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SETDB1 encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. Additionally we are shipping SETDB1 Proteins (7) and many more products for this protein.
Showing 10 out of 118 products:
Human Polyclonal SETDB1 Primary Antibody for ELISA, IHC - ABIN4353068
Schultz, Ayyanathan, Negorev, Maul, Rauscher: SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. in Genes & development 2002
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Human Polyclonal SETDB1 Primary Antibody for ICC, IF - ABIN4353070
Ceol, Houvras, Jane-Valbuena, Bilodeau, Orlando, Battisti, Fritsch, Lin, Hollmann, Ferré, Bourque, Burke, Turner, Uong, Johnson, Beroukhim, Mermel, Loda, Ait-Si-Ali, Garraway, Young, Zon: The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset. in Nature 2011
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Human Polyclonal SETDB1 Primary Antibody for BP, ChIP - ABIN4353071
Skuland, Ovrevik, Låg, Schwarze, Refsnes: Silica nanoparticles induce cytokine responses in lung epithelial cells through activation of a p38/TACE/TGF-α/EGFR-pathway and NF-κΒ signalling. in Toxicology and applied pharmacology 2014
Human Monoclonal SETDB1 Primary Antibody for ELISA, WB - ABIN967016
Rosendorff, Sakakibara, Lu, Kieff, Xuan, DiBacco, Shi, Shi, Gill: NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression. in Proceedings of the National Academy of Sciences of the United States of America 2006
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Human Monoclonal SETDB1 Primary Antibody for ICC, ELISA - ABIN969394
Gevaert, Staes, Van Damme, De Groot, Hugelier, Demol, Martens, Goethals, Vandekerckhove: Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC. in Proteomics 2005
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Human Polyclonal SETDB1 Primary Antibody for IF (p), IHC (p) - ABIN1387645
Marco, Kisliouk, Tabachnik, Weller, Meiri et al.: DNA CpG Methylation (5-Methylcytosine) and Its Derivative (5-Hydroxymethylcytosine) Alter Histone Posttranslational Modifications at the Pomc Promoter, Affecting the Impact of Perinatal Diet on ... in Diabetes 2016
SETDB1 is essential for the earliest events in lineage specification in the bovine blastocyst.
We identified a list of thirty genes repressed by DeltaNp63 in a SETDB1-dependent manner, whose expression is positively correlated to survival of breast cancer patients. These results suggest that p63 (show RPE65 Antibodies) and SETDB1 expression, together with the repressed genes, may have diagnostic and prognostic potential
these data identify a critical functional role for ATF7IP (show ATF7IP Antibodies) in heterochromatin formation by regulating SETDB1 abundance in the nucleus.
SETDB1 triggers silencing of retrotransposons to inhibit the interferon (show IFNA Antibodies) response in acute myeloid leukemia (show BCL11A Antibodies) cells.
analysis of a 1q21.3 deletion encompassing SETDB1 that provides further support for the role of chromatin modifiers in the etiology of autism spectrum disorder
SETDB1 protein expression was significantly associated with poor survival and was related to TNM (show ODZ1 Antibodies) stage.
SETDB1, a major histone H3K9 methyltransferase is monoubiquitinated at the evolutionarily conserved lysine-867 in its SET-Insertion domain. This ubiquitination is directly catalyzed by UBE2E family of E2 enzymes in an E3-independent manner while the conjugated-ubiquitin (Ub) is protected from active deubiquitination.
These results suggest that the ubiquitination of SETDB1 at lysine 867 controls the expression of its target gene by activating its H3K9 methyltransferase activity.
Authors observed several complementary mechanisms contributing to the upregulation of SETDB1 in HCC (show FAM126A Antibodies) cells. Besides copy number gains at the SETDB1 gene locus at chromosome 1q21 enhanced SETDB1 transcription mediated by the transcription factor SP1 (show SP1 Antibodies) could be detected.
BRCA1 and SETDB1 stand out as the most significant prognostic markers in this group of patients
These results suggest that SETDB1- mediated FosB (show FOSB Antibodies) expression is a common molecular phenomenon, and might be a novel pathway responsible for the increase in cell proliferation that frequently occurs during anticancer drug therapy.
Results identify Setdb1 as a paternal effect gene in the mouse and suggest that epigenetic inheritance may be more likely in individuals with altered levels of epigenetic modifiers.
Setdb1 regulates PTEN (show PTEN Antibodies)/AKT (show AKT1 Antibodies)/FOXO1 (show FOXO1 Antibodies) pathway to inhibit Spermatogonial stem cells apoptosis.
the SETDB1 repressor complex shields neuronal genomes from excess CTCF (show CTCF Antibodies) genome organizer binding and is critically required for structural maintenance of the protocadherin locus topologically associated domain
The results identify Setdb1 as a newly discovered meiotic and embryonic competence factor safeguarding genome integrity at the onset of life.
study identifed ESET as first trimethylated H3K9 histone methyltransferase playing a crucial role in T cell development
Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genes.
SETDB1 maintains silencing of intracisternal A particle, but in the absence of DNMT1 (show DNMT1 Antibodies), prolonged binding of NP95 (show UHRF1 Antibodies) to hemimethylated DNA transiently disrupts SETDB1-dependent H3K9me3 deposition.
Deletion of Setdb1 led to enlarged Meckel's cartilage. Chondrocytes from the Meckel's cartilage of Setdb1 mutant showed increased in size.
Setdb1 is a maternal-effect (show NLRP5 Antibodies) gene that controls meiotic progression and is essential for early embryogenesis. Setdb1 is an important regulator of Cdc14b (show CDC14B Antibodies).
This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.
histone-lysine N-methyltransferase SETDB1
, SET domain, bifurcated 1
, histone-lysine N-methyltransferase SETDB1-like
, histone-lysine N-methyltransferase SETDB1-A
, ERG-associated protein with SET domain
, ERG-associated protein with a SET domain, ESET
, H3-K9-HMTase 4
, histone H3-K9 methyltransferase 4
, histone-lysine N-methyltransferase, H3lysine-9 specific 4
, lysine N-methyltransferase 1E
, tudor domain containing 21
, SET domain ERG-associated histone methyltransferase