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SH2 Domain Containing 1B Proteins (SH2D1B)

By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001 [PubMed 11689425]).[supplied by OMIM, Mar 2008].. Additionally we are shipping SH2D1B Antibodies (58) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat SH2D1B SH2D1B 501869  
SH2D1B 117157 O14796
SH2D1B 26904  
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Top SH2D1B Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

SH2D1B Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for SH2 Domain Containing 1B (SH2D1B) Interaction Partners

Human SH2 Domain Containing 1B (SH2D1B) interaction partners

  1. Data indicate that Ewing's sarcoma-associated transcript-2 (EAT-2) over-expression increased the anti-tumor activity of NK cells against K562 tumor cell. targets.

  2. EAT-2 mediates its effects in natural killer cells by linking SLAM (show SLAMF1 Proteins) family receptors to phospholipase Cgamma, calcium fluxes, and Erk (show EPHB2 Proteins) kinase.

  3. NTB-A-mediated IFN-gamma production was greatly reduced in the absence of SLAM-associated protein (SAP), demonstrating that cytokine production and cytotoxicity are differentially dependent on SAP and possibly EAT-2

Mouse (Murine) SH2 Domain Containing 1B (SH2D1B) interaction partners

  1. EAT-2 negatively regulates cytokine production in dendritic cells downstream of SLAM (show SLAMF1 Proteins) engagement and a genetic polymorphism that disturbs this process promotes the development of lupus.

  2. EAT-2 mediates its effects in natural killer cells by linking SLAM (show SLAMF1 Proteins) family receptors to phospholipase Cgamma, calcium fluxes, and Erk (show EPHB2 Proteins) kinase.

  3. EAT-2A and EAT-2B act as positive regulators of signaling lymphocyte activation molecule (show SLAMF1 Proteins) family receptor-specific NK cell functions in C57BL/6 mice.

  4. Taken together, the data suggest that both EAT-2A and EAT-2B are adapters that recruit Src (show SRC Proteins) kinases to SLAM (show SLAMF1 Proteins) family receptors using a mechanism that is distinct from that of SAP (show APCS Proteins).

  5. EAT-2 mediates CRACC (show SLAMF7 Proteins) function. In the absence of EAT-2, CRACC (show SLAMF7 Proteins) inhibited natural killer cell function.

SH2D1B Protein Profile

Protein Summary

By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001

Gene names and symbols associated with SH2D1B

  • SH2 domain containing 1B (Sh2d1b)
  • SH2 domain containing 1B (SH2D1B)
  • SH2 domain protein 1B1 (Sh2d1b1)
  • EAT-2 protein
  • EAT-2A protein
  • Eat2 protein
  • Eat2a protein
  • RGD1563935 protein
  • Sh2d1b protein
  • Sh2d1b1 protein

Protein level used designations for SH2D1B

SH2 domain protein 1B1 , SH2 domain containing 1B , SH2 domain-containing protein 1B , EAT-2 , EWS/FLI1-activated transcript 2 , SH2 domain-containing molecule EAT2 , EWS/FLI1 activated transcript 2

GENE ID SPECIES
501869 Rattus norvegicus
418411 Gallus gallus
457464 Pan troglodytes
609474 Canis lupus familiaris
617485 Bos taurus
720097 Macaca mulatta
117157 Homo sapiens
26904 Mus musculus
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