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SET1A is a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone H3 at Lys4. Additionally we are shipping SETD1A Antibodies (40) and many more products for this protein.
Collectively called the WRAD complex, these proteins are pivotal to the HMT (show HNMT ELISA Kits) activity of the SET1 complexes. Recent reports highlight the novel non-canonical functions of WRAD in cellular processes other than its well-studied role in histone methylation and gene expression.
Given the critical tumor suppressor role of p53 (show TP53 ELISA Kits), SETD1A-mediated suppression of this pathway (even in the absence of p53 (show TP53 ELISA Kits) mutations), would be predicted to have profound consequences on tumorigenesis.
Findings provide evidence that SET1A cooperates with CUDR to play a positive potential role during hepatocarcinogenesis and hepatocyte-like stem cells' malignant transformation epigenetically.
Loss-of-function variants in SETD1A cause a range of neurodevelopmental disorders in a Finnish population.
Set1 role in cellular reprogramming and its interactions with Dpy30,Myc,Sox2 and Ash2l reprogramming factors
This study demonstrated that SETD1A mutation showing the highest statistical significance in Autism and Schizophrenia.
suppresses BTG2 (show BTG2 ELISA Kits) expression through its induction of several BTG2 (show BTG2 ELISA Kits)-targeting miRNAs
Set1/MLL complex is indispensable for the transcriptional ability of HSF2.
Study reveals that SETD1A controls tumor metastasis by activating matrix metalloproteinases (MMP) expression and provides an epigenetic link among SETD1A, MMPs, and metastasis of breast cancer.
results demonstrate a novel function of BAF (show BANF1 ELISA Kits) as an epigenetic regulator of HSV lytic infection; hypothesize that BAF (show BANF1 ELISA Kits) facilitates Herpes Simplex Virus IE and E gene expression by recruiting the SETD1A methyltransferase to viral IE and E gene promoters
our study provides valuable information on the molecular interactions between OSKM(Oct4 (show POU5F1 ELISA Kits), Sox2 (show SOX2 ELISA Kits), Klf4 (show KLF4 ELISA Kits), and Myc (show MYC ELISA Kits)) and cofactors and molecular mechanisms for the functional importance of Set1a in ESCs (show NR2E3 ELISA Kits) and early development
revealed a critical role of Setd1a and its mediated epigenetic modifications in regulating the IgH rearrangement and B-cell development
The H3K4 methyltransferase Setd1a is first required at the epiblast stage, whereas Setd1b (show SETD1B ELISA Kits) becomes essential after gastrulation.
embryonic stem cells lacking Cfp1 (CXXC1 (show CXXC1 ELISA Kits)(-/-)) are viable but show increased levels of global histone H3K4 methylation, suggesting that Cfp1 (show CXXC1 ELISA Kits) functions to inhibit or restrict the activity of the Setd1A histone H3K4 methyltransferase complex.
mNSC1 lacks protein-coding capacity
SET1A is a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone H3 at Lys4. The complex is the analog of the S. cerevisiae Set1/COMPASS complex (Lee and Skalnik, 2005
SET domain containing 1A
, histone-lysine N-methyltransferase SETD1A
, histone-lysine N-methyltransferase SETD1-like protein
, histone-lysine N-methyltransferase SETD1A-like
, SET domain-containing protein 1A
, lysine N-methyltransferase 2F
, set1/Ash2 histone methyltransferase complex subunit SET1
, non-selective cation channel 1