SET Domain Containing (Lysine Methyltransferase) 8 (SETD8) ELISA Kits

Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Additionally we are shipping SETD8 Antibodies (126) and SETD8 Proteins (9) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human SETD8 SETD8 387893 Q9NQR1
Anti-Mouse SETD8 SETD8 67956 Q2YDW7
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More ELISA Kits for SETD8 Interaction Partners

Human SET Domain Containing (Lysine Methyltransferase) 8 (SETD8) interaction partners

  1. miR (show MLXIP ELISA Kits)-502/SET8 regulatory circuit emerges as a key regulator of the pathobiology of breast cancer and a focal point for possible therapeutic intervention.

  2. In non-small cell lung cancer cells, SETD8 expression suppression is involved in tumorigenesis and metastasis.

  3. SET8 and ZEB1 (show ZEB1 ELISA Kits) are functionally interdependent in promoting the epithelial-mesenchymal transition and enhancing the invasive potential of prostate cancer cells in vitro.

  4. SET8 expression is associated with overall survival in gastric cancer

  5. analysis of a structural model for how Set8 uses multivalent interactions to bind and methylate the nucleosome based on crystallographic and solution studies of the Set8/nucleosome complex

  6. This study showed SCF (show KITLG ELISA Kits)(beta-TRCP (show BTRC ELISA Kits)) earmarks Set8 for ubiquitination and degradation in a casein kinase I (show CSNK1D ELISA Kits)-dependent manner, which is activated by DNA-damaging agents.

  7. Overall, the results revealed that miR (show MLXIP ELISA Kits)-127-3p acts as a tumor suppressor and that its down-regulation in cancer may contribute to OS progression and metastasis.

  8. commonality of SPS8I1-3 against SETD8, together with their distinct structures and mechanisms for SETD8 inhibition, argues for the collective application of these compounds as SETD8 inhibitors

  9. SET8 is required for 53BP1 (show TP53BP1 ELISA Kits) recruitment and efficient repair of DSB.

  10. These data suggest that there are significant associations between the miR (show MLXIP ELISA Kits)-502-binding site single nucleotide polymorphism in the 3'-UTR (show UTS2R ELISA Kits) of SET8 and the TP53 (show TP53 ELISA Kits) codon 72 polymorphism with cervical cancer in Chinese, and there is a gene-gene interaction.

Mouse (Murine) SET Domain Containing (Lysine Methyltransferase) 8 (SETD8) interaction partners

  1. PR-Set7 is a direct target of Cul4A (show CUL4A ELISA Kits) for degradation and involved in the formation of lung tumors in the conditional Cul4A (show CUL4A ELISA Kits) transgenic mouse model.

  2. These results suggest that Setd8 is an important regulator of erythroid maturation that works in part through repression of Gata2 (show GATA2 ELISA Kits) expression.

  3. These results establish SetD8 as a determinant of erythroid cell maturation and provide a framework for understanding how a broadly expressed histone-modifying enzyme mediates cell-type-specific GATA factor function.

  4. all of the H3K36-specific methyltransferases, including ASH1L (show ASH1L ELISA Kits), HYPB, NSD1 (show NSD1 ELISA Kits), and NSD2 (show WHSC1 ELISA Kits) were inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a (show EHMT2 ELISA Kits), and Pr-Set7 were not affected by ubH2A.

  5. Data indicate a vital link between GATA-1 (show GATA1 ELISA Kits) and the histone H4 lysine 20 methyltransferase PR-Set7/SetD8 (SetD8).

  6. Pr-set7 knockdown caused increased gammaH2AX (show H2AFX ELISA Kits) foci on chromosomes indicating DNA damage on chromosomes.

  7. Setd8 is a crucial inhibitor of apoptosis in skin and its activity is essential for epidermal stem cell survival, proliferation and differentiation

  8. the SET8 and PCNA (show PCNA ELISA Kits) interaction couples H4-K20 (show KRT20 ELISA Kits) methylation with DNA replication

  9. PR-Set7 enzymatic activity is essential for mammalian cell cycle progression and for the maintenance of genomic stability, most likely by monomethylating histone H4K20.

  10. Cell cycle analysis after synchronization indicated that defects at the S and G(2)/M phases were a consequence of decreased H4K20me1 due to the absence of PR-Set7.

SETD8 Antigen Profile

Antigen Summary

Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes (By similarity).

Gene names and symbols associated with SETD8

  • SET domain containing (lysine methyltransferase) 8 (SETD8) antibody
  • SET domain containing (lysine methyltransferase) 8 (Setd8) antibody
  • 2410195B05Rik antibody
  • AA617402 antibody
  • AW536475 antibody
  • KMT5A antibody
  • PR-SET7 antibody
  • SET07 antibody
  • SET8 antibody

Protein level used designations for SETD8

H4-K20-HMTase SETD8 , H4-K20-specific histone methyltransferase , H4K20-specific histone methyltransferase splice variant Set8b , N-lysine methyltransferase SETD8 , PR/SET domain containing protein 8 , PR/SET domain-containing protein 07 , PR/SET07 , SET domain-containing protein 8 , histone-lysine N-methyltransferase SETD8 , lysine N-methyltransferase 5A , PR-Set7 , SET domain-containing 8

387893 Homo sapiens
67956 Mus musculus
532622 Bos taurus
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