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Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3.
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Human Polyclonal SETD8P1 Primary Antibody for WB - ABIN387998
Chuikov, Kurash, Wilson, Xiao, Justin, Ivanov, McKinney, Tempst, Prives, Gamblin, Barlev, Reinberg: Regulation of p53 activity through lysine methylation. in Nature 2004
Show all 5 references for ABIN387998
study identified a novel locus associated with serum lycopene concentrations and results raise a number of possibilities regarding the nature of the relationship between SETD7 (show SETD7 Antibodies) and lycopene, both independently associated with prostate cancer.
Lysine methylation by SETD7 (show SETD7 Antibodies) is important for the fine-tuning of reactive oxygen species signaling through its regulation on pro-inflammatory responses.
Knock-down of SETD7 (show SETD7 Antibodies) causes differentiation defects in human embryonic stem cell including delay in both the silencing of pluripotency-related genes and the induction of differentiation genes.
Unleashed expression of Mdm2 (show MDM2 Antibodies) in cancer patients with diminished expression of Set7/9 is associated with poor survival outcome.
Based on our results miR (show MLXIP Antibodies)-153 inhibits proliferation and suppresses EMT (show ITK Antibodies) and the invasive potential of ovarian cancer cells through downregulation of SET7 (show SETD7 Antibodies) and ZEB2 (show ZEB2 Antibodies), supporting the pursuit of miR (show MLXIP Antibodies)-153 as a potential target for ovarian cancer intervention.
Findings indicate the regulation of Wnt/beta-catenin signaling and the role of SET domain-containing protein 7/9 (SET7/9) in cancer cells.
Set7 (show SETD7 Antibodies)-induced epigenetic changes contribute to vascular dysfunction in patients with T2DM.
SET9 enriches at hypoxia response elements sites of HIF-1 (show HIF1A Antibodies) responsive glycolytic genes and stabilizes HIF-1alpha (show HIF1A Antibodies) at these sites in hypoxia.
Set7/9 is a potential biomarker in tumour cells and is associated with overexpressed E2F1 (show E2F1 Antibodies) activity.
Results show that histone-lysine N-methyltransferase Set7 (show SETD7 Antibodies) facilitates hepatitis C virus (HCV) replication through the attenuation of interferon-alpha (IFN-alpha (show IFNA Antibodies)) signaling pathways and IFN-related effectors.
SETD7 (show SETD7 Antibodies) is required for Wnt (show WNT2 Antibodies)-driven intestinal tumorigenesis and regeneration. SETD7 (show SETD7 Antibodies)-dependent methylation of YAP (show YAP1 Antibodies) facilitates Wnt (show WNT2 Antibodies)-induced nuclear accumulation of beta-catenin (show CTNNB1 Antibodies).
SET7/9 regulates Nos2 expression through methylation of H3K4 in beta cells.
Data indicate that the ability of transcription factor Pdx1 (show PDX1 Antibodies) to regulate genes in beta cells is partially dependent upon its methylation by methyltransferase Set7/9.
study found that Set7 (show SETD7 Antibodies) is a modifier of the Hippo pathway. Mice that lack Set7 (show SETD7 Antibodies) have a larger progenitor compartment in the intestine, coinciding with increased expression of Yes-associated protein target genes.
The response to hyperglycemia in vascular endothelial cells involves Set7 (show SETD7 Antibodies) mediated changes in chromatin remodeling and gene expression.
Set7/9-mediated methylation of p53 (show TP53 Antibodies) does not represent a major regulatory event and does not appreciably control p53 (show TP53 Antibodies) activity in vivo.
Set7/9 is dispensable for p53 (show TP53 Antibodies) function in the mouse.
Define a biological function for Set7 (show SETD7 Antibodies) in muscle differentiation and provide a molecular mechanism by which Set7 (show SETD7 Antibodies) modulates myogenic transcription factors during muscle differentiation.
Pdx1 (show PDX1 Antibodies)-dependent Set7/9 expression may be crucial to enhancing chromatin accessibility and transcription of beta-cell genes.
Methylation of p53 (show TP53 Antibodies) by Set7 (show SETD7 Antibodies) mediates p53 (show TP53 Antibodies) acetylation and activity in vivo.
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the -K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
, SET domain-containing protein 7
, histone H3-K4 methyltransferase SETD7
, histone H3-lysine 4-specific methyltransferase
, histone-lysine N-methyltransferase SETD7
, lysine N-methyltransferase 7
, H3-K4 methyltransferase