anti-SET Domain, Bifurcated 1 (SETDB1) Antibodies

SETDB1 encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. Additionally we are shipping SETDB1 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SETDB1 689883  
SETDB1 9869 Q15047
SETDB1 84505  
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Top anti-SETDB1 Antibodies at antibodies-online.com

Showing 10 out of 117 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Western blot analysis of anti-SETDB1 Pab(ABIN387924) in Ramos cell line lysate (35 µg/lane). SETDB1(arrow) was detected using the purified polyclonal antibody (1:60 dilution). Western blot analysis of SETDB1(arrow) using rabbit polyclonal SETDB1 Antibody (C-term) (ABIN387924). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the SETDB1 gene (Lane 2) (Origene Technologies). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to SETDB1 on HeLa cell (antibody concentration 10 µg/mL). SETDB1 monoclonal antibody (M07), clone 4A3 Western Blot analysis of SETDB1 expression in SW-13. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated BP, ChIP, IP, in vitro, Neut, WB Western Blot: SETDB1 Antibody [NBP2-20321] - Sample (30 ug of whole cell lysate) A: U87-MG 5% SDS PAGE gel, diluted at 1:2000. 0.1 mL Log in to see 8 to 11 Days
$447.56
Details
Human Mouse Un-conjugated ELISA, WB Figure 1: Western blot analysis using SETDB1 mouse mAb against MCF-7 (1) ,T47D (2), HEK293 (3), JURKAT (4), NIH/3T3 (5) and F9 (6) cell lysate. 100 μL Log in to see 2 to 3 Days
$393.80
Details
Human Mouse Un-conjugated ICC, ELISA, WB Figure 1: Immunofluorescence analysis of LOVO cells using SETDB1 mouse mAb (green) . Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. Figure 2: Western blot analysis using SETDB1 mouse mAb against MCF-7 (1) ,T47D (2), HEK293 (3), JURKAT (4), NIH/3T3 (5), F9 (6), RAW246.7 (7) and Cos7 (8) cell lysate. 100 μL Log in to see 2 to 3 Days
$393.80
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: SETDB1 Antibody [NBP1-84790] - Staining of human colon shows strong nuclear, cytoplasmic and membranous positivity in glandular cells. Immunocytochemistry/Immunofluorescence: SETDB1 Antibody [NBP1-84790] - Staining of human cell line A-431 shows positivity in nucleus but not nucleoli, plasma membrane & cytoplasm. 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Human Rabbit Un-conjugated EIA, WB   0.1 mg Log in to see 12 to 15 Days
$411.18
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB   100 μL Log in to see 3 to 7 Days
$295.90
Details

SETDB1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-SETDB1 Antibodies

  1. Human Polyclonal SETDB1 Primary Antibody for ELISA, IHC - ABIN4353068 : Schultz, Ayyanathan, Negorev, Maul, Rauscher: SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. in Genes & development 2002 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal SETDB1 Primary Antibody for ICC, IF - ABIN4353070 : Ceol, Houvras, Jane-Valbuena, Bilodeau, Orlando, Battisti, Fritsch, Lin, Hollmann, Ferré, Bourque, Burke, Turner, Uong, Johnson, Beroukhim, Mermel, Loda, Ait-Si-Ali, Garraway, Young, Zon: The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset. in Nature 2011 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal SETDB1 Primary Antibody for BP, ChIP - ABIN4353071 : Skuland, Ovrevik, Låg, Schwarze, Refsnes: Silica nanoparticles induce cytokine responses in lung epithelial cells through activation of a p38/TACE/TGF-α/EGFR-pathway and NF-κΒ signalling. in Toxicology and applied pharmacology 2014 (PubMed)

  4. Human Monoclonal SETDB1 Primary Antibody for ELISA, WB - ABIN969393 : Gevaert, Staes, Van Damme, De Groot, Hugelier, Demol, Martens, Goethals, Vandekerckhove: Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC. in Proteomics 2005 (PubMed)
    Show all 2 Pubmed References

  5. Human Monoclonal SETDB1 Primary Antibody for ICC, ELISA - ABIN969394 : Rosendorff, Sakakibara, Lu, Kieff, Xuan, DiBacco, Shi, Shi, Gill: NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression. in Proceedings of the National Academy of Sciences of the United States of America 2006 (PubMed)
    Show all 2 Pubmed References

  6. Human Monoclonal SETDB1 Primary Antibody for ELISA, WB - ABIN967016 : Gao, Yu, Bi, Jiang, Cui, Sun, Ma: Akt/PKB interacts with the histone H3 methyltransferase SETDB1 and coordinates to silence gene expression. in Molecular and cellular biochemistry 2007 (PubMed)
    Show all 3 Pubmed References

  7. Human Polyclonal SETDB1 Primary Antibody for IF (p), IHC (p) - ABIN1387645 : Marco, Kisliouk, Tabachnik, Weller, Meiri et al.: DNA CpG Methylation (5-Methylcytosine) and Its Derivative (5-Hydroxymethylcytosine) Alter Histone Posttranslational Modifications at the Pomc Promoter, Affecting the Impact of Perinatal Diet on ... in Diabetes 2016 (PubMed)

More Antibodies against SETDB1 Interaction Partners

Cow (Bovine) SET Domain, Bifurcated 1 (SETDB1) interaction partners

  1. SETDB1 is essential for the earliest events in lineage specification in the bovine blastocyst.

Human SET Domain, Bifurcated 1 (SETDB1) interaction partners

  1. SETDB1, a major histone H3K9 methyltransferase is monoubiquitinated at the evolutionarily conserved lysine-867 in its SET-Insertion domain. This ubiquitination is directly catalyzed by UBE2E family of E2 enzymes in an E3-independent manner while the conjugated-ubiquitin (Ub) is protected from active deubiquitination.

  2. These results suggest that the ubiquitination of SETDB1 at lysine 867 controls the expression of its target gene by activating its H3K9 methyltransferase activity.

  3. Authors observed several complementary mechanisms contributing to the upregulation of SETDB1 in HCC (show FAM126A Antibodies) cells. Besides copy number gains at the SETDB1 gene locus at chromosome 1q21 enhanced SETDB1 transcription mediated by the transcription factor SP1 (show SP1 Antibodies) could be detected.

  4. BRCA1 and SETDB1 stand out as the most significant prognostic markers in this group of patients

  5. These results suggest that SETDB1- mediated FosB (show FOSB Antibodies) expression is a common molecular phenomenon, and might be a novel pathway responsible for the increase in cell proliferation that frequently occurs during anticancer drug therapy.

  6. SETDB1 mutations are associated with malignant pleural mesotheliomas.

  7. Upon HBV infection, cellular mechanisms involving SETDB1-mediated H3K9me3 and HP1 (show DEFA1 Antibodies) induce silencing of HBV cccDNA transcription through modulation of chromatin structure.

  8. The SETDB1 protein was closely associated with the prognosis of prostate cancer (PCa (show FLVCR1 Antibodies)). Bioinformatics suggested that SETDB1 might promote PCa (show FLVCR1 Antibodies) bone metastasis through the WNT (show WNT2 Antibodies) pathway. In conclusion, SETDB1 might be associated with the development of bone metastases from PCa (show FLVCR1 Antibodies)

  9. results indicate that ATF7IP (show ATF7IP Antibodies) does not directly modulate SETDB1 catalytic activity, suggesting alternate roles, such as affecting cellular localization or mediating interaction with additional binding partners.

  10. SETDB1 is an oncogene (show RAB1A Antibodies) that is frequently up-regulated in human HCCs (show HCCS Antibodies); the multiplicity of SETDB1 activating mechanisms at the chromosomal, transcriptional, and posttranscriptional levels together facilitates SETDB1 up-regulation in human HCC (show FAM126A Antibodies)

Mouse (Murine) SET Domain, Bifurcated 1 (SETDB1) interaction partners

  1. the SETDB1 repressor complex shields neuronal genomes from excess CTCF (show CTCF Antibodies) genome organizer binding and is critically required for structural maintenance of the protocadherin locus topologically associated domain

  2. The results identify Setdb1 as a newly discovered meiotic and embryonic competence factor safeguarding genome integrity at the onset of life.

  3. SETDB1, a major histone H3K9 methyltransferase is monoubiquitinated at the evolutionarily conserved lysine-867 in its SET-Insertion domain. This ubiquitination is directly catalyzed by UBE2E family of E2 enzymes in an E3-independent manner while the conjugated-ubiquitin (Ub) is protected from active deubiquitination.

  4. study identifed ESET as first trimethylated H3K9 histone methyltransferase playing a crucial role in T cell development

  5. Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genes.

  6. SETDB1 maintains silencing of intracisternal A particle, but in the absence of DNMT1 (show DNMT1 Antibodies), prolonged binding of NP95 (show UHRF1 Antibodies) to hemimethylated DNA transiently disrupts SETDB1-dependent H3K9me3 deposition.

  7. Deletion of Setdb1 led to enlarged Meckel's cartilage. Chondrocytes from the Meckel's cartilage of Setdb1 mutant showed increased in size.

  8. Setdb1 is a maternal-effect (show NLRP5 Antibodies) gene that controls meiotic progression and is essential for early embryogenesis. Setdb1 is an important regulator of Cdc14b (show CDC14B Antibodies).

  9. The currently identified reciprocal action between SETDB1 and PRC2 reveals a novel mechanism underlying ES cell pluripotency and differentiation regulation.

  10. regulates cancer cell growth via methylation of p53 (show TP53 Antibodies)

SETDB1 Antigen Profile

Protein Summary

This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.

Gene names and symbols associated with SETDB1

  • SET domain, bifurcated 1 (Setdb1) antibody
  • SET domain, bifurcated 1 (SETDB1) antibody
  • SET domain, bifurcated 1a (setdb1a) antibody
  • SET domain, bifurcated 1 (setdb1) antibody
  • AU022152 antibody
  • ESET antibody
  • fc07d03 antibody
  • H3-K9-HMTase4 antibody
  • KG1T antibody
  • KMT1E antibody
  • mKIAA0067 antibody
  • NV10069 antibody
  • SETDB1 antibody
  • si:ch211-81a5.6 antibody
  • TDRD21 antibody
  • wu:fc07d03 antibody

Protein level used designations for SETDB1

histone-lysine N-methyltransferase SETDB1 , SET domain, bifurcated 1 , histone-lysine N-methyltransferase SETDB1-like , histone-lysine N-methyltransferase SETDB1-A , ERG-associated protein with SET domain , ERG-associated protein with a SET domain, ESET , H3-K9-HMTase 4 , histone H3-K9 methyltransferase 4 , histone-lysine N-methyltransferase, H3lysine-9 specific 4 , lysine N-methyltransferase 1E , tudor domain containing 21 , SET domain ERG-associated histone methyltransferase

GENE ID SPECIES
689883 Rattus norvegicus
395847 Gallus gallus
469481 Pan troglodytes
716141 Macaca mulatta
100120014 Nasonia vitripennis
100138100 Bos taurus
100157920 Sus scrofa
100411734 Callithrix jacchus
100461671 Pongo abelii
100482250 Ailuropoda melanoleuca
553292 Danio rerio
9869 Homo sapiens
84505 Mus musculus
432147 Xenopus laevis
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