You are viewing an incomplete version of our website. Please click to reload the website as full version.

anti-SH2 Domain Protein 1A (SH2D1A) Antibodies

a component of amyloid P. Additionally we are shipping SH2 Domain Protein 1A Kits (13) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SH2D1A 29339 P23680
SH2D1A 4068 O60880
SH2D1A 20400 O88890
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-SH2 Domain Protein 1A Antibodies at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Western blot analysis of SAP Antibody (Center E300) (ABIN391594) in Y79,A2058,CEM cell line lysates(35 µg/lane). SAP (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB Western blot analysis using SAP antibody on NK-92 cell lysate at 10 µg/ml). 100 μg Log in to see 4 to 6 Days
$260.70
Details
Human Rabbit Un-conjugated ELISA, WB   200 μL Log in to see 11 to 16 Days
$532.71
Details
Human Rat PE FACS, ICS 100 Tests Log in to see 5 to 6 Days
$387.62
Details
Human Rat EFluor 660 FACS, ICS Intracellular staining of normal human peripheal blood cells with Anti- Human CD8a PE  and Rat IgG2a K Isotype Control eFluor® 660  (left) or Anti-Human SAP eFluor® 660 (right), using the Foxp3/Transcription Factor Staining Buffer Set  and protocol. Cells in the lymphocyte gate were used for analysis. 100 Tests Log in to see 5 to 6 Days
$398.74
Details
Human Rabbit Un-conjugated   100 μL Log in to see 9 to 19 Days
$322.58
Details
Human Rabbit Un-conjugated   50 μL Log in to see 9 to 19 Days
$417.00
Details
Human Rabbit Un-conjugated WB   400 μL Log in to see 6 to 8 Days
$454.30
Details

SH2D1A Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Rat (Rattus)

Human ,
,
,
,
Mouse (Murine)

Top referenced anti-SH2 Domain Protein 1A Antibodies

  1. Human Polyclonal SH2D1A Primary Antibody for WB - ABIN306863 : Tangye, Lazetic, Woollatt, Sutherland, Lanier, Phillips: Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP. in Journal of immunology (Baltimore, Md. : 1950) 1999 (PubMed)
    Show all 4 references for ABIN306863

More Antibodies against SH2 Domain Protein 1A Interaction Partners

Human SH2 Domain Protein 1A (SH2D1A) interaction partners

  1. In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.

  2. The mutation c.131G>A in this patient was found in combination with a second SH2D1A mutation

  3. Study of SAP (show APCS Antibodies) expression is specific but may have insufficient sensitivity for screening XLP1 as a single tool; however, combination with 2B4 (show CD244 Antibodies) functional assay allows identification of all cases

  4. Molecular dynamics analysis revealed that mutant R32Q and T53I structures of SAP (show APCS Antibodies) exhibited structural variation with respect to their backbone atoms before and after binding with the unphosphorylated SLAM (show SLAMF1 Antibodies) peptide.

  5. Signaling lymphocytic activation molecule (SLAM)/SLAM (show SLAMF1 Antibodies)-associated protein pathway regulates human B-cell tolerance.

  6. In patients suffering from X-linked lymphoproliferative disease (XLP1), SAP (show APCS Antibodies) is nonfunctional, not only abolishing the activating function of 2B4 (show CD244 Antibodies), but rendering this receptor inhibitory.

  7. our data reveal how SAP (show APCS Antibodies) nucleates a previously unknown signaling complex involving NTB-A (show SLAMF6 Antibodies) and LCK (show LCK Antibodies) to potentiate restimulation-induced cell death of activated human T cells.

  8. SAP (show APCS Antibodies) is a new actor downstream of PECAM-1 (show PECAM1 Antibodies) and its binding regulates PECAM-1 (show PECAM1 Antibodies) mediated cell adhesion.

  9. An intronic single nucleotide polymorphism of the SH2D1A gene is associated with systemic lupus erythematosus.

  10. Result suggests that p53 (show TP53 Antibodies) contributes to T cell homeostasis through the induction of the pro-apoptotic SAP (show APCS Antibodies).

Mouse (Murine) SH2 Domain Protein 1A (SH2D1A) interaction partners

  1. SAP (show APCS Antibodies) is an essential molecule for autoimmune antibody production.

  2. In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.

  3. SLAM (show SLAMF1 Antibodies)-SAP (show APCS Antibodies) signaling promotes differentiation of IL-17 (show IL17A Antibodies)-producing T cells and progression of experimental autoimmune encephalomyelitis.

  4. these data suggest that SAP (show APCS Antibodies) is critical for regulating type II NKT (show CTSL1 Antibodies) cell responses.

  5. functional analysis in vitro indicates that SAP-2 is a non-functional isoform due to decreased protein stability

  6. Here we report that B cell intrinsic responses to haptenated protein antigens are impaired in SAP (show APCS Antibodies)-/- mice and in Rag-/- mice into which B cells derived from SAP (show APCS Antibodies)-/- mice together with wt CD4 (show CD4 Antibodies)+ T cells had been transferred.

  7. SAP (show APCS Antibodies) plays an essential role in CIA (show NCOA5 Antibodies) because of Fyn (show FYN Antibodies)-independent and Fyn (show FYN Antibodies)-dependent effects on TFH cells and, possibly, other T cell types.

  8. SAP (show APCS Antibodies) was required not only for the initiation but also for the progression of primary T cell-driven B cell responses to haptens.

  9. Loss of SAP (show APCS Antibodies) expression is associated with invariant NKT (show CTSL1 Antibodies) cell cytotoxicity and defective lytic synapse formation.

  10. SAP (show APCS Antibodies) is required for the development of innate phenotype in H2-M3--restricted Cd8 (show CD8A Antibodies)(+) T cells.

SH2 Domain Protein 1A (SH2D1A) Antigen Profile

Protein Summary

This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SH2D1A

  • amyloid P component, serum (Apcs) antibody
  • SH2 domain containing 1A (SH2D1A) antibody
  • SH2 domain containing 1A (Sh2d1a) antibody
  • SH2 domain protein 1A (Sh2d1a) antibody
  • DSHP antibody
  • EBVS antibody
  • Gm686 antibody
  • IMD5 antibody
  • LYP antibody
  • MTCP1 antibody
  • RGD1562408 antibody
  • SAP antibody
  • SAP/SH2D1A antibody
  • XLP antibody
  • XLPD antibody

Protein level used designations for SH2D1A

serum amyloid P-component , Duncan disease SH2-protein , SH2 domain-containing protein 1A , SLAM associated protein/SH2 domain protein 1A , SLAM-associated protein , T cell signal transduction molecule SAP , T-cell signal transduction molecule SAP , signaling lymphocyte activation molecule-associated protein , signaling lymphocytic activation molecule-associated protein , SH2 domain protein 1A , Duncan disease homolog

GENE ID SPECIES
29339 Rattus norvegicus
4068 Homo sapiens
501502 Rattus norvegicus
20400 Mus musculus
Selected quality suppliers for anti-SH2 Domain Protein 1A (SH2D1A) Antibodies
Did you look for something else?