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SET1B is a component of a histone methyltransferase complex that produces trimethylated histone H3 at Lys4 (Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Mar 2008].. Additionally we are shipping SETD1B Antibodies (34) and many more products for this protein.
We analyzed SETD1B expression in gastric and colorectal cancer. Loss of SETD1B was identified in 15% to 55% of the GC and CRC (show CALR ELISA Kits) with respect to the microsatellite instability status. Loss of expression was more common in those with SETD1B mutations.
both Rbm15 and the leukemogenic Rbm15-Mkl1 (show MKL1 ELISA Kits) fusion protein interact with the Setd1b histone H3 (show HIST3H3 ELISA Kits)-Lys4 methyltransferase
The H3K4 methyltransferase Setd1a (show SETD1A ELISA Kits) is first required at the epiblast stage, whereas Setd1b becomes essential after gastrulation.
SET1B is a component of a histone methyltransferase complex that produces trimethylated histone H3 at Lys4 (Lee et al., 2007
SET domain-containing protein 1B
, histone-lysine N-methyltransferase SETD1B
, lysine N-methyltransferase 2G