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Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Additionally we are shipping SETD8 Antibodies (123) and many more products for this protein.
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Human SETD8 Protein expressed in Escherichia coli (E. coli) - ABIN2004726
Nishioka, Rice, Sarma, Erdjument-Bromage, Werner, Wang, Chuikov, Valenzuela, Tempst, Steward, Lis, Allis, Reinberg: PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. in Molecular cell 2002
Show all 4 references for ABIN2004726
miR (show MLXIP Proteins)-502/SET8 regulatory circuit emerges as a key regulator of the pathobiology of breast cancer and a focal point for possible therapeutic intervention.
In non-small cell lung cancer cells, SETD8 expression suppression is involved in tumorigenesis and metastasis.
SET8 and ZEB1 are functionally interdependent in promoting the epithelial-mesenchymal transition and enhancing the invasive potential of prostate cancer cells in vitro.
SET8 expression is associated with overall survival in gastric cancer
analysis of a structural model for how Set8 uses multivalent interactions to bind and methylate the nucleosome based on crystallographic and solution studies of the Set8/nucleosome complex
This study showed SCF (show KITLG Proteins)(beta-TRCP (show BTRC Proteins)) earmarks Set8 for ubiquitination and degradation in a casein kinase I (show CSNK1D Proteins)-dependent manner, which is activated by DNA-damaging agents.
Overall, the results revealed that miR (show MLXIP Proteins)-127-3p acts as a tumor suppressor and that its down-regulation in cancer may contribute to OS progression and metastasis.
commonality of SPS8I1-3 against SETD8, together with their distinct structures and mechanisms for SETD8 inhibition, argues for the collective application of these compounds as SETD8 inhibitors
SET8 is required for 53BP1 (show TP53BP1 Proteins) recruitment and efficient repair of DSB.
These data suggest that there are significant associations between the miR (show MLXIP Proteins)-502-binding site single nucleotide polymorphism in the 3'-UTR of SET8 and the TP53 (show TP53 Proteins) codon 72 polymorphism with cervical cancer in Chinese, and there is a gene-gene interaction.
PR-Set7 is a direct target of Cul4A (show CUL4A Proteins) for degradation and involved in the formation of lung tumors in the conditional Cul4A (show CUL4A Proteins) transgenic mouse model.
These results suggest that Setd8 is an important regulator of erythroid maturation that works in part through repression of Gata2 (show GATA2 Proteins) expression.
These results establish SetD8 as a determinant of erythroid cell maturation and provide a framework for understanding how a broadly expressed histone-modifying enzyme mediates cell-type-specific GATA factor function.
all of the H3K36-specific methyltransferases, including ASH1L (show ASH1L Proteins), HYPB, NSD1, and NSD2 (show WHSC1 Proteins) were inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a (show EHMT2 Proteins), and Pr-Set7 were not affected by ubH2A.
Data indicate a vital link between GATA-1 (show GATA1 Proteins) and the histone H4 lysine 20 methyltransferase PR-Set7/SetD8 (SetD8).
Pr-set7 knockdown caused increased gammaH2AX (show H2AFX Proteins) foci on chromosomes indicating DNA damage on chromosomes.
Setd8 is a crucial inhibitor of apoptosis in skin and its activity is essential for epidermal stem cell survival, proliferation and differentiation
the SET8 and PCNA (show PCNA Proteins) interaction couples H4-K20 (show KRT20 Proteins) methylation with DNA replication
PR-Set7 enzymatic activity is essential for mammalian cell cycle progression and for the maintenance of genomic stability, most likely by monomethylating histone H4K20.
Cell cycle analysis after synchronization indicated that defects at the S and G(2)/M phases were a consequence of decreased H4K20me1 due to the absence of PR-Set7.
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes (By similarity).
, H4-K20-specific histone methyltransferase
, H4K20-specific histone methyltransferase splice variant Set8b
, N-lysine methyltransferase SETD8
, PR/SET domain containing protein 8
, PR/SET domain-containing protein 07
, SET domain-containing protein 8
, histone-lysine N-methyltransferase SETD8
, lysine N-methyltransferase 5A
, SET domain-containing 8