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By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001 [PubMed 11689425]).[supplied by OMIM, Mar 2008].. Additionally we are shipping SH2D1B Antibodies (58) and many more products for this protein.
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Data indicate that Ewing's sarcoma-associated transcript-2 (EAT-2) over-expression increased the anti-tumor activity of NK cells against K562 tumor cell. targets.
EAT-2 mediates its effects in natural killer cells by linking SLAM (show SLAMF1 Proteins) family receptors to phospholipase Cgamma, calcium fluxes, and Erk (show EPHB2 Proteins) kinase.
NTB-A-mediated IFN-gamma production was greatly reduced in the absence of SLAM-associated protein (SAP), demonstrating that cytokine production and cytotoxicity are differentially dependent on SAP and possibly EAT-2
EAT-2 negatively regulates cytokine production in dendritic cells downstream of SLAM (show SLAMF1 Proteins) engagement and a genetic polymorphism that disturbs this process promotes the development of lupus.
EAT-2A and EAT-2B act as positive regulators of signaling lymphocyte activation molecule (show SLAMF1 Proteins) family receptor-specific NK cell functions in C57BL/6 mice.
Taken together, the data suggest that both EAT-2A and EAT-2B are adapters that recruit Src (show SRC Proteins) kinases to SLAM (show SLAMF1 Proteins) family receptors using a mechanism that is distinct from that of SAP (show APCS Proteins).
EAT-2 mediates CRACC (show SLAMF7 Proteins) function. In the absence of EAT-2, CRACC (show SLAMF7 Proteins) inhibited natural killer cell function.
By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001
SH2 domain protein 1B1
, SH2 domain containing 1B
, SH2 domain-containing protein 1B
, EWS/FLI1-activated transcript 2
, SH2 domain-containing molecule EAT2
, EWS/FLI1 activated transcript 2