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SH2 Domain Containing 1B (SH2D1B) ELISA Kits

By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001 [PubMed 11689425]).[supplied by OMIM, Mar 2008].. Additionally we are shipping SH2D1B Antibodies (57) and SH2D1B Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Rat SH2D1B SH2D1B 501869  
Anti-Human SH2D1B SH2D1B 117157 O14796
Anti-Mouse SH2D1B SH2D1B 26904  
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More ELISA Kits for SH2D1B Interaction Partners

Human SH2 Domain Containing 1B (SH2D1B) interaction partners

  1. Data indicate that Ewing's sarcoma-associated transcript-2 (EAT-2) over-expression increased the anti-tumor activity of NK cells against K562 tumor cell. targets.

  2. EAT-2 mediates its effects in natural killer cells by linking SLAM (show SLAMF1 ELISA Kits) family receptors to phospholipase Cgamma, calcium fluxes, and Erk (show EPHB2 ELISA Kits) kinase.

  3. NTB-A-mediated IFN-gamma production was greatly reduced in the absence of SLAM-associated protein (SAP), demonstrating that cytokine production and cytotoxicity are differentially dependent on SAP and possibly EAT-2

Mouse (Murine) SH2 Domain Containing 1B (SH2D1B) interaction partners

  1. EAT-2 negatively regulates cytokine production in dendritic cells downstream of SLAM (show SLAMF1 ELISA Kits) engagement and a genetic polymorphism that disturbs this process promotes the development of lupus.

  2. EAT-2 mediates its effects in natural killer cells by linking SLAM (show SLAMF1 ELISA Kits) family receptors to phospholipase Cgamma, calcium fluxes, and Erk (show EPHB2 ELISA Kits) kinase.

  3. EAT-2A and EAT-2B act as positive regulators of signaling lymphocyte activation molecule (show SLAMF1 ELISA Kits) family receptor-specific NK cell functions in C57BL/6 mice.

  4. Taken together, the data suggest that both EAT-2A and EAT-2B are adapters that recruit Src (show SRC ELISA Kits) kinases to SLAM (show SLAMF1 ELISA Kits) family receptors using a mechanism that is distinct from that of SAP (show APCS ELISA Kits).

  5. EAT-2 mediates CRACC (show SLAMF7 ELISA Kits) function. In the absence of EAT-2, CRACC (show SLAMF7 ELISA Kits) inhibited natural killer cell function.

SH2D1B Antigen Profile

Antigen Summary

By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001

Gene names and symbols associated with SH2D1B

  • SH2 domain containing 1B (Sh2d1b) antibody
  • SH2 domain containing 1B (SH2D1B) antibody
  • SH2 domain protein 1B1 (Sh2d1b1) antibody
  • EAT-2 antibody
  • EAT-2A antibody
  • Eat2 antibody
  • Eat2a antibody
  • RGD1563935 antibody
  • Sh2d1b antibody
  • Sh2d1b1 antibody

Protein level used designations for SH2D1B

SH2 domain protein 1B1 , SH2 domain containing 1B , SH2 domain-containing protein 1B , EAT-2 , EWS/FLI1-activated transcript 2 , SH2 domain-containing molecule EAT2 , EWS/FLI1 activated transcript 2

GENE ID SPECIES
501869 Rattus norvegicus
418411 Gallus gallus
457464 Pan troglodytes
609474 Canis lupus familiaris
617485 Bos taurus
720097 Macaca mulatta
117157 Homo sapiens
26904 Mus musculus
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