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SET1B is a component of a histone methyltransferase complex that produces trimethylated histone H3 at Lys4 (Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Mar 2008].. Additionally we are shipping SETD1B Antibodies (28) and many more products for this protein.
we propose histone demethylase (show MBD2 ELISA Kits) KDM2B (show KDM2B ELISA Kits) and histone methyltransferase SETD1B as the two most plausible candidate genes involved in intellectual disability, autism, epilepsy, and craniofacial anomalies
We analyzed SETD1B expression in gastric and colorectal cancer. Loss of SETD1B was identified in 15% to 55% of the GC and CRC (show CALR ELISA Kits) with respect to the microsatellite instability status. Loss of expression was more common in those with SETD1B mutations.
both Rbm15 and the leukemogenic Rbm15-Mkl1 (show MKL1 ELISA Kits) fusion protein interact with the Setd1b histone H3 (show HIST3H3 ELISA Kits)-Lys4 methyltransferase
Expression profiling of Setd1b(Gdf9) cKO MII oocytes revealed (1) that Setd1b promotes the expression of the major oocyte transcription factors including Obox1, 2, 5, 7, Meis2 and Sall4; and (2) twice as many mRNAs were upregulated than downregulated, suggesting that Setd1b also promotes the expression of negative regulators of oocyte development with multiple Zfp-KRAB factors implicated.
The H3K4 methyltransferase Setd1a (show SETD1A ELISA Kits) is first required at the epiblast stage, whereas Setd1b becomes essential after gastrulation.
SET1B is a component of a histone methyltransferase complex that produces trimethylated histone H3 at Lys4 (Lee et al., 2007
SET domain-containing protein 1B
, histone-lysine N-methyltransferase SETD1B
, lysine N-methyltransferase 2G