SETDB1 84505  
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More ELISA Kits for SETDB1 Interaction Partners

Cow (Bovine) SET Domain, Bifurcated 1 (SETDB1) interaction partners

  1. SETDB1 is essential for the earliest events in lineage specification in the bovine blastocyst.

Human SET Domain, Bifurcated 1 (SETDB1) interaction partners

  1. results indicate that ATF7IP (show ATF7IP ELISA Kits) does not directly modulate SETDB1 catalytic activity, suggesting alternate roles, such as affecting cellular localization or mediating interaction with additional binding partners.

  2. SETDB1 is an oncogene (show RAB1A ELISA Kits) that is frequently up-regulated in human HCCs (show HCCS ELISA Kits); the multiplicity of SETDB1 activating mechanisms at the chromosomal, transcriptional, and posttranscriptional levels together facilitates SETDB1 up-regulation in human HCC (show FAM126A ELISA Kits)

  3. regulates cancer cell growth via methylation of p53 (show TP53 ELISA Kits)

  4. SETDB1, localized in the nucleus, might undergo degradation by the proteasome and be exported to the cytosol, resulting in its detection mainly in the cytosol.

  5. Exogenous expression of MyoD (show MYOD1 ELISA Kits) reversed transcriptional repression of MyoD (show MYOD1 ELISA Kits) promoter-driven lucif-erase reporter by Setdb1 shRNA and rescued myogenic differentiation of C2C12 myoblast cells depleted of endogenous Setdb1.

  6. Authors demonstrate that a KMT1E-containing complex directly interacts with the FcgammaRIIb promoter and that histone H3 (show HIST3H3 ELISA Kits) at lysine 9 tri (show VANGL2 ELISA Kits)-methylation at this promoter is dependent on Setdb1

  7. MiR-7, inhibited indirectly by lincRNA HOTAIR, directly inhibits SETDB1 and reverses the Epithelial-mesenchymal transition of breast cancer stem cells by down regulating the STAT3 (show STAT3 ELISA Kits) pathway

  8. Report elevated levels of SETDB1 in non-small lung cancers, associated with neoplasm grading and tumor growth.

  9. This observation suggests that the ZNF274 (show ZNF274 ELISA Kits)/SETDB1 complex bound to the SNORD116 cluster may protect the Prader-Willi syndrome induced pluripotent cells from DNA demethylation during early development.

  10. Together, our findings defined an essential role for the KMT1E/SMAD2 (show SMAD2 ELISA Kits)/3 repressor complex in TGFbeta (show TGFB1 ELISA Kits)-mediated lung cancer metastasis.

Mouse (Murine) SET Domain, Bifurcated 1 (SETDB1) interaction partners

  1. Setdb1 is a maternal-effect (show NLRP5 ELISA Kits) gene that controls meiotic progression and is essential for early embryogenesis. Setdb1 is an important regulator of Cdc14b (show CDC14B ELISA Kits).

  2. The currently identified reciprocal action between SETDB1 and PRC2 reveals a novel mechanism underlying ES cell pluripotency and differentiation regulation.

  3. regulates cancer cell growth via methylation of p53 (show TP53 ELISA Kits)

  4. Data show that histone methyltransferase SETDB1 functions as an epigenetic repressor of all endogenous retroviruses (ERVs) in B lymphocytes.

  5. these findings reveal a novel regulatory hierarchy governing SETDB1 recruitment and in turn, transcriptional silencing in mESCs.

  6. ESET regulated spermatogonial stem cells apoptosis.

  7. SETDB1 is an essential guardian against proviral expression prior to the onset of de novo DNA methylation (show HELLS ELISA Kits) in the germline

  8. Setdb1 promotes the persistence of DNA methylation (show HELLS ELISA Kits) in embryonic stem cells, likely reflecting a mechanism by which DNA methylation (show HELLS ELISA Kits) is maintained at LTR retrotransposons and imprinted genes during developmental stages when DNA methylation (show HELLS ELISA Kits) is reprogrammed.

  9. ESET is a critical regulator of osteoblast differentiation during bone development.

  10. presume that the cytoplasmic retention of over-expressed Setdb1 occurs as part of a regulatory mechanism to set a tight limit on the nuclear activity of Setdb1, whose excess activity might result in random and haphazard chromatin modifications that cause globally aberrant gene expression

SETDB1 Antigen Profile

Antigen Summary

This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.

Gene names and symbols associated with SETDB1

  • SET domain, bifurcated 1 (Setdb1) antibody
  • SET domain, bifurcated 1 (SETDB1) antibody
  • SET domain, bifurcated 1a (setdb1a) antibody
  • SET domain, bifurcated 1 (setdb1) antibody
  • AU022152 antibody
  • ESET antibody
  • fc07d03 antibody
  • H3-K9-HMTase4 antibody
  • KG1T antibody
  • KMT1E antibody
  • mKIAA0067 antibody
  • NV10069 antibody
  • SETDB1 antibody
  • si:ch211-81a5.6 antibody
  • TDRD21 antibody
  • wu:fc07d03 antibody

Protein level used designations for SETDB1

histone-lysine N-methyltransferase SETDB1 , SET domain, bifurcated 1 , histone-lysine N-methyltransferase SETDB1-like , histone-lysine N-methyltransferase SETDB1-A , ERG-associated protein with SET domain , ERG-associated protein with a SET domain, ESET , H3-K9-HMTase 4 , histone H3-K9 methyltransferase 4 , histone-lysine N-methyltransferase, H3lysine-9 specific 4 , lysine N-methyltransferase 1E , tudor domain containing 21 , SET domain ERG-associated histone methyltransferase

GENE ID SPECIES
689883 Rattus norvegicus
395847 Gallus gallus
469481 Pan troglodytes
716141 Macaca mulatta
100120014 Nasonia vitripennis
100138100 Bos taurus
100157920 Sus scrofa
100411734 Callithrix jacchus
100461671 Pongo abelii
100482250 Ailuropoda melanoleuca
553292 Danio rerio
9869 Homo sapiens
84505 Mus musculus
432147 Xenopus laevis
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