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SET Domain, Bifurcated 1 Proteins (SETDB1)

SETDB1 encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. Additionally we are shipping SETDB1 Antibodies (108) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat SETDB1 SETDB1 689883  
SETDB1 9869 Q15047
SETDB1 84505  
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Top SETDB1 Proteins at

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Baculovirus Human DYKDDDDK Tag Recombinant SETDB1 protein gel. SETDB1 protein was run on an SDS-PAGE gel and stained with Coomassie blue. SETDB1 activity assay. HMT assay measuring the activity of Recombinant SETDB1. Activity was detected by fluorography. 20 μg Log in to see 1 to 2 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days

SETDB1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

More Proteins for SET Domain, Bifurcated 1 (SETDB1) Interaction Partners

Cow (Bovine) SET Domain, Bifurcated 1 (SETDB1) interaction partners

  1. SETDB1 is essential for the earliest events in lineage specification in the bovine blastocyst.

Human SET Domain, Bifurcated 1 (SETDB1) interaction partners

  1. These results suggest that SETDB1- mediated FosB (show FOSB Proteins) expression is a common molecular phenomenon, and might be a novel pathway responsible for the increase in cell proliferation that frequently occurs during anticancer drug therapy.

  2. SETDB1 mutations are associated with malignant pleural mesotheliomas.

  3. Upon HBV infection, cellular mechanisms involving SETDB1-mediated H3K9me3 and HP1 (show DEFA1 Proteins) induce silencing of HBV cccDNA transcription through modulation of chromatin structure.

  4. The SETDB1 protein was closely associated with the prognosis of prostate cancer (PCa (show FLVCR1 Proteins)). Bioinformatics suggested that SETDB1 might promote PCa (show FLVCR1 Proteins) bone metastasis through the WNT (show WNT2 Proteins) pathway. In conclusion, SETDB1 might be associated with the development of bone metastases from PCa (show FLVCR1 Proteins)

  5. results indicate that ATF7IP does not directly modulate SETDB1 catalytic activity, suggesting alternate roles, such as affecting cellular localization or mediating interaction with additional binding partners.

  6. SETDB1 is an oncogene (show RAB1A Proteins) that is frequently up-regulated in human HCCs (show HCCS Proteins); the multiplicity of SETDB1 activating mechanisms at the chromosomal, transcriptional, and posttranscriptional levels together facilitates SETDB1 up-regulation in human HCC (show FAM126A Proteins)

  7. regulates cancer cell growth via methylation of p53 (show TP53 Proteins)

  8. SETDB1, localized in the nucleus, might undergo degradation by the proteasome and be exported to the cytosol, resulting in its detection mainly in the cytosol.

  9. Exogenous expression of MyoD (show MYOD1 Proteins) reversed transcriptional repression of MyoD (show MYOD1 Proteins) promoter-driven lucif-erase reporter by Setdb1 shRNA and rescued myogenic differentiation of C2C12 myoblast cells depleted of endogenous Setdb1.

  10. Authors demonstrate that a KMT1E-containing complex directly interacts with the FcgammaRIIb promoter and that histone H3 (show HIST3H3 Proteins) at lysine 9 tri (show VANGL2 Proteins)-methylation at this promoter is dependent on Setdb1

Mouse (Murine) SET Domain, Bifurcated 1 (SETDB1) interaction partners

  1. Setdb1 is a maternal-effect gene that controls meiotic progression and is essential for early embryogenesis. Setdb1 is an important regulator of Cdc14b (show CDC14B Proteins).

  2. The currently identified reciprocal action between SETDB1 and PRC2 reveals a novel mechanism underlying ES cell pluripotency and differentiation regulation.

  3. regulates cancer cell growth via methylation of p53 (show TP53 Proteins)

  4. Data show that histone methyltransferase SETDB1 functions as an epigenetic repressor of all endogenous retroviruses (ERVs) in B lymphocytes.

  5. these findings reveal a novel regulatory hierarchy governing SETDB1 recruitment and in turn, transcriptional silencing in mESCs.

  6. ESET regulated spermatogonial stem cells apoptosis.

  7. SETDB1 is an essential guardian against proviral expression prior to the onset of de novo DNA methylation (show HELLS Proteins) in the germline

  8. Setdb1 promotes the persistence of DNA methylation (show HELLS Proteins) in embryonic stem cells, likely reflecting a mechanism by which DNA methylation (show HELLS Proteins) is maintained at LTR retrotransposons and imprinted genes during developmental stages when DNA methylation (show HELLS Proteins) is reprogrammed.

  9. ESET is a critical regulator of osteoblast differentiation during bone development.

  10. presume that the cytoplasmic retention of over-expressed Setdb1 occurs as part of a regulatory mechanism to set a tight limit on the nuclear activity of Setdb1, whose excess activity might result in random and haphazard chromatin modifications that cause globally aberrant gene expression

SETDB1 Protein Profile

Protein Summary

This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.

Gene names and symbols associated with SETDB1

  • SET domain, bifurcated 1 (Setdb1)
  • SET domain, bifurcated 1 (SETDB1)
  • SET domain, bifurcated 1a (setdb1a)
  • SET domain, bifurcated 1 (setdb1)
  • AU022152 protein
  • ESET protein
  • fc07d03 protein
  • H3-K9-HMTase4 protein
  • KG1T protein
  • KMT1E protein
  • mKIAA0067 protein
  • NV10069 protein
  • SETDB1 protein
  • si:ch211-81a5.6 protein
  • TDRD21 protein
  • wu:fc07d03 protein

Protein level used designations for SETDB1

histone-lysine N-methyltransferase SETDB1 , SET domain, bifurcated 1 , histone-lysine N-methyltransferase SETDB1-like , histone-lysine N-methyltransferase SETDB1-A , ERG-associated protein with SET domain , ERG-associated protein with a SET domain, ESET , H3-K9-HMTase 4 , histone H3-K9 methyltransferase 4 , histone-lysine N-methyltransferase, H3lysine-9 specific 4 , lysine N-methyltransferase 1E , tudor domain containing 21 , SET domain ERG-associated histone methyltransferase

689883 Rattus norvegicus
395847 Gallus gallus
469481 Pan troglodytes
716141 Macaca mulatta
100120014 Nasonia vitripennis
100138100 Bos taurus
100157920 Sus scrofa
100411734 Callithrix jacchus
100461671 Pongo abelii
100482250 Ailuropoda melanoleuca
553292 Danio rerio
9869 Homo sapiens
84505 Mus musculus
432147 Xenopus laevis
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