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The protein encoded by SH2B2 is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. Additionally we are shipping SH2B2 Antibodies (9) and many more products for this protein.
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Association between variations in the SH2B2 gene and growth traits in Chinese cattle.
Deletion of liver SH2B1 (show SH2B1 Proteins) in SH2B2 null mice attenuated very low-density lipoprotein (VLDL) secretion.
APS facilitates c-Cbl (show CBL Proteins) tyrosine phosphorylation and GLUT4 (show SLC2A4 Proteins) translocation in response to insulin (show INS Proteins) in 3T3-L1 adipocytes
Data show that the adapter protein APS preferentially associates with phosphorylated Tyr-568 and Tyr-936 of the receptor for stem-cell factor (c-Kit).
Lnk (show SH2B3 Proteins), SH2-B (show SH2B1 Proteins), and APS have roles in mast cell development, growth, and functions
APS might have a novel regulatory role in actin reorganization and control of B-1 cell compartment size.
Knockdown of the mouse APS gene abolished the insulin (show INS Proteins)-stimulated phosphorylation of c-Cbl (show CBL Proteins).
APS appears to play novel negative regulatory roles in BCR signaling, actin reorganization pathways, and control of compartment sizes of B-lineage cells
These results identify Enigma as a novel APS-binding protein and suggest that the APS/Enigma complex plays a critical role in actin cytoskeleton organisation.
SH2-B (show SH2B1 Proteins), but not APS, is a key positive regulator of energy and glucose metabolism in mice
APS enhanced ligand-dependent multi-ubiquitination of the insulin receptor (IR (show INSR Proteins)) in CHO cells.
Studies indicate that insulin receptor (IR (show INSR Proteins)) and IGF Type 1 Receptor (IGFR) have been identified as important partners of Grb10 (show GRB10 Proteins)/14 and SH2B1 (show SH2B1 Proteins)/B2 adaptors.
We present here a novel stimulatory mechanism of Vav3 (show VAV3 Proteins) in which APS directly relieves the autoinhibitory CH domain and furthermore enhances its tyrosine phosphorylation by Lck (show LCK Proteins).
N-terminal residues distal to the phosphotyrosine directly contact residues of the four-helix bundle of the TKB domain of the adapter protein (show TOLLIP Proteins) APS
The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway.
PRKR-interacting protein 1 homolog
, SH2B adaptor protein 2
, SH2B adapter protein 2-like
, SH2 and PH domain-containing adapter protein APS
, SH2B adapter protein 2
, adapter protein with pleckstrin homology and Src homology 2 domains
, adaptor protein with pleckstrin homology and src homology 2 domains
, insulin receptor substrate 5